Membrane glycolipids in stem cells

Yu, Robert K.; Suzuki, Yusuke; Yanagisawa, Makoto

doi:10.1016/j.febslet.2009.08.026

Cited by 40 publications

(39 citation statements)

References 60 publications

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“…8 33 In Fig. 9, it can be seen that the EC23 treated cells are in agreement with the results seen by 50 Heraud for the carbohydrate absorption band at ~1155 cm -1 , however, there was an increase in absorption at ~2920 cm - To test these possibilities, ATRA and EC23 treated TERA2.cl.SP12 cells were compared at all time periods, Fig. 11 (a).…”

supporting

confidence: 78%

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The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy

et al. 2013

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(2013) 'The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells di erentiation investigated using single cell infrared microspectroscopy.', Molecular bioSystems., 9 (4). pp. 677-692. Further information on publisher's website:http://dx.doi.org/10.1039/c3mb25505kPublisher's copyright statement:Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details.

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confidence: 78%

“…produces very few neurons and a large number of epithelial-like 50 cells. 14 At present, it is not entirely clear how relatively small structural changes in these types of small molecules effect the different development processes, and this is therefore an important and developing area of study.…”

Section: Introductionmentioning

confidence: 99%

The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy

et al. 2013

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“…For example, membrane rafts segregated pro-from anti-apoptotic IGF1R signaling in cancer cells stimulated by members of the tumor necrosis factor superfamily through tuning the IRS-1/AKT signaling (Remacle-Bonnet et al, 2005). Indeed, bioactive lipids have been shown to play a pivotal role in the survival/proliferation of neural and cancer stem cells (Yu et al, 2010;Bieberich, 2012).…”

Section: Conclusion and Perspectivementioning

confidence: 98%

Emerging evidence of insulin-like growth factor 2 as a memory enhancer: a unique animal model of cognitive dysfunction with impaired adult neurogenesis

Iwamoto¹,

Ouchi²

2014

Reviews in the Neurosciences

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In the current aging society, cognitive dysfunction is one of the most serious issues that should be urgently resolved. It also affects a wide range of age groups harboring neurological and psychiatric disorders, such as Alzheimer's disease and schizophrenia. Although the molecular mechanism of memory impairment still remains to be determined, neuronal loss and dysfunction has been revealed to mainly attribute to its pathology. The discovery of neural stem cells in the adult brain that are proliferating and able to generate functional neurons has given rise to the idea that neuronal loss could be rescued by manipulating endogenous neural progenitor and stem cells. To this end, we must characterize them in detail and their developmental programming must be better understood. A growing body of evidence has indicated that insulin-like peptides are involved in learning and memory and maintenance of neural progenitor and stem cells, and clinical trials of insulin as a memory enhancer have begun. In contrast to the expectation of insulin and IGF1, the roles of IGF2 in cognitive ability have been poorly understood. However, recent evidence demonstrated in rodents suggests that IGF2 may play a pivotal role in adult neurogenesis and cognitive function. Here, we would like to review the rapidly growing world of IGF2 in cognitive neuroscience and introduce the evidence that its deficit is indeed involved in the impairment of the hippocampal neurogenesis and cognitive dysfunction in the model mouse of 22q11.2 deletion syndrome, which deletes Dgcr8, a critical gene for microRNA processing.

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“…Although glycosphingolipids and signaling lipids have been studied in relation to the cell identity and functions (15)(16)(17)(18), an important group of membrane lipids, the glycerophospholipids (GPL), composing the main part of membrane lipids has received less attention. The most prominent class, phosphatidylcholine (PC), makes up approximately one half of all membrane phospholipids.…”

Section: Phospholipid Mass Spectrometry and Fatty Acid Gas Chromatogrmentioning

confidence: 99%

Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality

Kilpinen

Tigistu-Sahle

Oja

et al. 2013

Journal of Lipid Research

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This article is available online at http://www.jlr.org Supplementary key words glycerophospholipid profi le • mesenchymal stem cell • arachidonic acid • docosahexaenoic acid • lipid signaling • mass spectrometry Human mesenchymal stem/stromal cells (hMSC) are currently being studied in a number of clinical applications, for example, to improve the engraftment of hematopoietic stem cell transplant, to promote myocardial repair, and to control immunological responses in graft versus host diseases, autoimmune diseases, and solid organ transplantations ( 1-5 ). In addition to being immunologically privileged, these cells can modulate both innate and adaptive immune responses in vitro and in vivo. hMSCs have been shown to be able to inhibit T-cell proliferation, inhibit dendritic cell maturation ( 6 ), recruit regulatory T-cells ( 7,8 ), and modulate B-cell functions ( 9 ). The mechanisms by which these cells exert their immune modulatory functions are still unclear, but it is likely that both direct cell-cell contacts and the secretion of soluble factors are needed. Several cytokines, growth factors, enzymes, and lipid mediators, such as transforming growth factor ␤ 1, the

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Membrane glycolipids in stem cells

Cited by 40 publications

References 60 publications

The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy

The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy

Emerging evidence of insulin-like growth factor 2 as a memory enhancer: a unique animal model of cognitive dysfunction with impaired adult neurogenesis

Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality

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