Memory B And T Cells

Vitetta, Ellen S.; Berton, Michael T.; Burger, Christa; Kepron, M.R.; Lee, William T.; Yin, Xiao‐Ming

doi:10.1146/annurev.immunol.9.1.193

Cited by 31 publications

(30 citation statements)

References 69 publications

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“…Unprimed cells carry the CD45RA isoform of the CD45-receptor, while memory cells express the CD45R0 epitope (Vitetta et al, 1991). We and others (O'Leary et al, 1988;Yen et al, 2000) found no significant changes of the CD4/ CD8 ratio with aging.…”

Section: Discussioncontrasting

confidence: 41%

Age-related impairment of human T lymphocytes’ activation: specific differences between CD4+ and CD8+ subsets

Schindowski

Fröhlich

Maurer

et al. 2002

Mechanisms of Ageing and Development

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The relevance of physiological immune aging is of great interest with respect to determining disorders with pathologic immune function in aging individuals. In recent years, the relevance of changes in peripheral lymphocytes in age-associated neurologic diseases has become more evident. Due to the lack of immunological studies. covering moce than one event after mitogenic activation, we envisaged a new concept in the present study, aiming to investigate several events, starting from T cell receptor (TCR) ligation up to T cell proliferation. In addition, we addressed the question whether changes are present in the subsets (CD4, CDR) with aging. Phosphorylation of tyrosine residues declines with increasing age in CD4+ cells. Fewer levels of CD69 positive cells after 4 h mitogenic activation, altered expression of cytokines (IL2, IFN-7 and TNF-a; 22 h) and lower proliferation (72 h) were detemined in aging. Moreover, it could be shown that CD8" lymphocytes react more effectively to mitogenic stirnulation with referenoe to CD69 expression and proliferation in both age groups ( < 35 and > 60 years old). These data indicate that T cell activation, rnediated by TCR engagement, is significantly impaired in aging and both subsets are affected. However, bypassing the TCR does not fully restore T cell function, indicating that there are more mechanisms involved than impaired signal transduction thwugh TCR only. The results will be discussed in relation to iiheir relevance in neurodegenerative and psychiatric disorders.

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Section: Discussioncontrasting

confidence: 41%

Age-related impairment of human T lymphocytes’ activation: specific differences between CD4+ and CD8+ subsets

Schindowski

Fröhlich

Maurer

et al. 2002

Mechanisms of Ageing and Development

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“…In earlier reports, the expression patterns ol'CD45RA and CD45RO were analysed for the CD4* subset, and the CD45RA' subset, including both CD45RA^"' and CD45RA''""* cells, was studied [6.7,16]. We analysed the agerelated changes in CD45RA^"^ and CD45RA*"'"^ T cells separately, since the function of CLMSRA**""^ T cells was suggested to be distinct from that of CD45RA''"^ T cells [20][21][22][23], and this subset co-expresses CD45RO at a low level. In addition, the expression patterns of CD45RA and CD45RO were analysed not only for the CD4^ subset but also for the CD8^ subset, CD45RA''"' CD3^ lymphocytes decreased with age, as expected on the basis of previous observation [3,6,7], while no age-related changes in CD45RA*'""^ T cells were detected.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in surface antigens on peripheral lymphocytes of healthy children

Osugi

Hara

Kurahashi

et al. 1995

Clinical and Experimental Immunology

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“…form CD45RO, these molecules have been proposed as markers for naive (CD45RA ϩ /RO Ϫ ) and memory (CD45RA Ϫ / RO ϩ ) T cells (17,18). The following well-established observations corroborate this notion: 1) CD45RO ϩ cells are reduced under conditions of limited antigenic exposure, such as in human cord blood or in neonatal mice; 2) CD45RO ϩ cells are almost absent in the spleens of mice bred in a germfree environment; 3) increased proportions of CD45RO ϩ T cells are found in the peripheral blood of aging or immunized humans and animals; and 4) CD4 ϩ CD45RO ϩ T cells predominantly give rise to the human response to recall Ags such as tetanus toxoid (TT) in immunized subjects (19). More recent data, however, demonstrated that changes in CD45R isoforms are reversible in the rat (20,21).…”

mentioning

confidence: 99%

Human Autoreactive CD4+ T Cells from Naive CD45RA+ and Memory CD45RO+ Subsets Differ with Respect to Epitope Specificity and Functional Antigen Avidity

Muraro

Pette

Bielekova

et al. 2000

The Journal of Immunology

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T cells with specificity for self-Ags are normally present in the peripheral blood, and, upon activation, may target tissue Ags and become involved in the pathogenesis of autoimmune processes. In multiple sclerosis, a demyelinating disease of the CNS, it is postulated that inflammatory damage is initiated by CD4+ T cells reactive to myelin Ags. To investigate the potential naive vs memory origin of circulating myelin-reactive cells, we have generated myelin basic protein (MBP)- and tetanus toxoid-specific T cell clones from CD45RA+/RO− and CD45RO+/RA− CD4+ T cell subsets from the peripheral blood of multiple sclerosis patients and controls. Our results show that 1) the response to MBP, different from that to TT, predominantly emerges from the CD45RA+ subset; 2) the reactivity to immunodominant MBP epitopes mostly resides in the CD45RA+ subset; 3) in each individual, the recognition of single MBP epitopes is skewed to either subset, with no overlap in the Ag fine specificity; and 4) in spite of a lower expression of costimulatory and adhesion molecules, CD45RA+ subset-derived clones recognize epitopes with higher functional Ag avidity. These findings point to a central role of the naive CD45RA+ T cell subset as the source for immunodominant, potentially pathogenic effector CD4+ T cell responses in humans.

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Memory B And T Cells

Cited by 31 publications

References 69 publications

Age-related impairment of human T lymphocytes’ activation: specific differences between CD4+ and CD8+ subsets

Age-related impairment of human T lymphocytes’ activation: specific differences between CD4+ and CD8+ subsets

Age-related changes in surface antigens on peripheral lymphocytes of healthy children

Human Autoreactive CD4+ T Cells from Naive CD45RA+ and Memory CD45RO+ Subsets Differ with Respect to Epitope Specificity and Functional Antigen Avidity

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