Memory Clinics and Day Care Centers in Thessaloniki, Northern Greece: 30 Years of Clinical Practice and Experience

Tsolaki, Magda; Tsatali, Marianna; Γκιόκα, Μάρα; Poptsi, Eleni; Tsolaki, Anthoula; Papaliagkas, Vasileios; Tabakis, Irene-Maria; Lazarou, Ioulietta; Makri, Marina; Kazis, Dimitrios; Papagiannopoulos, Sotirios; Kiryttopoulos, Andreas; Koutsouraki, Efrosyni; Tegos, Thomas

doi:10.3389/fneur.2021.683131

Cited by 3 publications

(1 citation statement)

References 95 publications

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“…However, the differences between the Greek sample and the others may result from unique sample characteristics. The majority of the Greek participants were recruited through the Panhellenic Federation of Alzheimer's Disease and Related Disorders, which has actively provided various services, including awareness campaigns and educational events for the general public and families dealing with AD (Karagiozi et al, 2017;Tsolaki et al, 2021). Consequently, a significant number of Greek families were aware of screening programs.…”

Section: Statistical Group-comparisonsmentioning

confidence: 99%

Attitudes toward pre-symptomatic screening for Alzheimer’s dementia in five European countries: a comparison of family members of people with Alzheimer’s dementia versus non-family members

Angelidou,

Makri,

Beyreuther

et al. 2023

Front. Genet.

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Introduction: Pre-symptomatic screening is getting more attention in healthcare as it detects the risk for developing neurodegenerative diseases like Alzheimer’s disease (AD), which is very useful for treatment or prevention. AD screening could play an important role in individuals with at least one affected first-degree relative, but also without family history. As the demand for screening is rising worldwide, it is important to consider possible cross-cultural differences in attitudes toward pre-symptomatic screening in order to tailor healthcare services to the needs of each country.Objective: This study aims to investigate the attitudes of family members and non-family members of people with dementia toward pre-symptomatic screening and explore possible differences in attitudes across five European countries (Belgium, Germany, Greece, Spain, Turkey) using translated versions of the “Perceptions regarding pRE-symptomatic Alzheimer’s Disease Screening” questionnaire (PRE-ADS).Methods: The multicultural sample (N = 650) was recruited from samples that were previously used in validation studies of the translated PRE-ADS versions. The subscale “Acceptability of Screening”, consisting of five PRE-ADS items to specifically explore willingness to undergo screening, was created. Ιnternal consistency was measured, and structural validity was determined using Confirmatory Factor Analysis (CFA). Group comparisons were performed to investigate differences in attitudes toward pre-symptomatic AD screening regarding family history and country of origin using the PRE-ADS and the “Acceptability of Screening” mean scores.Results: Construct validity was acceptable for the PRE-ADS. Both the PRE-ADS (α = 0.76) and its subscale “Acceptability of Screening” (α = 0.90) had good internal consistency. Overall, 56.9% of the total sample expressed a positive intention toward pre-symptomatic AD screening. T-tests showed significantly higher mean scores of participants with an affected family member. An international comparison revealed differences in the “Acceptability of Screening” mean score across the five European countries. No cross-cultural differences were found for the PRE-ADS mean score after adjusting for confounding variables.Conclusion: The PRE-ADS and its subscale are reliable tools for assessing pre-symptomatic AD screening attitudes. Variations in the acceptability of screening seem to be linked to family history and cultural influences. Further research with larger samples is needed to explore underlying relationships.

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Section: Statistical Group-comparisonsmentioning

confidence: 99%

Attitudes toward pre-symptomatic screening for Alzheimer’s dementia in five European countries: a comparison of family members of people with Alzheimer’s dementia versus non-family members

Angelidou,

Makri,

Beyreuther

et al. 2023

Front. Genet.

