Melatonin inhibits apoptosis during early B‐cell development in mouse bone marrow

Yu, Qingnan; Miller, Sandra C.; Osmond, Dennis G.

doi:10.1034/j.1600-079x.2000.290204.x

Cited by 63 publications

(41 citation statements)

References 31 publications

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“…Such a predominant effect on CD4+ cells is supported by the observations on melatonin efficacy to augment CD4+ cells in submaxillary lymph nodes [79]. However, expression of the Mel 1a -melatonin receptor was found in the rat thymus and spleen, melatonin receptor mRNA being expressed in all the thymic lymphocyte subpopulations (CD4+, CD8+, double-positive, double-negative, and B cells), indicating possible effects of melatonin on all these cells [123,133]. Nuclear melatonin receptors may also mediate immunomodulation, since drugs that bind to RZR/ROR receptors are active in experimental models of autoimmune diseases [100].…”

Section: Melatonin Is a Circadian Immunoregulatory Signalsupporting

confidence: 55%

“…Melatonin also stimulates NK cell activity [116,117], activates monocytes [118], increases the number of Th-2 lymphocytes [119], augments CD4+ lymphocytes and decreased CD8+ lymphocytes in submaxillary lymph nodes [79], restores impaired Th cell activity in immunodepressed mice [120], and augments antibody responses in vivo [103,108,113,121,122]. Concerning B cells, there is information on melatonin inhibition of apoptosis during early B-cell development in mouse bone marrow [123].…”

Section: Melatonin Is a Circadian Immunoregulatory Signalmentioning

confidence: 99%

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Circadian Disorganization in Experimental Arthritis

Cardinali

Esquifino²

2003

Neurosignals

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This review discusses the experimental evidence indicating that arthritis disrupts circadian organization, which was mainly derived from animal studies employing Freund’s complete mycobacterial adjuvant (FCA). The defense response to antigenic challenge, mediated in part by cytokines, includes changes in chronobiological central nervous system function, like depressed daily activity, superficial sleep or anorexia. Interferon (IFN)-γ receptors are detectable in the central circadian pacemaker, the hypothalamic suprachiasmatic nuclei, at a time when the capacity for photic entrainment of the pacemaker became established. The disruptive effects of the systemic injection of IFN on the circadian rhythms of locomotor activity, body temperature and clock-gene mRNA expression have been documented. In the last few years we have examined a number of immune and neuroendocrine circadian rhythms in FCA-injected rats, both in the preclinical phase of arthritis (2–3 days after FCA injection) as well as in the acute phase of the disease (18 days after FCA injection). In arthritic rats, the 24-hour organization of immune and neuroendocrine responses becomes altered. A hormonal pathway involving the circadian secretion of melatonin and a purely neural pathway including, as a motor leg, the autonomic nervous system innervating the lymph nodes were identified. The significant effects of the immune-mediated inflammatory response on the diurnal rhythmicity of adenohypophysial and hypophysiotropic hormones occurred in arthritic rats. Melatonin treatment prevented the alteration in 24-hour rhythms of serum ACTH, prolactin and luteinizing hormone in rats injected with FCA. In addition, melatonin pretreatment prevented the alteration in the 24-hour variation in hypothalamic serotonin and dopamine turnover during the preclinical phase of Freund’s adjuvant arthritis in rats. Some pinealectomy-induced immune changes in arthritic rats were also prevented by physiological concentrations of melatonin. Melatonin may play the role of an ‘internal synchronizer’ for the immune system.

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Section: Melatonin Is a Circadian Immunoregulatory Signalsupporting

confidence: 55%

Section: Melatonin Is a Circadian Immunoregulatory Signalmentioning

confidence: 99%

Circadian Disorganization in Experimental Arthritis

Cardinali

Esquifino²

2003

Neurosignals

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“…In particular, melatonin was shown to regulate the apoptosis of B and T cells [103,104]. Indeed, melatonin inhibits apoptosis of precursor B cells in mouse bone marrow [105]. Moreover, an anti-apoptotic effect on different leukocytes was also demonstrated [23,102].…”

Section: Page 9 Of 29mentioning

confidence: 97%

Melatonin: A pleiotropic molecule regulating inflammation

Radogna

Diederich

Ghibelli

2010

Biochemical Pharmacology

308

247

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Melatonin is a neurohormone produced by the pineal gland that regulates sleep and circadian functions. Melatonin also regulates inflammatory and immune processes acting as both an activator and inhibitor of these responses. Melatonin demonstrates endocrine, but also paracrine and autocrine effects in the leukocyte compartment: on one side, leukocytes respond to melatonin in a circadian fashion; on the other side, leukocytes are able to synthesize melatonin by themselves.With its endocrine and paracrine effects, melatonin differentially modulates pro-inflammatory enzymes, controls production of inflammatory mediators such as cytokines and leukotrienes and regulates the lifespan of leukocytes by interfering with apoptotic processes. Moreover, its potent anti-oxidant ability allows scavenging of oxidative stress in the inflamed tissues. The interesting timing of pro-and anti-inflammatory effects, such as those affecting lipoxygenase activity, suggests that melatonin might promote early phases of inflammation on one hand and contribute to its attenuation on the other hand, in order to avoid complications of chronic inflammation. This review aims at giving a comprehensive overview of the various inflammatory pathways regulated by this pleiotropic hormone.

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“…Melatonin can modulate proliferation and cytokine secretion via these receptors on immune cells (García-Mauriño et al 2000;GarciaMaurino et al 1997). The administration of melatonin can improve the survival and increase the numbers of precursor B and NK cells in bone marrow (Yu et al 2000;Currier et al 2000). Ionizing radiation has a potent effect on immune cells such as T and B lymphocytes.…”

Section: Role Of Melatonin In Immune Responses To Radiationmentioning

confidence: 99%

The melatonin immunomodulatory actions in radiotherapy

et al. 2017

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Radiotherapy has a key role in cancer treatment in more than half of patients with cancer. The management of severe side effects of this treatment modality is a limiting factor to appropriate treatment. Immune system responses play a pivotal role in many of the early and late side effects of radiation. Moreover, immune cells have a significant role in tumor response to radiotherapy, such as angiogenesis and tumor growth. Melatonin as a potent antioxidant has shown appropriate immune regulatory properties that may ameliorate toxicity induced by radiation in various organs. These effects are mediated through various modulatory effects of melatonin in different levels of tissue reaction to ionizing radiation. The effects on the DNA repair system, antioxidant enzymes, immune cells, cytokines secretion, transcription factors, and protein kinases are most important. Moreover, anti-cancer properties of melatonin may increase the therapeutic ratio of radiotherapy. Clinical applications of this agent for the management of malignancies such as breast cancer have shown promising results. It seems anti-proliferative, anti-angiogenesis, and stimulation or suppression of some immune cell responses are the main anti-tumor effects of melatonin that may help to improve response of the tumor to radiotherapy. In this review, the effects of melatonin on the modulation of immune responses in both normal and tumor tissues will be discussed.

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Melatonin inhibits apoptosis during early B‐cell development in mouse bone marrow

Cited by 63 publications

References 31 publications

Circadian Disorganization in Experimental Arthritis

Circadian Disorganization in Experimental Arthritis

Melatonin: A pleiotropic molecule regulating inflammation

The melatonin immunomodulatory actions in radiotherapy

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