Membrane-active properties and antiradical activity of gossypol and its derivatives

Tukfatullina, I. I.; Tilyabaev, K. Z.; Mamadrakhimov, A.; Salakhutdinov, B. A.; Камаев, Ф. Г.; Yuldashev, A. M.; Dowd, Michael K.; Talipov, S. A.; Ибрагимов, Б. Т.; Aripov, T. F.

doi:10.1007/s10600-008-9087-y

Cited by 9 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results of comparative studies of acute toxicity [21], antifungal activity [19] and cytotoxicity on K562 human leukemia line cells [32] of gossypol and its Schiff bases suggest that, in general, the less is number of free aldehyde groups the lower is the activity of compound (gossypol>gossypol half-Schiff bases >gossypol bis-Schiff bases). Studies on antiradical and membranotropic activity [33] of investigated compounds also confirmed the above-mentioned correlation.…”

Section: Unsymmetrical Mono-and Bis-derivatives Of Gossypol: Synthesis Structure Biological Propertiessupporting

confidence: 76%

Unsymmetrical Derivatives of Gossypol: A Review

Tiliabaev

2013

JCPRM

View full text Add to dashboard Cite

show abstract

Section: Unsymmetrical Mono-and Bis-derivatives Of Gossypol: Synthesis Structure Biological Propertiessupporting

confidence: 76%

Unsymmetrical Derivatives of Gossypol: A Review

Tiliabaev

2013

JCPRM

View full text Add to dashboard Cite

show abstract

“…A large number of gossypol derivatives, such as Schiff's bases, esters, and ethers have been prepared. Several gossypol derivatives and analogs, such as compounds 3-6, possess activities such as antimalarial, anti-cancer, HIV (human immunodeficiency virus), and antiparasitic properties [31][32][33][34][35][36][37]. High throughput screening studies on a gossypol derivative 5 were performed in vivo and in vitro.…”

Section: Resultsmentioning

confidence: 99%

Identification of natural products and their derivatives as promising inhibitors of protein glycation with non-toxic nature against mouse fibroblast 3T3 cells

Abbas¹,

Al-Harrasi²,

Hussain³

et al. 2017

ijpm

View full text Add to dashboard Cite

A b s t r a c tThis study was performed to identify new inhibitors of protein glycation glycation is one of the major causes of late diabetic complications. In this study, terpenoids and alkaloids, isolated from different medicinal plants, along with their derivatives, were evaluated for their antiglycation activity to assess their potential cytotoxicity. Among the tested compounds, gossypol (2,2 1,6,7 and its derivat gazolidone (6), showed a potent antiglycation activity (IC aminoantipyrine (5) showed a significant antiglycation activity with IC µM, in BSA methyl isolated from aphyllin significant inhibition activity with 110.203±4.816µM, respectively. Similarly, compounds gossypol deoxypeganine hydrochloride (8), with IC respectively. The results were compared with the = Cellular cytotoxicity assay showed only gossypol acetic acid (2) and gossypolidene thiocarbamide (3) as somewhat toxic to 3T3 (mouse fibroblast) cells with IC ±0.61 and 5.00 with IC

show abstract

“…Cottonseed oil (CSO) is unique in that it contains a small percentage (0.1 to 0.2% of crude oil) of gossypol ( Fig. 1), which has been demonstrated to possess antioxidant properties [2][3][4][5]. To date the influence of exogenous gossypol on the oxidative stability of biodiesel has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Improvement of fuel properties of cottonseed oil methyl esters with commercial additives

Joshi

Moser

Shah

et al. 2010

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

The low temperature operability and oxidative stability of cottonseed oil methyl esters (CSME) were improved with four anti-gel additives as well as one antioxidant additive, gossypol. Low temperature operability and oxidative stability of CSME was determined by cloud point (CP), pour point (PP), cold filter plugging point (CFPP), and oxidative stability index (OSI). The most significant reductions in CP, PP, and CFPP in all cases were obtained with Technol 1 , with the average reduction in temperature found to be 3.9 8C. Gunk 1 , Heet 1 , and Howe's 1 were progressively less effective, as indicated by average reductions in temperature of 3.4, 3.0, and 2.8 8C, respectively. In all cases, the magnitude of CFPP reduction was greater than for PP and especially CP. Addition of gossypol, a polyphenolic aldehyde, resulted in linear improvement in OSI (R 2 ¼ 0.9804). The OSI of CSME increased from 5.0 to 8.3 h with gossypol at a concentration of 1000 ppm.

show abstract

Membrane-active properties and antiradical activity of gossypol and its derivatives

Cited by 9 publications

References 11 publications

Unsymmetrical Derivatives of Gossypol: A Review

Unsymmetrical Derivatives of Gossypol: A Review

Identification of natural products and their derivatives as promising inhibitors of protein glycation with non-toxic nature against mouse fibroblast 3T3 cells

Improvement of fuel properties of cottonseed oil methyl esters with commercial additives

Contact Info

Product

Resources

About