Membranous glomerulonephritis associated with hepatitis C virus infection: case report and literature review

Uchiyama-Tanaka, Yoko; Mori, Yuki; Kishimoto, Noriko; Nose, Atsuko; Kijima, Yasuaki; Nagata, Toshiko; Umeda, Yukihisa; Masaki, Hiroya; Matsubara, Hirofumi; Iwasaka, Tsuyoshi

doi:10.5414/cnp61144

Cited by 32 publications

(9 citation statements)

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“…During pathological conditions such as viral infections, viral RNA alone or as part of immune complexes could reach the mesangium and trigger glomerular inflammation, resulting, eg, in HCV-associated glomerulonephritis. 2,21 In support of this hypothesis, we found increased mRNA levels for TLR3 and for proinflammatory cytokines and chemokines in microdissected glomeruli from biopsies of hepatitis C-associated but not idiopathic membranoproliferative glomerulonephritis and propose that TLR3 expression in MCs may play a role in some forms of glomerulonephritis.…”

supporting

confidence: 59%

Novel Role of Toll-Like Receptor 3 in Hepatitis C-Associated Glomerulonephritis

Wörnle

Schmid

Banas

et al. 2006

The American Journal of Pathology

146

113

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supporting

confidence: 59%

Novel Role of Toll-Like Receptor 3 in Hepatitis C-Associated Glomerulonephritis

Wörnle

Schmid

Banas

et al. 2006

The American Journal of Pathology

146

113

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“…Notably, membranous nephropathy in HCV carriers is characterized by the absence of cryoglobulin and male predominance. 47…”

Section: Clinical Characteristicsmentioning

confidence: 99%

Viral nephropathy

Lai

2006

Nat Rev Nephrol

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Viral infections can cause many glomerular diseases. The diagnostic criteria for virus-related nephropathy include detailed clinical and laboratory data, and tissue molecular analysis. Several mechanisms are involved in the pathogenesis of virus-related nephropathy, including tropism of the virus in the kidney, induction of abnormal immune complexes, direct cytopathogenic effects, and multiorgan failure. Hepatitis B virus is associated with membranous nephropathy and mesangiocapillary glomerulonephritis in endemic areas. Hepatitis C virus causes various forms of glomerulonephritis, including cryoglobulinemia-mediated glomerulonephritis. Infection with HIV is associated with a collapsing focal segmental glomerulosclerosis, a distinctive disease that affects mainly Africans and African Americans. In the course of HIV infection, other types of immune complex glomerulonephritis can occur, most frequently in whites. Recent reports indicate a role for parvovirus B19 in 'idiopathic' collapsing focal segmental glomerulosclerosis. Both hantaviruses, and coronaviruses associated with severe acute respiratory syndrome, can lead to acute renal failure. Renal biopsy followed by appropriate serological and molecular testing is essential for defining virus-related glomerular lesions and guiding prognostic and therapeutic evaluation.

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“…A separate Japanese study of 2 patients with membranous nephropathy demonstrated pathogenic linkage to HCV by detecting HCV core protein in the affected glomeruli using immunofluorescence (Okada et al, 1996). In contrast to HCV-associated MPGN, HCV-associated membranous nephropathy does not appear associated with cryoglobulinaemia, rheumatoid factor or hypocomplementaemia (Uchiyama-Tanaka et al, 2004). …”

Section: Immunopathogenesismentioning

confidence: 66%