Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus

Gimeno, M.F.; Landa, Adriana I; Sterín-Speziale, Norma; Cardinali, Daniel P.; Gimeno, A.L.

doi:10.1016/0014-2999(80)90098-9

Cited by 66 publications

(28 citation statements)

References 22 publications

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Section: Melatonin and Prostaglandin Releasementioning

confidence: 82%

“…Animal data indicate that pineal melatonin is involved in the regulation of PG synthesis and release (Landa et al, 1977;Gimeno et al, 1980). Melatonin, like the PG inhibitor indomethacin, has been reported to depress spontaneous uterine contractility, inhibit oxytocin-induced uterine motility in ovariectomized rats, reduce the release of PG in the medium of incubated uteri, and inhibit PGE, and PGFZalpha production and release in the uterus and medial basal hypothalamus (Hertz-Eshel & Rahamimoff, 1965;Gimeno et al, 1980).…”

Section: Melatonin and Prostaglandin Releasementioning

confidence: 99%

“…1983): (d) melatonin stimulates progesterone secretion (MacPhee et al. 1975); and (e) melatonin inhibits uterine PG synthesis and release (Gimeno et al, 1980) (Table 1).…”

Section: Hippocratesmentioning

confidence: 99%

“…Melatonin, like the PG inhibitor indomethacin, has been reported to depress spontaneous uterine contractility, inhibit oxytocin-induced uterine motility in ovariectomized rats, reduce the release of PG in the medium of incubated uteri, and inhibit PGE, and PGFZalpha production and release in the uterus and medial basal hypothalamus (Hertz-Eshel & Rahamimoff, 1965;Gimeno et al, 1980). The inhibitory effects of melatonin on PG synthesis are reversed by the administration of PGF2a,pha (Gimeno et al, 1980). Based on these findings, it has been suggested that melatonin may be unique among natural monoamine derivatives in causing inhibition of PG synthesis and release in peripheral smooth muscles (Quastel & Rahamimoff, 1965;Rahamimoff et al, 1965) and in the brain (Gimeno et al, 1985).…”

Section: Melatonin and Prostaglandin Releasementioning

confidence: 99%

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Letter to the Editor: Dysmenorrhea and the Pineal Gland

Sandyk

1992

International Journal of Neuroscience

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Section: Melatonin and Prostaglandin Releasementioning

confidence: 82%

Section: Melatonin and Prostaglandin Releasementioning

confidence: 99%

“…1983): (d) melatonin stimulates progesterone secretion (MacPhee et al. 1975); and (e) melatonin inhibits uterine PG synthesis and release (Gimeno et al, 1980) (Table 1).…”

Section: Hippocratesmentioning

confidence: 99%

Section: Melatonin and Prostaglandin Releasementioning

confidence: 99%

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Letter to the Editor: Dysmenorrhea and the Pineal Gland

Sandyk

1992

International Journal of Neuroscience

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“…According to Schlabritz-Loutsevitch et al (22), these differences are likely to relate to differences in the phase relation between nocturnal melatonin secretion and maximal myometrial contractile activity (high at night in primates; high during the day in rodents). Gimeno et al (23), on the other hand, suggested that melatonin can have a suppressive effect on uterine contractility by inhibition of prostaglandin production in vitro. Furthermore, our data show for the first time that melatonin has a unique dual effect on the rat uterus in vivo, including the individual excitation of uterine myoelectrical activity and the suppression of oxytocininduced uterine contractile signals in a dose-dependent manner (Table 1) (Figure 1, 2).…”

Section: Discussionmentioning

confidence: 99%

Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats

Şimşek¹,

Parlakpınar²,

Turhan³

et al. 2014

J Turkish German Gynecol Assoc

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(2) melatonin applied as 0.4 mg/kg/IV (n=8); (3) melatonin applied as 4 mg/kg/IV (n=8); (4) single dose of oxytocin (100 mU/kg) injected IV (n=8); (5) melatonin (0.4 mg/kg) plus oxytocin (100 mU/kg) (n=8); and (6) melatonin (4 mg/kg) plus oxytocin (100 mU/kg) injected IV (n=8). Each rat underwent a laparotomy, and uterine myoelectrical signals were recorded. The mean spectrum, averaged over the spectral content of signals in each group, was compared. Results:Melatonin induced uterine myoelectrical activity in a dose-dependent manner. Treatment of melatonin after oxytocin suppressed the mean power of the signals. Serum melatonin concentrations were significantly higher in melatonin-treated rats. Conclusion:Melatonin itself at two different dose levels was found to be equally effective in stimulating the uterine electrical signals, although oxytocin-induced uterine electrical activity was suppressed by melatonin. These findings merit further investigations on the possible beneficial role of melatonin in the treatment of conditions associated with abnormal uterine activity. (J Turk Ger Gynecol Assoc 2014; 15: 86-91) Key words: Uterine contraction, melatonin, oxytocin, electrical stimulation Received: 15 December, 2013 Accepted: 29 December, 2013 Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats

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Circadian Regulation of Hormonal Timing and the Pathophysiology of Circadian Dysregulation

Moeller

Bever

Finn

et al. 2022

Comprehensive Physiology

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Circadian rhythms are endogenously generated, daily patterns of behavior and physiology that are essential for optimal health and disease prevention. Disruptions to circadian timing are associated with a host of maladies, including metabolic disease and obesity, diabetes, heart disease, cancer, and mental health disturbances. The circadian timing system is hierarchically organized, with a master circadian clock located in the suprachiasmatic nucleus (SCN) of the anterior hypothalamus and subordinate clocks throughout the CNS and periphery. The SCN receives light information via a direct retinal pathway, synchronizing the master clock to environmental time. At the cellular level, circadian rhythms are ubiquitous, with rhythms generated by interlocking, autoregulatory transcription-translation feedback loops. At the level of the SCN, tight cellular coupling maintains rhythms even in the absence of environmental input. The SCN, in turn, communicates timing information via the autonomic nervous system and hormonal signaling. This signaling couples individual cellular oscillators at the tissue level in extra-SCN brain loci and the periphery and synchronizes subordinate clocks to external time. In the modern world, circadian disruption is widespread due to limited exposure to sunlight during the day, exposure to artificial light at night, and widespread use of light-emitting electronic devices, likely contributing to an increase in the prevalence, and the progression, of a host of disease states. The present overview focuses on the circadian control of endocrine secretions, the significance of rhythms within key endocrine axes for typical, homeostatic functioning, and implications for health and disease when dysregulated.

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Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus

Cited by 66 publications

References 22 publications

Letter to the Editor: Dysmenorrhea and the Pineal Gland

Letter to the Editor: Dysmenorrhea and the Pineal Gland

Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats

Circadian Regulation of Hormonal Timing and the Pathophysiology of Circadian Dysregulation

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