Melatonin Effects on Hard Tissues: Bone and Tooth

Liu, Jie; Huang, Fang; He, Hongwen

doi:10.3390/ijms140510063

Cited by 71 publications

(53 citation statements)

References 59 publications

(78 reference statements)

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“…; Liu et al. ). Furthermore, MLT can inhibit bone resorption by suppressing osteoclast activity and can reduce the period of osseointegration (Cengiz & Wang ; Clafshenkel et al.…”

mentioning

confidence: 98%

Zirconia with laser‐modified microgrooved surface vs. titanium implants covered with melatonin stimulates bone formation. Experimental study in tibia rabbits

Calvo-Guirado

Salvatierra

Gargallo‐Albiol

et al. 2014

Clinical Oral Implants Res

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“…; Liu et al. ). Furthermore, MLT can inhibit bone resorption by suppressing osteoclast activity and can reduce the period of osseointegration (Cengiz & Wang ; Clafshenkel et al.…”

mentioning

confidence: 98%

Zirconia with laser‐modified microgrooved surface vs. titanium implants covered with melatonin stimulates bone formation. Experimental study in tibia rabbits

Calvo-Guirado

Salvatierra

Gargallo‐Albiol

et al. 2014

Clinical Oral Implants Res

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“…Much attention has been paid in recent years to salivary melatonin because of its antioxidant, anti‐inflammatory and antimicrobial effects on the oral mucosa (Czesnikiewicz‐Guzik et al, ; Boga et al, ; Cengiz et al, ), as well as its involvement in tooth formation (Kumasaka et al, ; Liu et al, ; Tachibana et al, ) and in homeostasis of periodontal tissues (Carpentieri et al, ). Because of its prominent role in oral cavity wellness, melatonin is being incorporated into periodontal scaffolds (Najeeb et al, ) and added to dental hygiene products, such as toothpaste and mouthwash (Reiter et al, ).…”

mentioning

confidence: 99%

Diabetic Status Influences the Storage of Melatonin in Human Salivary Glands

Isola

Lilliu

Loy

et al. 2017

The Anatomical Record

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Recently we reported on the detailed localization of melatonin (and its receptors) in human salivary glands, revealing that serous cells are able to store and secrete melatonin into saliva. Since we found that type 2 diabetic patients display reduced melatonin content in saliva, our next step was to examine the presence of melatonin in salivary glands removed from type 2 diabetic subjects. The resulting data were compared with those previously obtained by identical procedures in non-diabetics, to establish if the diabetic status may affect melatonin distribution. Bioptic samples of diabetic parotid and submandibular glands were fixed, dehydrated, embedded in Epon Resin and processed to demonstrate melatonin reactivity by the immunogold staining method. The labeling density (expressed as the number of gold particles per μm /granule) and the percentage of melatonin-positive granules were assessed in diabetic samples. These values were compared with those in non-diabetic samples and differences were evaluated. In parotid and submandibular diabetic glands the reactivity for melatonin was specifically associated with secretory granules and small vesicles in serous cells. Melatonin reactivity was higher in parotid than in submandibular glands. Our data were in line with those obtained in our previous study on non-diabetic glands. Diabetic salivary glands showed a higher labeling density and a lower number of melatonin-positive granules compared to non-diabetic glands. Taken together, these data might explain the decreased salivary melatonin content and the associated oral problems observed in diabetics. Anat Rec, 301:711-716, 2018. © 2017 Wiley Periodicals, Inc.

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“…Melatonin and estrogen are known to be associated to the biologic rhythm of the cell [19][20][21] . In this study, since zinc transporter in the zinc-finger is missing in Zip13-KO mice, the incremental lines from the circumpulpal dentin and The lamellated structures observed in light microscope corresponded to those seen in TEM characterized by thin and scarce collagen fibers in various sizes and orientations scattered within the granular matrix.…”

Section: Discussionmentioning

confidence: 99%

Histological Analysis of Dentinogenesis Imperfecta in Slc39a13/Zip13 Knockout Mice

Munemasa

Idaira

Fukada

et al. 2014

J. Hard Tissue Biology.

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This study focused on the abnormality of dentin matrix to clarify the pathogenesis of human dentinogenesis imperfecta (DI). Dentin matrix of mandibular molars from wild type (Zip13+/+) and Slc39a/ Zip13 knockout (KO) mice were examined histologically. Hematoxylin and eosin, as well as silver staining, were used for light microscopy. Samples were also observed under backscattered and transmission electron microscopy. Immunohistochemistry using type I collagen was also carried out. Results showed that Zip13-KO mice exhibited 1) lamellated dentin matrix with accentuated incremental lines under the light microscope, 2) abnormal collagen fibers and round shape collagen molecules in transmission electron microscope, and 3) unusual immunoreaction to collagen type I. The similarity in the histological features of dentin in Zip13-KO mice to human DI indicates that Zip13-KO mice may be used as models for investigating the mechanism of human DI.

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Melatonin Effects on Hard Tissues: Bone and Tooth

Cited by 71 publications

References 59 publications

Zirconia with laser‐modified microgrooved surface vs. titanium implants covered with melatonin stimulates bone formation. Experimental study in tibia rabbits

Zirconia with laser‐modified microgrooved surface vs. titanium implants covered with melatonin stimulates bone formation. Experimental study in tibia rabbits

Diabetic Status Influences the Storage of Melatonin in Human Salivary Glands

Histological Analysis of Dentinogenesis Imperfecta in Slc39a13/Zip13 Knockout Mice

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