Melatonin treatment during early life interacts with restraint to alter neuronal morphology and provoke depressive-like responses

Aubrecht, Taryn G.; Weil, Zachary M.; Nelson, Randy J.

doi:10.1016/j.bbr.2014.01.025

Cited by 4 publications

(2 citation statements)

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“…2e). However, MyT1 overexpression decreased the number of fecal boli produced during the OF test, an anxiolytic-like response (Aubrecht et al 2014;F (1, 16) = 4.998, p = 0.040; Fig. 2f).…”

Section: Anxiety-like Behaviormentioning

confidence: 92%

“…The tendency of a rat to enter this center zone was used as an indication of anxiolytic-like phenotype. The anxiogenic-like phenotype was supported by increased number of fecal boli left in the arena (Amorim et al 2014;Aubrecht et al 2014;Ghisleni et al 2008). After each session, fecal boli were counted and removed, and the open field arena was cleaned with a 70% pure ethanol solution to remove odor trails.…”

Section: Anxiety-and Ethanol-related Behavior Testsmentioning

confidence: 99%

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Viral-mediated overexpression of the Myelin Transcription Factor 1 (MyT1) in the dentate gyrus attenuates anxiety- and ethanol-related behaviors in rats

Bahí

Dreyer

2017

Psychopharmacology

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Rationale Myelin Transcription Factor 1 (MyT1), a member of the Zinc Finger gene family, plays a fundamental role in the nervous system. Recent research has suggested that this transcription factor is associated with the pathophysiology of psychiatric disorders including addiction, schizophrenia, and depression. However, the role of MyT1 in anxiety-and ethanolrelated behaviors is still unknown. Objectives We evaluated the effects of lentiviral-mediated overexpression of MyT1 in the dentate gyrus (DG) on anxiety-and ethanol-related behaviors in rats. Methods We used the elevated plus maze (EPM) and the open field (OF) tests to assess anxiety-like behavior and a twobottle choice procedure to measure the effects of MyT1 on ethanol intake and preference. Results MyT1 overexpression produced anxiolytic-like effects in the EPM test and decreased the number of fecal boli in the OF test, without affecting locomotor activity in both behavioral tests. Next, we demonstrated that ethanol intake and preference were decreased in the MyT1-overexpressing rats with no effect on saccharin and quinine, used to assess taste discrimination, and no effect on ethanol clearance suggesting specific alterations in the rewarding effects of ethanol.Most importantly, ectopic MyT1 overexpression increased both MyT1 and BDNF mRNA levels in the DG. Using Pearson's correlation, results showed a strong negative relationship between MyT1 mRNA and anxiety parameters and ethanol consumption and a positive correlation between MyT1 and BDNF mRNAs. Conclusion Taken together, MyT1 along with being a key component in anxiety may be a suitable candidate in the search of the molecular underpinnings of alcoholism.

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“…2e). However, MyT1 overexpression decreased the number of fecal boli produced during the OF test, an anxiolytic-like response (Aubrecht et al 2014;F (1, 16) = 4.998, p = 0.040; Fig. 2f).…”

Section: Anxiety-like Behaviormentioning

confidence: 92%

Section: Anxiety-and Ethanol-related Behavior Testsmentioning

confidence: 99%

Viral-mediated overexpression of the Myelin Transcription Factor 1 (MyT1) in the dentate gyrus attenuates anxiety- and ethanol-related behaviors in rats

Bahí

Dreyer

2017

Psychopharmacology

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The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders

Tchekalarova

Moyanova

Fusco

et al. 2015

Brain Research Bulletin

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Abstract\ud \ud There is emerging evidence of the beneficial role of the melatonin system in a wide range of psychiatric and neurologic disorders, including anxiety, depression, and epilepsy. Although melatoninergic drugs have chronobiotic and antioxidant properties that positively influence circadian rhythm desynchronization and neuroprotection in neurodegenerative disorders, studies examining the use of melatonin for epilepsy's comorbid psychiatric and neurological symptomatology are still limited. Preclinical and clinical findings on the beneficial effects of the melatonin system on anxiety, depression, and epilepsy suggest that melatoninergic compounds might be effective in treating comorbid behavioral complications in epilepsy beyond regulation of a disturbed sleep-wake cycle

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Influence of gonadal hormones on the behavioral effects of intermittent hypoxia in mice

Aubrecht

Jenkins

Magalang

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Obstructive sleep apnea (OSA) is characterized by repetitive upper airway obstruction resulting in cyclic intermittent hypoxia (IH) during sleep in affected individuals. OSA occurs more frequently in postmenopausal than premenopausal women and the severity of OSA increases after menopause. Gonadal hormones can influence brain and behavior; testosterone and estrogens in particular can enhance spatial learning and memory. We hypothesized that estrogens may protect mice from IH-induced hippocampal morphological and behavioral changes. To test this hypothesis we exposed intact or gonadectomized male and female mice to room air or IH [15 cycles/h, 8 h/day, fraction of inspired oxygen (FiO 2) nadir of 5%] for a total of 30 days. During the final 4 days of IH, mice were tested for anxiety- and depressive-like behaviors. After cessation of IH exposure mice were tested on the Barnes maze and passive avoidance tests to assess learning and memory. Ovariectomy paired with IH treatment, impaired spatial learning and memory compared to all other female groups. Intact male mice receiving IH treatment also had impaired learning and memory compared with intact or castrated male mice exposed to room air. Learning and memory changes were mirrored by changes in basilar dendritic length of the CA1 region of the hippocampus. These data suggest that estrogens provide protection against IH-induced deficits, whereas androgens partially exacerbate IH-induced deficits on learning and memory.

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Melatonin treatment during early life interacts with restraint to alter neuronal morphology and provoke depressive-like responses

Cited by 4 publications

References 40 publications

Viral-mediated overexpression of the Myelin Transcription Factor 1 (MyT1) in the dentate gyrus attenuates anxiety- and ethanol-related behaviors in rats

Viral-mediated overexpression of the Myelin Transcription Factor 1 (MyT1) in the dentate gyrus attenuates anxiety- and ethanol-related behaviors in rats

The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders

Influence of gonadal hormones on the behavioral effects of intermittent hypoxia in mice

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