Melatonin increased vitamin C and antioxidant enzyme values in the plasma,heart, liver, and kidney of Adriamycin-treated rats

Karakılçık, Ali Ziya; Bıtıren, Muharrem; Zerin, Mustafa; Çelik, Hakim; Aksoy, Nurten

doi:10.3906/biy-1507-79

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…Vitamin C is a key modulator of platelet (PLT) function but its effect on platelet width is not known. The decrease in mean platelet values of vitamin C study group is in line with a study carried out by [29]. It was stated in the study that vitamin C may affect the values of PLT, MPV, PCT and RDW.…”

Section: Discussionsupporting

confidence: 88%

Antioxidant Effects of Vitamin C on Some Hematological Parameters of Male Wistar Rats Exposed to Lead Acetate

Ojeka,

Ukoro,

Onwoke

2024

IBRR

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The study investigated the effects of vitamin C on platelet parameters, white blood cell count and white blood cells differentials in Wistar rats exposed to lead acetate. A total of twenty-four male Wistar rats weighing between 160g and 200g were utilized. The experimental animals were divided into four groups of six rats each (n=6). Group 1 served as the control group (received normal feed and water), group II received 10mg/kg body weight of lead acetate, group III received 100mg/kg body weight of Vitamin C, and group IV received 10mg/kg body weight of lead acetate followed by 100mg/kg body weight of Vitamin C. Lead and Vitamin C, along with normal feed, were administered for four weeks. Blood samples were collected via jugular puncture and stored in EDTA bottles for analysis to determine the blood profile of the rats. The results showed significant increase in Platelet Count (PLT) in group III and a significant decrease in Mean Platelet Volume (MPV) in group IV (Pb + vitamin C). The Mean Platelet Width (MPW) showed decrease in groups 2, 3, and 4 compared to the control group, although this decrease was not statistically significant. The study also noted an elevated level of white blood cells (WBC) in response to the antioxidant treatment, indicating a potential positive impact on immune function. In conclusion, this study demonstrates the therapeutic effect of Vitamin C against the toxic effects of lead on platelet parameters and white blood cell count and differentials.

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Section: Discussionsupporting

confidence: 88%

Antioxidant Effects of Vitamin C on Some Hematological Parameters of Male Wistar Rats Exposed to Lead Acetate

Ojeka,

Ukoro,

Onwoke

2024

IBRR

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“…Lipid peroxidation was also observed in mice treated with ADR [ 55 ]. Moreover, ADR caused excessive production of ROS and decreased activities of CAT, SOD, GSH-Px, GR, and MPO [ 56 ]. Melatonin had protective effects on hepatotoxicity induced by ADR in rats.…”

Section: Protective Effects Of Melatonin On Liver Injuriesmentioning

confidence: 99%

“…Melatonin had protective effects on hepatotoxicity induced by ADR in rats. The decrease in GSH concentration was significantly prevented and the activities of the enzymes mentioned above were improved by melatonin treatment [ 55 , 56 ]. Additionally, histopathological alterations reflecting hepatic dysfunction were significantly improved by melatonin [ 57 ].…”

Section: Protective Effects Of Melatonin On Liver Injuriesmentioning

confidence: 99%

Effects of Melatonin on Liver Injuries and Diseases

Zhang

Meng

et al. 2017

IJMS

102

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Liver injuries and diseases are serious health problems worldwide. Various factors, such as chemical pollutants, drugs, and alcohol, could induce liver injuries. Liver diseases involve a wide range of liver pathologies, including hepatic steatosis, fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocarcinoma. Despite all the studies performed up to now, therapy choices for liver injuries and diseases are very few. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries and diseases remains a priority. Melatonin is a well-known natural antioxidant, and has many bioactivities. There are numerous studies investigating the effects of melatonin on liver injuries and diseases, and melatonin could regulate various molecular pathways, such as inflammation, proliferation, apoptosis, metastasis, and autophagy in different pathophysiological situations. Melatonin could be used for preventing and treating liver injuries and diseases. Herein, we conduct a review summarizing the potential roles of melatonin in liver injuries and diseases, paying special attention to the mechanisms of action.

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“…The results recorded in the present study are in agreement with the findings of Elbe et al (2015) who reported that melatonin significantly increased SOD activity, GSH concentration and decreased MDA concentration in liver of diabetic rats. Also Karakilik et al (2015) stated that melatonin significantly increased SOD activity, GSH concentration in liver and kidney of Adriamycin treated rats. This antioxidant effect of melatonin may be due to its ability to cross different physiological barriers easily as a result of its lipophilic and hydrophilic criteria (El-Sokkary et al 2006), its free radical scavenging power As well as Its ability to deactivate other oxidant compounds (Park et al 2013).…”

Section: Discussionmentioning

confidence: 95%

Efficacy of Melatonin against Oxidative Stress, DNA Damage and Histopathological Changes Induced by Nicotine in Liver and Kidneys of Male Rats

Ahmed¹,

El-Toukhey²,

El-Rahman³

et al. 2021

Int J Vet Sci

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The present study was carried out to investigate and compare the effect of nicotine alone and in combination with melatonin on some oxidants and antioxidant parameters, histopathological changes and DNA integrity in the liver and kidneys of male rats. For this purpose 75 mature male rats weighing 120-140g were randomly divided into five groups; control group (1% ethanol in saline), nicotine group (rats administrated nicotine at a dose of 0.6mg/kg body weight; BW) and nicotine and melatonin groups (rats administrated the same dose of nicotine plus 1, 5 or 10mg/kg BW melatonin, respectively). Nicotine and ‏ melatonin were injected intraperitoneally daily for 21days. Fasting blood samples were collected from each rat one day after the end of last injection (at 22nd day) and sera were collected for determination of total antioxidant capacity (TAC). Five rats were sacrificed from each group; Liver and kidneys were collected for estimation of oxidative stress parameters (MDA, SOD and GSH), histopathological examination and for estimation of DNA damage. The results revealed that nicotine increased MDA, decreased TAC, SOD and GSH, induced histopathological changes and increased the percentage of DNA damage in the liver and kidneys Melatonin administration with nicotine counteracted the effect of nicotine on previous parameters. The effect of melatonin was dose dependent and the 10mg dose produced the highest protective effect. It is concluded that melatonin can ameliorate the harmful effect of nicotine on the liver and kidneys of male rats.

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Melatonin increased vitamin C and antioxidant enzyme values in the plasma,heart, liver, and kidney of Adriamycin-treated rats

Abstract: IntroductionAdriamycin is an important chemotherapeutic agent used for treatment of some cancer varieties, but it has seriously toxic effects in especially in the heart (

Cited by 7 publications

References 41 publications

Antioxidant Effects of Vitamin C on Some Hematological Parameters of Male Wistar Rats Exposed to Lead Acetate

Antioxidant Effects of Vitamin C on Some Hematological Parameters of Male Wistar Rats Exposed to Lead Acetate

Effects of Melatonin on Liver Injuries and Diseases

Efficacy of Melatonin against Oxidative Stress, DNA Damage and Histopathological Changes Induced by Nicotine in Liver and Kidneys of Male Rats

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