Members of a highly widespread bacteriophage family are hallmarks of metabolic syndrome gut microbiomes

Abstract

There is significant interest in altering the course of cardiometabolic disease development via the gut microbiome. Nevertheless, the highly abundant viral members -which impact gut bacteria- of the complex gut ecosystem remain understudied. Here, we characterized gut virome changes associated with metabolic syndrome (MetS), a highly prevalent clinical condition preceding cardiometabolic disease. MetS gut virome populations exhibited decreased richness and diversity, but larger inter-individual variation. These populations were enriched in phages infecting Bacteroidaceae and depleted in those infecting Ruminococcaeae. Differential abundance analysis identified eighteen viral clusters (VCs) as significantly associated with either MetS or healthy viromes. Among these are a MetS-associated Roseburia VC that is related to healthy control-associated Faecalibacterium and Oscillibacter VCs. Further analysis of these VCs revealed the Candidatus Heliusviridae, a highly widespread gut phage lineage found in 90+% of the participants. The temperate Ca. Heliusviridae are important novel research targets for understanding the role of the microbiome in human cardiometabolic health and developing microbiome-targeted interventions.

Caracterização do microbioma em úlcera de perna de pacientes com Doença Falciforme

“…Outros componentes comumente identificados na metagenômica são os vírus, os fungos e os fagos, sendo esse último fundamental, pois alteram a composição e abundância de comunidades bacterianas (82). Acrescentamos ainda que a metabolômica, que também não foi objeto do estudo atual, complementa a compreensão de estudos acerca do microbioma, pois investiga a relação de micro-organismos com os metabólitos identificados, direcionando vias ou funções especializadas no ambiente das úlceras de perna da DF.…”