Membrane Vesicles from the Gut Microbiota and Their Interactions with the Host

Badı́a, Josefa; Baldomà, Laura

doi:10.1007/978-3-030-36331-4_9

Cited by 4 publications

(3 citation statements)

References 119 publications

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“…In pathogens, BEVs carry virulence factors, toxins and immunomodulatory effectors that help bacteria to attack host cells and subvert the host machinery to escape the immune system (Jan, 2017 ; Kaparakis‐Liaskos & Ferrero, 2015 ; Lee et al., 2008 ). For strains that establish a symbiotic relation with the host, released BEVs serve as a mechanism for the delivery of bacterial mediators that modulate important host functions (Badia & Baldomà, 2020 ).…”

Section: Bacterial Extracellular Membrane Vesiclesmentioning

confidence: 99%

“…Several studies in gut microbiota species show the role of microbiota BEVs as modulators of epithelial barrier integrity (Badia & Baldomà, 2020 ). Concerning intestinal E. coli isolates, the probiotic EcN has been extensively studied due to its recognized immunomodulatory and anti‐inflammatory properties that positively contribute to microbiota balance (Sonnenborn, 2016 ; Sonnenborn & Schulze, 2009 ; Toloza et al., 2015 ).…”

Section: Contribution Of Microbiota Bevs To Intestinal Homeostasismentioning

confidence: 99%

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Microbiota‐derived extracellular vesicles in interkingdom communication in the gut

Díaz-Garrido

Badı́a

Baldomà

2021

J of Extracellular Vesicle

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169

112

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The intestine is fundamental in controlling human health. Intestinal epithelial and immune cells are continuously exposed to millions of microbes that greatly impact on intestinal epithelial barrier and immune function. This microbial community, known as gut microbiota, is now recognized as an important partner of the human being that actively contribute to essential functions of the intestine but also of distal organs. In the gut ecosystem, bidirectional microbiota‐host communication does not involve direct cell contacts. Both microbiota and host‐derived extracellular vesicles (EVs) are key players of such interkingdom crosstalk. There is now accumulating body of evidence that bacterial secreted vesicles mediate microbiota functions by transporting and delivering into host cells effector molecules that modulate host signalling pathways and cell processes. Consequently, vesicles released by the gut microbiota may have great influence on health and disease. Here we review current knowledge on microbiota EVs and specifically highlight their role in controlling host metabolism, intestinal barrier integrity and immune training.

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Section: Bacterial Extracellular Membrane Vesiclesmentioning

confidence: 99%

Section: Contribution Of Microbiota Bevs To Intestinal Homeostasismentioning

confidence: 99%

Microbiota‐derived extracellular vesicles in interkingdom communication in the gut

Díaz-Garrido

Badı́a

Baldomà

2021

J of Extracellular Vesicle

Self Cite

169

112

View full text Add to dashboard Cite

show abstract

“… 13–16 By contrast, MV from commensal and beneficial bacteria can influence host metabolism, 17 protect against intestinal inflammation, 18–20 and modulate intestinal barrier strength, 21 among others. 22 …”

Section: Introductionmentioning

confidence: 99%