Melatonin protects inner ear against radiation damage in rats

Karaer, Işıl Çakmak; Şimşek, Gökçe; Gül, Mehmet; Bahar, Leyla; Gurocak, Simay; Parlakpınar, Hakan; Nuransoy, Ayse

doi:10.1002/lary.25376

Cited by 18 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, α-lipoic acid (LA) is an endogenously produced co-factor of an enzyme that plays an important role in α-ketoacid dehydrogenase reactions [ 8 , 9 ]. MLT and LA are both effective endogenous ROS scavengers that have been shown to provide protection against IR injury [ 10 , 11 , 12 , 13 ]. In this study, LA was used as the substrate to synthesize a new compound by inserting the MLT amino acid functional groups related to anti-radical, anti-radiation, and immune activity.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of 5-Methoxytryptamine-α-lipoic Acid on Ionizing Radiation-Induced Hematopoietic Injury

Tian

Tang

et al. 2016

IJMS

View full text Add to dashboard Cite

Antioxidants are prospective radioprotectors because of their ability to scavenge radiation-induced reactive oxygen species (ROS). The hematopoietic system is widely studied in radiation research because of its high radiosensitivity. In the present study, we describe the beneficial effects of 5-methoxytryptamine-α-lipoic acid (MLA), which was synthesized from melatonin and α-lipoic acid, against radiation-induced hematopoietic injury. MLA administration significantly enhanced the survival rate of mice after 7.2 Gy total body irradiation. The results showed that MLA not only markedly increased the numbers and clonogenic potential of hematopoietic cells but also decreased DNA damage, as determined by flow cytometric analysis of histone H2AX phosphorylation. In addition, MLA decreased the levels of ROS in hematopoietic cells by inhibiting NOX4 expression. These data demonstrate that MLA prevents radiation-induced hematopoietic syndrome by increasing the number and function of and by inhibiting DNA damage and ROS production in hematopoietic cells. These data suggest MLA is beneficial for the protection of radiation injuries.

show abstract

Section: Introductionmentioning

confidence: 99%

The Protective Effects of 5-Methoxytryptamine-α-lipoic Acid on Ionizing Radiation-Induced Hematopoietic Injury

Tian

Tang

et al. 2016

IJMS

View full text Add to dashboard Cite

show abstract

“…DPOAE amplitudes both in a and b groups reached better values than they did in group d. Microscopically, damage to the organs of Corti, spiral ganglions, and stria vascularis damage was reduced in both a and b groups when compared with the group c. 5 mg/Kg/day 5 days [51] 50 guinea pigs divided into 5 groups, exposed to 60 h of continuous wide band noise at high intensity (except Comparing group b with a, it was found that the malondialdehyde activity of the plasma and tissue 20 mg/Kg/day 2.5 days (a) control group (not treated and not exposed); (b) exposed to noise and not treated group; (c) exposed to noise and treated with melatonin; (d) exposed to noise and treated with methylprednisolone; (e) exposed to noise and treated with melatonin and methylprednisolone.…”

Section: Igf-1mentioning

confidence: 77%

“…Normal OAE reappeared within 5 days when gentamicin or tobramycin was administered in combination with MT, without interference with the antibiotic function of aminoglycosides [50]. In addition, one study showed that administration of MT after or even before ionizing radiation might prevent high frequency hearing loss [51]. [52] gave an explanation of its effectiveness.…”

Section: Tinnitus: Otoprotective Properties Of Melatoninmentioning

confidence: 99%

Hormone Therapy: Challenges for Treating Hearing Impairments

Guerra¹,

Devesa²

2019

SN Compr. Clin. Med.

View full text Add to dashboard Cite

The purpose of this review is to summarize the advances and discoveries in the potential treatment with hormone analogs and some challenges still pending, beyond the classic treatment with corticosteroids. We conduct a review of the functions of hormones on hearing, in human and animal models, the presence of their most relevant receptors, and the desirable and undesirable effects for their therapeutic uses. Different hormones play a regulatory role in the development and maintenance of hearing. Hormone receptors in the ear have been identified over the years, which can be a support to use them as new therapeutic targets Moreover, their mediators, that include cells, neurotrophic factors, or other hormones, could be also useful for treating various hearing impairments The use of synthetic analogs could exert a therapeutic effect on hearing. Hormone therapy, in fact, can contribute positively to the treatment and prevention of various auditory pathologies, through the regeneration or protection. Considering that an optimal result has to be a garantee, it is a must to know their unwanted effects and contraindications. The use of hormones may protect, regenerate, and modulate multiple pathological conditions of the ear, but it would be necessary to standardize drug dosages, find alternative routes, and conduct prospective studies in humans.

