Melatonin enhances responsiveness to Dichelobacter nodosus vaccine in sheep and increases peripheral blood CD4 T lymphocytes and IgG-expressing B lymphocytes

Ramos, Asunción; Míguez, María Prado; Morgado, Sara; Sánchez-Correa, Beatriz; Gordillo, Juan; Casado, Javier G.; Tarazona, Raquel; Regodón, S.

doi:10.1016/j.vetimm.2018.11.006

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…Melatonin injection in sheep boosts the antibody titer (140) and serum IG G level. As a result, melatonin is suggested to be used as the adjuvant of vaccine to increase the antibody production (141). In fact, this led to substantially higher antibody production and also sustained it for a longer duration than that without melatonin adjuvant (142).…”

Section: Melatonin On Innate and Adaptive Immunitymentioning

confidence: 99%

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

Tan¹,

Hardeland²

2020

Melatonin Res.

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The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19, and avian flu is often caused by the uncontrolled innate immune response and destructive inflammation. The majority of viral diseases are self-limiting under the help of the activated adaptive immune system. This activity is cell proliferation dependent and thus, it requires several weeks to develop. Patients are vulnerable and mortality usually occurs during this window period. To control the innate immune response and reduce the inflammation during this period will increase the tolerance of patients and lowers the mortality in the deadly virus infection. Melatonin is a molecule that displays respective properties, since it downregulates the overreaction of the innate immune response and overshooting inflammation, but also promotes the adaptive immune activity. Many studies have reported the beneficial effects of melatonin on deadly virus infections in different animal models and its therapeutic efficacy in septic shock patients. Furthermore, melatonin has a great safety margin without serious adverse effects. We suggest the use of melatonin as an adjunctive or even regular therapy for deadly viral diseases, especially if no efficient direct anti-viral treatment is available.

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Section: Melatonin On Innate and Adaptive Immunitymentioning

confidence: 99%

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

Tan¹,

Hardeland²

2020

Melatonin Res.

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“…Likewise, given the rich evidence that this extensive literature compiles and the international prestige of some of the personalities that bona fide endorse this clinical strategy, it is difficult for us to find resounding words and a new convincing voice to persuade public health dealers and professionals about the urgency of undertaking standardized clinical trials. Additionally, melatonin upregulates B-cell proliferation and therefore potentiates refined humoral immune responses [166] and modulates positively the innate and adaptive immunities as a vaccine adjuvant [223]. Noticeably, the immunomodulatory action as adjuvant of melatonin may enhance the effectivity of vaccination in immunocompromised individuals, such as aged people and patients with comorbidities, who are at great risk of lethal COVID-19.…”

Section: Melatonin In Adjuvant Therapy Combination Against Sars-cov-2 Infectionmentioning

confidence: 99%

The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy

et al. 2021

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Viral infections constitute a tectonic convulsion in the normophysiology of the hosts. The current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, like any other invading microbe, enacts a generalized immune response once the virus contacts the body. Melatonin is a systemic dealer that does not overlook any homeostasis disturbance, which consequently brings into play its cooperative triad, antioxidant, anti-inflammatory, and immune-stimulant backbone, to stop the infective cycle of SARS-CoV-2 or any other endogenous or exogenous threat. In COVID-19, the corporal propagation of SARS-CoV-2 involves an exacerbated oxidative activity and therefore the overproduction of great amounts of reactive oxygen and nitrogen species (RONS). The endorsement of melatonin as a possible protective agent against the current pandemic is indirectly supported by its widely demonstrated beneficial role in preclinical and clinical studies of other respiratory diseases. In addition, focusing the therapeutic action on strengthening the host protection responses in critical phases of the infective cycle makes it likely that multi-tasking melatonin will provide multi-protection, maintaining its efficacy against the virus variants that are already emerging and will emerge as long as SARS-CoV-2 continues to circulate among us.

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“…Exogenous MLT may act also as an adjuvant in various vaccines and has been shown to enhance the quality and the strength of the immune responses against a variety of microbial and cancer antigens. MLT administered in sheep as an adjuvant for a vaccine against Dichelobacter nodosus could increase specific IgG+ B cells and CD4+ T cells [28]. In a another study in mice, using MLT together with an anti-cancer DNA vaccine increased the generation of specific CD8+ Tcells [29].…”

Section: Introductionmentioning

confidence: 97%

The Well-Recognized Ability of Melatonin to Potentiate an Equilibrated Immune Response Calls for an Urgent Study about Its Use as an Adjuvant in Anti-SARS-Cov-2 Vaccines

Maestroni

2020

vacres

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Vaccines are a major weapon to control the present COVID-19 pandemic. To achieve this goal, vaccines should confer a robust and long-lasting immunity against SARS-Cov-2. Breakthrough infections and waning immunity are currently observed in patients that recovered from COVID-19 as well as in the vaccinated people. Therefore, a highly effective vaccine is needed to control the present and future outbreaks. Exogenous Nacetyl-5-methoxy-tryptamine or melatonin (MLT) is well known to potentiate an effective and equilibrated immune response in a variety of situation including viral and bacterial infections and vaccines against different microbial and cancer antigens. In regard to anti-SARS-Cov-2 vaccines, beside stimulating specific IgG production as well as specific CD4+ and CD8+ T cells, exogenous MLT might also enhance specific IgA and secretory IgA in the mucosae; hence, preventing the re-infection and/or asymptomatic transmission of the virus. Thus, a study is urgently proposed to evaluate the effects of MLT administration either before or after vaccination against SARS-Cov-2 to evaluate its effect on strength, quality and duration of the immunity. Las but not least, due to its powerful antioxidant and anti-inflammatory properties, MLT administration might minimize the occurrence of adverse events after the vaccination.

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Melatonin enhances responsiveness to Dichelobacter nodosus vaccine in sheep and increases peripheral blood CD4 T lymphocytes and IgG-expressing B lymphocytes

Cited by 12 publications

References 22 publications

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy

The Well-Recognized Ability of Melatonin to Potentiate an Equilibrated Immune Response Calls for an Urgent Study about Its Use as an Adjuvant in Anti-SARS-Cov-2 Vaccines

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