The complex nature of many neurodegenerative disorders warrants the need for multi-component interventions. These disorders, like Alzheimer's disease and Parkinson's disease, are typically characterized by a broad range of symptoms. Because of this, these disorders pose a significant challenge to medical specialists, not only for adequate diagnosis but also for the management of the wide array of symptoms. An additional difficulty is the fact that the clinical presentation is highly variable across individuals, in terms of disease manifestation and progression, as well as the individual perception of most troublesome problems [1]. This great inter-individual variation creates an even greater challenge to optimize treatment tailored to each individual patient's needs and priorities. Due to this complexity, treatment by health care professionals from multiple complementary disciplines seems warranted. Here, some examples will be described to illustrate the complexity of designing en evaluating these multidisciplinary team approaches.
Parkinson's Disease: A Multidimensional DisorderAn example of a complex disorder is Parkinson's disease. Although, typically known for its motor features, a range of non-motor symptoms are increasingly recognized as a substantial part of Parkinson's disease [2]. These non-motor features (including gastrointestinal, mood, attention and sleep problems) have a negative impact on quality of life, in fact, even greater than motor symptoms [3]. Therefore, multidisciplinary treatment seems preferable over a single-clinician approach to satisfactorily manage this broad disorder. Indeed, guidelines for Parkinson's disease recommend that patients should have access to several health care professionals [4,5]. Yet, these guidelines do not provide an evidence-based template on how to best organize such care.
No Standard TemplateThere is no standard available on how to best organize these approaches, in terms of which specialist should be involved or the optimal way to implement team approaches into everyday healthcare settings [6]. Subsequently, many Parkinson centers worldwide offer team-based care, but their approaches vary widely regarding the disciplines and number of specialists involved, and the type of collaboration between these team members [6,7]. In addition, the implementation of team approaches within current health care systems vary; some centers offer their team approaches as inpatient services (e.g. to fine-tune therapeutic effects of medications during intensive treatment), while others have implemented outpatient services [7]. These outpatient services might be located in one single center where both diagnostics and treatment are provided by the same team [8]. Alternatively, care might be provided as an integrated approach of complementary elements. For example, as a Dutch model of Parkinson care that has been put to the test recently [9]. Here, patients are referred to a tertiary referral center for an individually tailored multidisciplinary assessment. After integration of treat...