show abstract

“…Paraffin-embedded specimens were cut into 5-6-µm thick sections, mounted on slides and stained with hematoxylin and eosin. [17] Sections of tympanic bullae were examined using a Nikon Optiphot-2 light microscope and analyzed using the Nikon DS-L3 Image Analysis System (Nikon Corporation, Tokyo, Japan). Tissue alterations in each specimen were assessed in the organ of Corti, stria vascularis and spiral ganglia by an experienced histologist who was blinded to the groups.…”

Section: Methodsmentioning

confidence: 99%

Effect of hyperbaric oxygen on hyperglycemia-induced cochlear damage: An experimental study

Yiğider¹

2019

KBB Uygulamaları

View full text Add to dashboard Cite

Bu çalışmada diabetes mellituslu sıçanlarda hiperglisemiye bağlı koklear hasarın hiperbarik oksijen terapisi (HBOT) ile tedavi edilip edilemeyeceği distorsiyon ürünü otoakustik emisyon (DÜOAE) ve histopatolojik analiz kullanılarak araştırıldı. Gereç ve Yöntemler: Çalışmaya 18 erkek albino Sprague Dawley sıçan (≥350 g ağırlığında, en az iki aylık) dahil edildi. Hayvanlar kontrol grubu (grup 1), streptozosin (STZ) ile indüklenmiş diyabet grubu (grup 2) ve STZ ile indüklenmiş diyabet+HBOT grubu (grup 3) olmak üzere üç gruba ayrıldı. Kokleanın fonksiyonel durumunu göstermek için başlangıçta ve sekizinci haftanın sonunda DÜOAE kullanıldı. Grup 3 altıncı haftada bir hafta boyunca HBOT ile tedavi edildi. Sekizinci haftanın sonunda tüm hayvanlar dekapite edildi. Histolojik değerlendirme ışık mikroskopisi altında yapıldı. Bulgular: Grup 2 ve 3'teki tüm hayvanlarda açlık kan şekeri >250 mg/ dL idi. Çalışmanın sonunda sinyal gürültü oranı değerleri açısından gruplar arasında 2 kHz'in grup 2 ve 3'te daha düşük olması dışında farklılık yoktu. Histolojik değerlendirme hidropik dejenerasyon, destek ve saç hücrelerinde kayıp, baziler membran deformasyonu ve skala mediada fibrinoid materyal birikimi dahil dejenerasyonların grup 2'de grup 3'ten daha yüksek olduğunu gösterdi. Sonuç: Çalışmamızda HBOT diyabete bağlı koklear hasarı histolojik olarak azalttı. Bulgularımız ışığında, eğer doğru algoritma oluşturulabilirse diyabetiklerde işitme kaybının tedavisi önemli ölçüde gelişebilir. Anahtar sözcükler: Koklea, diabetes mellitus, distorsiyon ürünü otoakustik emisyon, hiperbarik oksijen. ABSTR ACT Objectives: This study aims to investigate whether hyperglycemiainduced cochlear damage can be treated with hyperbaric oxygen therapy (HBOT) in rats with diabetes mellitus using distortion product otoacoustic emission (DPOAE) and histopathological analysis. Materials and Methods: The study included 18 male albino Sprague Dawley rats (weighing ≥350 g, at least two months of age). Animals were divided into three groups as the control group (group 1), streptozocin (STZ)-induced diabetes group (group 2), and STZ-induced diabetes+HBOT group (group 3). Distortion product otoacoustic emission was used to demonstrate functional status of cochlea and applied at the beginning and at the end of the eighth week. Group 3 was treated with HBOT for one week at sixth week. By the end of the eighth week, all animals were decapitated. Histological evaluation was performed under light microscopy. Results: All animals in groups 2 and 3 had fasting blood glucose levels >250 mg/dL. There was no difference in terms of signal-to-noise ratio values between groups at the end of the study except for 2 kHz, which was lower in groups 2 and 3. Histological evaluation showed that degenerations including hydropic degeneration, loss of supporting and hair cells, basilar membrane deformation, and fibrinoid material in deposition in the scala media were higher in group 2 than group 3. Conclusion: In our study, HBOT ameliorated diabetes-induced cochlear damage histologically. ...

show abstract

Melatonin protects inner ear against radiation damage in rats

Abstract: These results indicate that melatonin may have significant ameliorative effects on cochlear damage secondary to ionizing radiation.

Cited by 18 publications

References 36 publications

The Protective Effects of 5-Methoxytryptamine-α-lipoic Acid on Ionizing Radiation-Induced Hematopoietic Injury

The Protective Effects of 5-Methoxytryptamine-α-lipoic Acid on Ionizing Radiation-Induced Hematopoietic Injury

Hormone Therapy: Challenges for Treating Hearing Impairments

Effect of hyperbaric oxygen on hyperglycemia-induced cochlear damage: An experimental study

Contact Info

Product

Resources

About