Membrane Invaginations in Bacteria and Mitochondria: Common Features and Evolutionary Scenarios

Aréchaga, Ignacio

doi:10.1159/000346515

Cited by 27 publications

(19 citation statements)

References 90 publications

(118 reference statements)

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“…The invaginations of the CM found in cells incubated in NBW, NSW and LB ON incubations may be the result of an increase in protein content relative to the lipid membrane. A similar mechanism has previously been reported in cells that overproduce membrane proteins [38][39][40]. The low level of OPGs in the periplasm of NFW VBNC cells may weaken their osmoprotection and prevent the formation of invaginations as the CM might be more strained through increased turgor pressure.…”

Section: Discussionsupporting

confidence: 70%

Structural and proteomic changes in viable but non-culturableVibrio cholerae

Brenzinger

Aart

Wezel

et al. 2018

Preprint

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Aquatic environments are reservoirs of the human pathogen Vibrio cholerae O1, which causes the acute diarrheal disease cholera. Upon low temperature or limited nutrient availability, the cells enter a viable but non-culturable (VBNC) state. Characteristic of this state are an altered morphology, low metabolic activity and lack of growth under standard laboratory conditions. Here, for the first time, the cellular ultrastructure of V. cholerae VBNC cells raised in natural waters was investigated using electron cryo-tomography complemented by comparison of the proteomes and the peptidoglycan composition of LB overnight culture and VBNC cells. The extensive remodeling of the VBNC cells was most obvious in the passive dehiscence of the cell envelope, resulting in improper embedment of flagella and pili. Only minor changes of the peptidoglycan and osmoregulated periplasmic glucans were observed. Active changes in VBNC cells included the production of cluster I chemosensory arrays and change of abundance of cluster II array proteins. Components involved in iron acquisition and storage, peptide import and arginine biosynthesis were overrepresented in VBNC cells, while enzymes of the central carbon metabolism were found at lower levels. Finally, several pathogenicity factors of V. cholerae were less abundant in the VBNC state, potentially limiting their infectious potential.

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Section: Discussionsupporting

confidence: 70%

Structural and proteomic changes in viable but non-culturableVibrio cholerae

Brenzinger

Aart

Wezel

et al. 2018

Preprint

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“…Moreover, an increased and constant level of CL in mitochondria produced a different topology product of the non-bilayer properties of this phospholipid [54]. To support this view, recent evidence has demonstrated that liposomes containing the same composition of mitochondrial membranes are responsive to local pH gradients producing invaginations similar to those observed in the mitochondrial cristae.…”

Section: Discussionmentioning

confidence: 93%

The chimeric origin of the cardiolipin biosynthetic pathway in the Eukarya domain

Luévano‐Martínez¹

2015

Biochimica et Biophysica Acta (BBA) - Bioenergetics

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Cardiolipin (CL) and phosphatidylglycerol (PG) are the main anionic phospholipids present in the Eukarya and Bacteria domains. They participate in energy transduction by activating and stabilizing the components of the oxidative phosphorylation machinery. Experimental evidence shows that they are synthesized by two different mechanisms which indicate that both pathways evolved convergently. Former studies on the lipid composition of archaeal membranes showed the absence of CL in these organisms, consequently, restricting it to the Eukarya and Bacteria domains. Interestingly, recent studies have demonstrated that both CL and PG are present as constitutive components of membranes of the haloarchaea group. However, this scenario complicates the analysis of the evolutionary origin of this biosynthetic pathway. Here I suggest that a phospholipid biosynthetic pathway in Eukarya probably arose from a chimeric event between bacterial and archaeal enzymes during the endosymbiosis event. Phylogenetic analyses support the different evolutionary origin of the enzymes comprising this pathway in bacteria and Eukarya. Based on protein domain analyses, orthologous proteins in the Archaea domain were identified. An integrative analysis of the proteins found demonstrates that CL biosynthesis in major clades of the Eukarya domain originated by chimerism between the bacteria and archaea pathways. Moreover, primary and secondary endosymbiontic events in plants and chromoalveolata respectively, reshaped this pathway again. The implications and advantages that these new enzymatic orders conferred to the Eukarya domain are discussed.

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“…Studies suggest that mitochondria share with bacteria several similarities . Both bacteria and mitochondria can consume O 2 and produce CO 2 , express formylated peptides and bear a circular genome composed of hypomethylated CpG DNA motifs .…”

Section: Mitochondria and Inflammationmentioning

confidence: 99%

Mitochondrial damage‐associated molecular patterns in blood transfusion products

Marcoux

Boilard

2017

ISBT Science Series

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Mitochondria are organelles in charge of energy supply and the control of apoptosis. Owing to their similarities with bacteria, however, extracellular mitochondria are considered damage-associated molecular patterns (DAMPs) capable of activating the immune system and non-immune cells. Studies revealed that diverse blood products contain extracellular mitochondria, which could account for the adverse reactions that can occur in transfusion. In this review, we discuss how mitochondrial DAMPs can trigger inflammatory responses, we highlight conditions relevant to transfusion during which mitochondria have been identified outside cells, and we discuss their potential as biomarkers for the assessment of blood product quality.

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Membrane Invaginations in Bacteria and Mitochondria: Common Features and Evolutionary Scenarios

Cited by 27 publications

References 90 publications

Structural and proteomic changes in viable but non-culturableVibrio cholerae

Structural and proteomic changes in viable but non-culturableVibrio cholerae

The chimeric origin of the cardiolipin biosynthetic pathway in the Eukarya domain

Mitochondrial damage‐associated molecular patterns in blood transfusion products

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