Melatonin role preventing steatohepatitis and improving liver transplantation results

Esteban‐Zubero, Eduardo; García-Gil, Francisco A.; López-Pingarrón, Laura; Alatorre-Jiménez, Moisés Alejandro; Ramı́rez, José M.; Tan, Dun Xian; Garcia, J.; Reíter, Russel J.

doi:10.1007/s00018-016-2185-2

Cited by 15 publications

(7 citation statements)

References 194 publications

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“…By all indices, the benefits of melatonin exceed those of AA and suggest tests of this important molecule in additional transplantation studies, including in clinical trials. The findings related to the likely utility of melatonin in organ transplantation have recently been reviewed, and, in a separate report, melatonin was also suggested for use in ovary transplantation …”

Section: Melatonin As An Antioxidant: Waging War On Free Radicalsmentioning

confidence: 99%

Melatonin as an antioxidant: under promises but over delivers

Reíter

Mayo

Tan

et al. 2016

Journal of Pineal Research

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1,312

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Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large number of circumstances. It achieves this action via a variety of means: direct detoxification of reactive oxygen and reactive nitrogen species and indirectly by stimulating antioxidant enzymes while suppressing the activity of pro-oxidant enzymes. In addition to these well-described actions, melatonin also reportedly chelates transition metals, which are involved in the Fenton/Haber-Weiss reactions; in doing so, melatonin reduces the formation of the devastatingly toxic hydroxyl radical resulting in the reduction of oxidative stress. Melatonin's ubiquitous but unequal intracellular distribution, including its high concentrations in mitochondria, likely aid in its capacity to resist oxidative stress and cellular apoptosis. There is credible evidence to suggest that melatonin should be classified as a mitochondria-targeted antioxidant. Melatonin's capacity to prevent oxidative damage and the associated physiological debilitation is well documented in numerous experimental ischemia/ reperfusion (hypoxia/reoxygenation) studies especially in the brain (stroke) and in the heart (heart attack). Melatonin, via its antiradical mechanisms, also reduces the toxicity of noxious prescription drugs and of methamphetamine, a drug of abuse.Experimental findings also indicate that melatonin renders treatment-resistant cancers sensitive to various therapeutic agents and may be useful, due to its multiple antioxidant actions, in especially delaying and perhaps treating a variety of agerelated diseases and dehumanizing conditions. Melatonin has been effectively used to combat oxidative stress, inflammation and cellular apoptosis and to restore tissue function in a number of human trials; its efficacy supports its more extensive use in a wider variety of human studies. The uncommonly high-safety profile of melatonin also bolsters this conclusion. It is the current feeling of the authors that, in view of the widely diverse beneficial functions that have been reported for melatonin, these may be merely epiphenomena of the more fundamental, yet-to-be identified basic action(s) of this ancient molecule. K E Y W O R D Sdiseases of aging, drug toxicity, free radicals, ischemia/reperfusion, mitochondria-targeted antioxidant, organ transplantation, statins

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Section: Melatonin As An Antioxidant: Waging War On Free Radicalsmentioning

confidence: 99%

Melatonin as an antioxidant: under promises but over delivers

Reíter

Mayo

Tan

et al. 2016

Journal of Pineal Research

Self Cite

1,312

1,040

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“…It also has therapeutic potential for respiratory, colonic, autoimmune, adult-onset chronic non-communicable diseases, ischemic brain and cardiovascular injury, circadian disturbance, stroke, steatohepatitis, etc. [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. Melatonin can efficiently scavenge a variety of ROS including hydrogen peroxide (H 2 O 2 ), hydroxyl radical (HO•), nitric oxide (NO•), singlet oxygen ( 1 O 2 ) and superoxide anion (O 2– •) [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Melatonin in Apples and Juice: Inhibition of Browning and Microorganism Growth in Apple Juice

Zhang

Chen

et al. 2018

Molecules

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Synthetic melatonin (N-acetyl-5-methoxytryptamine, MT) is popular in the US and Asian markets as a health supplement. Here, we identified a naturally occurring melatonin source in apple juice. Melatonin was present in all 18 apple cultivars tested. The highest melatonin level of the edible part of apple was detected in the apple peel. The melatonin content in ‘Fuji’ apple juice is comparable to the level of its flesh. Melatonin was consumed during the process of juicing due to its interaction with the oxidants. Melatonin addition significantly reduced the juice color change to brown (browning). The mechanism is that melatonin scavenges the free radicals, which was indicated by the ASBT analysis; therefore, inhibiting the conversion of o-diphenolic compounds into quinones. Most importantly, melatonin exhibited powerful anti-microorganism activity in juice. The exact mechanisms of this action are currently unknown. These effects of melatonin can preserve the quality and prolong the shelf life of apple juice. The results provide valuable information regarding commerciall apple juice processing and storage.

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“…Studies in murine models have suggested that hepatocyte injury and inflammation are the primary contributors that aggravate the injury in steatotic liver IR injury [ 142 , 143 , 144 ]. Li et al have shown an increase in necrotic area along with increases in TNFα, IL-6 and interferon-γ (IFN-γ) after IR injury in methionine, choline-deficient and high-fat (MCDHF) diet fed mice [ 143 ].…”

Section: Necroptosis In Steatotic Hepatic Injury and Steatotic Ir mentioning

confidence: 99%

Necroptosis in Hepatosteatotic Ischaemia-Reperfusion Injury

Baidya

Crawford

Gautheron

et al. 2020

IJMS

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While liver transplantation remains the sole treatment option for patients with end-stage liver disease, there are numerous limitations to liver transplantation including the scarcity of donor livers and a rise in livers that are unsuitable to transplant such as those with excess steatosis. Fatty livers are susceptible to ischaemia-reperfusion (IR) injury during transplantation and IR injury results in primary graft non-function, graft failure and mortality. Recent studies have described new cell death pathways which differ from the traditional apoptotic pathway. Necroptosis, a regulated form of cell death, has been associated with hepatic IR injury. Receptor-interacting protein kinase 3 (RIPK3) and mixed-lineage kinase domain-like pseudokinase (MLKL) are thought to be instrumental in the execution of necroptosis. The study of hepatic necroptosis and potential therapeutic approaches to attenuate IR injury will be a key factor in improving our knowledge regarding liver transplantation with fatty donor livers. In this review, we focus on the effect of hepatic steatosis during liver transplantation as well as molecular mechanisms of necroptosis and its involvement during liver IR injury. We also discuss the immune responses triggered during necroptosis and examine the utility of necroptosis inhibitors as potential therapeutic approaches to alleviate IR injury.

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Melatonin role preventing steatohepatitis and improving liver transplantation results

Cited by 15 publications

References 194 publications

Melatonin as an antioxidant: under promises but over delivers

Melatonin as an antioxidant: under promises but over delivers

Melatonin in Apples and Juice: Inhibition of Browning and Microorganism Growth in Apple Juice

Necroptosis in Hepatosteatotic Ischaemia-Reperfusion Injury

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