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Language Markers of Dementia and Their Role in Early Diagnosis of Alzheimer’s Disease: Exploring Grammatical and Syntactic Competence via Sentence Repetition

Kaltsa,

Tsolaki,

Lazarou

et al. 2024

Journal of Alzheimer's Disease Reports

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Background: Earlier research focuses primarily on the cognitive changes due to Alzheimer’s disease (AD); however, little is known with regard to changes in language competence across the lifespan. Objective: The present study aims to investigate the decline of language skills at the grammatical and syntactic levels due to changes in cognitive function. Methods: We administered the Litmus Sentence Repetition Task (SRT) to 150 native speakers of Greek who fall into five groups: 1) young healthy speakers, 2) cognitively intact elder healthy speakers, 3) speakers with subjective cognitive impairment (SCI), 4) speakers with mild cognitive impairment (MCI); and 5) speakers with AD dementia at the mild/moderate stages. All participants underwent a physical and neurological examination and cognitive screening with a standardized neuropsychological battery to assess cognitive status comprehensively and evaluate aspects like working memory, executive function, attention and memory to appropriately classify them. Results: The data analysis revealed that the SRT had high discriminatory value in the development of AD; specifically, both accuracy and grammaticality indices were related to cognitive decline. Additionally, syntax significantly affected the performance of speakers with structures such as clitics being particularly challenging and in most structures the performance of speakers with MCI drops significantly compared to speakers with SCI. Conclusions: Linguistic indices revealed subtle early signs of cognitive decline that can be helpful in the early detection of AD, thus facilitating the clinical process offering support to language-based assessment tools such as sentence repetition, a non-invasive type of assessment to evaluate symptoms of AD.

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Assessing the Linguistic Capacity Across Alzheimer’s Disease and Its Preclinical Stages: Evidence from Narrative Macrostructure in Elderly Speakers of Greek

Kaltsa,

Tsolaki,

Lazarou

et al. 2024

JAD

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Background: The assessment of language deficits can be valuable in the early clinical diagnosis of neurodegenerative disorders, including Alzheimer’s disease (AD). Objective: The present study aims to explore whether language markers at the macrostructural level could assist with the placement of an individual across the dementia continuum employing production data from structured narratives. Methods: We administered a Picture Sequence Narrative Discourse Task to 170 speakers of Greek: young healthy controls (yHC), cognitively intact healthy elders (eHC), elder participants with subjective cognitive impairment (SCI), with mild cognitive impairment (MCI), and with AD dementia at the mild/moderate stages. Structural MRIs, medical history, neurological examination, and neuropsychological/cognitive screening determined the status of each speaker to appropriately groupthem. Results: The data analysis revealed that the Macrostructure Index, Irrelevant Info, and Narration Density markers can track cognitive decline and AD (p < 0.001; Macrostructural Index: eHC versus AD Sensitivity 93.8%, Specificity 74.4%, MCI versus AD Sensitivity 93.8%, Specificity 66.7%; Narration Density: eHC versus AD Sensitivity 90.6%, Specificity 71.8%, MCI versus AD Sensitivity 93.8%, Specificity 66.7%). Moreover, Narrative Complexity was significantly affected for subjects with AD, Irrelevant Info increased in the narrations of speakers with MCI and AD, while Narration Length did not appear to indubitably differentiate between the cognitively intact groups and the clinical ones. Conclusions: Narrative Macrostructure Indices provide valuable information on the language profile of speakers with(out) intact cognition revealing subtle early signs of cognitive decline and AD suggesting that the inclusion of language-based assessment tools would facilitate the clinical process.

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Memory Clinics and Day Care Centers in Thessaloniki, Northern Greece: 30 Years of Clinical Practice and Experience

Cited by 3 publications

References 95 publications

Attitudes toward pre-symptomatic screening for Alzheimer’s dementia in five European countries: a comparison of family members of people with Alzheimer’s dementia versus non-family members

Attitudes toward pre-symptomatic screening for Alzheimer’s dementia in five European countries: a comparison of family members of people with Alzheimer’s dementia versus non-family members

Language Markers of Dementia and Their Role in Early Diagnosis of Alzheimer’s Disease: Exploring Grammatical and Syntactic Competence via Sentence Repetition

Assessing the Linguistic Capacity Across Alzheimer’s Disease and Its Preclinical Stages: Evidence from Narrative Macrostructure in Elderly Speakers of Greek

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