Membrane anchoring γ-secretase modulators with terpene-derived moieties

Naumann, Eva Christine; Göring, Stefan; Ogorek, Isabella; Weggen, Sascha; Schmidt, Boris

doi:10.1016/j.bmcl.2013.04.070

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…It could also play an anti‐AD role by inhibiting p38 and nuclear factor‐κB signaling pathway, reducing the production of nitric oxide and glycogen synthase kinase‐3β (GSK‐3β) (Esposito et al, 2006). Naumann et al reported the synthesis of small molecule model agents carrying terpene groups as lipophile membrane anchors (Naumann et al, 2013). These modulators contributed to decrease Aβ 42 and increase Aβ 38 production and facilitated the regulation of gamma‐ecretase function, which might be a more promising approach for the treatment of AD.…”

Section: Anti‐ad Active Ingredients In Plantsmentioning

confidence: 99%

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review

Rang

Liu

et al. 2023

Phytotherapy Research

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Alzheimer's disease (AD) is one of the major neurological disorders causing death in the elderly worldwide. As a neurodegenerative disease that is difficult to prevent and cure, the pathogenesis of AD is complex and there is no effective cure. A variety of natural products derived from plants have been reported to have promising anti‐AD activities, including flavonoids, terpenes, phenolic acids and alkaloids, which can effectively relieve the symptoms of AD in a variety of ways. This paper mainly reviews the pharmacological activity and mechanisms of natural products against AD. Although the clinical efficacy of these plants still needs to be determined by further high‐quality studies, it may also provide a basis for future researchers to study anti‐AD in depth.

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Section: Anti‐ad Active Ingredients In Plantsmentioning

confidence: 99%

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review

Rang

Liu

et al. 2023

Phytotherapy Research

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“…It can be achieved either via binding with membrane receptors or with “membrane anchor,” ie, compounds or moieties that can be inserted into the phospholipid bilayer . A number of studies have demonstrated successful use of cholesterol‐based “membrane anchors” as well as linear terpenoid moieties to facilitate endocytosis.…”

Section: Introductionmentioning

confidence: 99%

Novel type of isoprenoid membrane anchors: an investigation of binding properties with dipalmitoylphosphatidylcholine vesicles

Faizullin

Dzyurkevich

Valiullina

et al. 2016

J of Physical Organic Chem

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In this work, we present a new type of amphiphilic membrane‐anchoring agents that can be easily obtained by the Diels‐Alder reaction between terpene myrcene and N‐substituted maleimides. The interaction between the compounds and small unilamellar dipalmitoylphosphatidylcholine vesicles was investigated using infrared spectroscopy, microgravimetry, and turbidimetry. The ability of the compounds to embed in the phospholipid membrane was shown to be strongly dependent on the charge of their polar group. The insertion of the compounds studied into the lipid bilayer did not lead to disruption of the dipalmitoylphosphatidylcholine vesicles up to the highest tested drug to lipid molar ratio of 0.5 to 0.6. Low lipid solubilization ability of the compounds as well as their rigid nonplanar structure makes them an interesting alternative to the common membrane‐anchoring structural motifs.

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Amphiphilic adducts of myrcene and N-substituted maleimides as potential drug delivery agents

Dzyurkevich

Timofeeva

Faizullin

et al. 2014

Mendeleev Communications

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Membrane anchoring γ-secretase modulators with terpene-derived moieties

Cited by 5 publications

References 33 publications

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review

Novel type of isoprenoid membrane anchors: an investigation of binding properties with dipalmitoylphosphatidylcholine vesicles

Amphiphilic adducts of myrcene and N-substituted maleimides as potential drug delivery agents

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