Melatonin as a putative protection against myocardial injury in COVID-19 infection

Šimko, Fedor; Hrenak, Jaroslav; Reíter, Russel J.

doi:10.1080/17512433.2020.1814141

Cited by 24 publications

(20 citation statements)

References 23 publications

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“…Finally, last year, under the direction of Professor Reuter, authors published several articles claiming that MEL could effectively treat the new COVID-19 infection [74][75][76][77][78]. Moreover, the authors suggested that MEL may be useful in the fight against COVID-19-induced disorders of various organs e.g., heart [74,76] and lungs. These assumptions certainly need confirmation and expand the possibilities of further use of MEL in medicine and pharmacology.…”

Section: The Role Of Melatonin In Pathologiesmentioning

confidence: 99%

Melatonin as a Potential Multitherapeutic Agent

Baburina

Lomovsky

Krestinina

2021

JPM

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Melatonin (N-acetyl-5-methoxytryptamine, MEL) is a hormone produced by the pineal gland that was discovered many years ago. The physiological roles of this hormone in the body are varied. The beneficial effects of MEL administration may be related to its influence on mitochondrial physiology. Mitochondrial dysfunction is considered an important factor in various physiological and pathological processes, such as the development of neurodegenerative and cardiovascular diseases, diabetes, various forms of liver disease, skeletal muscle disorders, and aging. Mitochondrial dysfunction induces an increase in the permeability of the inner membrane, which leads to the formation of a permeability transition pore (mPTP) in the mitochondria. The long-term administration of MEL has been shown to improve the functional state of mitochondria and inhibit the opening of the mPTP during aging. It is known that MEL is able to suppress the initiation, progression, angiogenesis, and metastasis of cancer as well as the sensitization of malignant cells to conventional chemotherapy and radiation therapy. This review summarizes the studies carried out by our group on the combined effect of MEL with chemotherapeutic agents (retinoic acid, cytarabine, and navitoclax) on the HL-60 cells used as a model of acute promyelocytic leukemia. Data on the effects of MEL on oxidative stress, aging, and heart failure are also reported.

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Section: The Role Of Melatonin In Pathologiesmentioning

confidence: 99%

Melatonin as a Potential Multitherapeutic Agent

Baburina

Lomovsky

Krestinina

2021

JPM

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“…The outbreak of the COVID-19 pandemic has not only afflicted everyday life at manifold levels but also introduced novel therapeutic challenges [5,6]. Unfortunately, a number of clinical trials testing antiviral, anti-inflammatory and immunomodulatory substances have brought more disappointment than delight.…”

Section: Sars-cov-2 Ang II Ang 1-7 Interactionmentioning

confidence: 99%

Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?

Šimko

Baka

2021

Clinical Science

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Angiotensin-converting enzyme 2 (ACE2) is the leading player of the protective renin–angiotensin system (RAS) pathway but also the entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RAS inhibitors seemed to interfere with the ACE2 receptor, and their safety was addressed in COVID-19 patients. Pedrosa et al. (Clin. Sci. (Lond.) (2021), 135, 465–481) showed in rats that captopril and candesartan up-regulated ACE2 expression and the protective RAS pathway in lung tissue. In culture of pneumocytes, the captopril/candesartan-induced ACE2 up-regulation was associated with inhibition of ADAM17 activity, counterbalancing increased ACE2 expression, which was associated with reduced SARS-CoV-2 spike protein entry. If confirmed in humans, these results could become the pathophysiological background for justifying RAS inhibitors as cornerstone cardiovascular protectives even during COVID-19 pandemic.

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“…Treatment of the hormone significantly healed myocardial injuries, by repressing inflammation (31). Other possible mechanisms of melatonin include the regulation of the rate of autophagy and apoptosis inhibition in mice with CVB3-induced myocarditis (15,31,32).…”

Section: Suggested Mechanisms Of Action Of Melatonin Against Viral Infectionsmentioning

confidence: 99%

Pineal hormone melatonin as an adjuvant treatment for COVID‑19 (Review)

et al. 2021

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The beneficial properties of the pineal hormone, melatonin, as a neuroprotective and cardioprotective agent, have been previously identified. Furthermore, melatonin plays essential roles in biological rhythms resynchronization, sleep initiation/maintenance and metabolic, ocular, rheumatological diseases. In addition to these functions, melatonin is known to exert immunomodulation, anti-inflammatory and anti-oxidative effects. Due to these properties, coupled with its non-toxic nature, melatonin has been suggested to limit viral infections; however, melatonin cannot be classified as a viricidal drug. In addition, the recent increase in the number of clinical trials on melatonin's role, as an adjuvant treatment for COVID-19, has resurged the interest of the scientific community in this hormone. The present short review aimed to improve the understanding of the antiviral/anti-COVID-19 profile of melatonin and the clinical trials that have recently been conducted, with respect to its co-administration in treating individuals with COVID-19.

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Melatonin as a putative protection against myocardial injury in COVID-19 infection

Cited by 24 publications

References 23 publications

Melatonin as a Potential Multitherapeutic Agent

Melatonin as a Potential Multitherapeutic Agent

Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?

Pineal hormone melatonin as an adjuvant treatment for COVID‑19 (Review)

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