Melatonin induction of filamentous structures in non-neuronal cells that is dependent on expression of the human mt1 melatonin receptor

Witt‐Enderby, Paula A.; MacKenzie, Renee S.; McKeon, Raelene M.; Carroll, Elizabeth A.; Bordt, Shannon L.; Melan, Melissa A.

doi:10.1002/(sici)1097-0169(200005)46:1<28::aid-cm4>3.0.co;2-5

Cited by 70 publications

(51 citation statements)

References 61 publications

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“…VPA has been shown to activate the MAPK-ERK pathway in human neuroblastoma SH-SY5Y cells (Yuan et al, 2001) suggesting that this mechanism could be responsible for the VPA-induced GDNF up-regulation observed in other studies (Castro et al, 2005;Chen et al, 2006b). Melatonin, also known to increase the expression of GDNF (Tang et al, 1998;Armstrong and Niles, 2002;Chen et al, 2003;Lee et al, 2006), is able, via the MT1 receptor, to activate the MAPK-ERK pathway (Witt-Enderby et al, 2000).…”

Section: Role Of Mapkmentioning

confidence: 87%

“…Interestingly, melatonin may induce GDNF expression through modulation of PKA and PKC activities, although PKA and PKC seem to have opposing effects on GDNF expression. In addition, melatonin, via the MT1 receptor, can activate the MAPK-ERK pathway (Witt-Enderby et al, 2000), which has been shown to upregulate the transcription of vascular endothelial growth factor via specificity protein (Sp)1 and activating protein (AP)-2 sites (Milanini et al, 1998). This is relevant as both Sp1 and AP-2 binding sites are present in the GDNF promoter (Woodbury et al, 1998;Baecker et al, 1999) thereby providing another means by which melatonin can induce GDNF up-regulation.…”

Section: Immunophilin Ligandsmentioning

confidence: 99%

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Driving GDNF expression: The green and the red traffic lights

Saavedra

Baltazar

Duarte

2008

Progress in Neurobiology

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Section: Role Of Mapkmentioning

confidence: 87%

Section: Immunophilin Ligandsmentioning

confidence: 99%

Driving GDNF expression: The green and the red traffic lights

Saavedra

Baltazar

Duarte

2008

Progress in Neurobiology

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“…1997). Since melatonin can activate the MAPK–ERK pathway via the MT 1 (Witt‐Enderby et al . 2000), the foregoing finding suggests that this pathway is involved in the physiological regulation of this receptor subtype by melatonin.…”

Section: Discussionmentioning

confidence: 99%

Novel targets for valproic acid: up‐regulation of melatonin receptors and neurotrophic factors in C6 glioma cells

Castro

Gallant

Niles

2005

Journal of Neurochemistry

108

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Valproic acid (VPA) is a potent anti-epileptic and effective mood stabilizer. It is known that VPA enhances central GABAergic activity and activates the mitogen-activated protein kinase-extracellular signal-regulated kinase (MAPK-ERK) pathway. It can also inhibit various isoforms of the enzyme, histone deacetylase (HDAC), which is associated with modulation of gene transcription. Recent in vivo studies indicate a neuroprotective role for VPA, which has been found to up-regulate the expression of brain-derived neurotrophic factor (BDNF) in the rat brain. Given the interaction between the pineal hormone, melatonin, and GABAergic systems in the central nervous system, the effects of VPA on the expression of the mammalian melatonin receptor subtypes, MT 1 and MT 2 , were examined in rat C6 glioma cells. The effects of VPA on the expression of glial cell line-derived neurotrophic factor (GDNF) and BDNF were also examined. RT-PCR studies revealed a significant induction of melatonin MT 1 receptor mRNA in C6 cells following treatment with 3 or 5 mM VPA for 24 h or 5 mM VPA for 48 h. Western analysis and immunocytochemical detection confirmed that the VPA-induced increase in MT 1 mRNA results in up-regulation of MT 1 protein expression. Blockade of the MAPK-ERK pathway by PD98059 enhanced the effect of VPA on MT 1 expression, suggesting a negative role for this pathway in MT 1 receptor regulation. In addition, significant increases in BDNF, GDNF and HDAC mRNA expression were observed after treatment with VPA for 24 or 48 h. Taken together, the present findings suggest that the neuroprotective properties of VPA involve modulation of neurotrophic factors and receptors for melatonin, which is also thought to play a role in neuroprotection. Moreover, the foregoing suggests that combinations of VPA and melatonin could provide novel therapeutic strategies in neurological and psychiatric disorders. Keywords: brain-derived neurotrophic factor, glial cell linederived neurotrophic factor, histone acetylation, melatonin MT 1 and MT 2 receptors, mitogen-activated protein kinaseextracellular signal-regulated kinase pathway, neuroprotection.

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“…Stimulation of MT1 is also accompanied by an elevation of the phosphorylation of mitogen-activated protein kinase MEK1/2 as well as extracellular signalregulated kinase [174]. Furthermore, activation of the MT1 receptor also increases potassium conductance by activating Kir3 (GIRK) inward rectifier potassium channels [175] and potentiates prostaglandin F 2 a and ATP mediated stimulation of the activity of protein kinase C (PKC) [176].…”

Section: Melatonin: Receptors and Signal Transductionmentioning

confidence: 99%

An insight into the scientific background and future perspectives for the potential uses of melatonin

Anwar

Muhammad²,

Bader³

et al. 2015

Egyptian Journal of Basic and Applied Sciences

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Antiepileptic Antiosteoporotic Antioxidant Cardiovascular disease Circardian rhythm Hypnotic Immunodulatory Melatonin a b s t r a c t Melatonin is one of the most versatile and ubiquitous molecule widely distributed in nature has been reported to play a role in a wide variety of physiological responses including reproduction, circadian homeostasis, sleep, retinal neuromodulation, and vasomotor responses. In most vertebrates, including humans, melatonin is synthesized primarily in the pineal gland and is regulated by the environmental light ⁄ dark cycle via the suprachiasmatic nucleus. Melatonin is synthesized in all areas of the body such as gastrointestinal tract, skin, bone marrow, retina and in lymphocytes, from which it may influence other physiological functions through paracrine signalling. In addition to regulation of circadian rhythm of melatonin a variety of other physiological effects such as hypnotic, antidepressant, antiepileptic, oncostatic, immunomodulatory, antiosteoporotic, in cardiovascular disease, neuromodulatory and cerebral ischaemic condition have been reported.Moreover there is scarcity of literature that reviewed the scientific evidence for its use in these conditions. Therefore in this article we review recent advances in this research field, which is preceded by a concise account of general information about melatonin, melatonin receptors and intracellular signalling pathways for melatonin actions.

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Melatonin induction of filamentous structures in non-neuronal cells that is dependent on expression of the human mt1 melatonin receptor

Cited by 70 publications

References 61 publications

Driving GDNF expression: The green and the red traffic lights

Driving GDNF expression: The green and the red traffic lights

Novel targets for valproic acid: up‐regulation of melatonin receptors and neurotrophic factors in C6 glioma cells

An insight into the scientific background and future perspectives for the potential uses of melatonin

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