Memory Enhancing Effect of Black Pepper in the AlCl3 Induced Neurotoxicity Mouse Model is Mediated Through Its Active Component Chavicine

Iqbal, Ghazala; Iqbal, Anila; Mahboob, Aamra; Farhat, Syeda Mehpara; Ahmed, Touqeer

doi:10.2174/1389201017666160709202124

Cited by 25 publications

(17 citation statements)

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“…It was originally designed to test the ability of rats to learn and remember the position of a hidden platform in an opaque water pool relative to external cues. In agreement with Thenmozhi et al (2015) and Iqbal et al (2016), our results suggest that AlCl3-intoxicated rats took longer to reach the platform compared to control rats during the acquisition phase, and during the probe the intoxicated rats have a significantly lower latency in the NO frame compared to control rats (Fig 4,5 and 6). Experiments have shown that the use of AlCl3 leads to a decrease in learning and memory capacity and to a dysfunction of cholinergic neurons.…”

Section: Morris Pool Testsupporting

confidence: 88%

Prophylactic Effect of A Probiotic Strain Lactobacillus Rhamnosus Against Aluminum Chloride-Induced Intoxication in Wistar Rats: Neurobehavioral and Hematobiochemical Studies

Adli¹,

Benreguieg²,

Ziani³

et al. 2022

AGJSR

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Purpose: Aluminum (Al) and its various forms are environmental xenobiotics that pose great threats to public health. The probiotic strain has been reported to have important protective effects against aluminum cytotoxicity. Therefore, the current study was designed to assess the disruption of neurobehavioral and hematobiochemical parameters caused by chronic exposure to AlCl3, and then explore the protective effects of the probiotic strain Lactobacillus rhamnosus against these adverse in male rats. Method: Thirty-two animals were gathered into four groups: The first group served as control. The second group received 100mg AlCl3/kg bw for 12 weeks. However, the third group was administered 10mL probiotic strain /Kg (108 CFU/ml) bw/d daily for 4 weeks. Finally, group 4 received AlCl3 for 12 weeks, then the treatment was continued with probiotic for 4 weeks. Results: AlCl3 produced a decrease in body and brain weights with respect to their control. The results obtained also showed significant depression and anxiety-like behavior in the intoxicated animals, with a disturbance of the tested hematobiochemical parameters, particularly in renal and hepatic biomarkers. Overall, probiotics prevented enduring AlCl3-induced depression-like behavior in intoxicated rats. The results of the hematobiochemical, renal and hepatic analyses show a correction of the values after the administration of probiotics compared to those of intoxicated and untreated animals. Conclusion: The probiotic lactobacilli would be an alternative to reduce AlCl3 toxicity.

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Section: Morris Pool Testsupporting

confidence: 88%

Prophylactic Effect of A Probiotic Strain Lactobacillus Rhamnosus Against Aluminum Chloride-Induced Intoxication in Wistar Rats: Neurobehavioral and Hematobiochemical Studies

Adli¹,

Benreguieg²,

Ziani³

et al. 2022

AGJSR

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“…Plants with large amounts of biologically active compounds could be used for the prevention and treatment of neurological disorders such as AD ( 18 19 ). Several studies have shown the beneficial effects of separate administration of PN and CZ extracts in different models of memory impairment ( 6 7 11 12 ). However, no one before has looked at the effect of co-administration of these extracts on memory performance.…”

Section: Discussionmentioning

confidence: 99%

“…We used an eight-day treatment here, while other studies have extended this period to as many as four weeks. ( 6 33 ). One reason for not extending the period of treatment with pepper is the irritating action of this plant.…”

Section: Discussionmentioning

confidence: 99%

“…The main component of this plant is piperine, the amount of which in the plant is between 5-10% ( 5 ). Piperine and its isomer called chavicine have been significantly reduced the expression of amyloid-producing isoforms in the cerebral cortex, hippocampus, and amygdala ( 6 ). Previous studies have claimed that P. nigrum can inhibit acetylcholinesterase and butyrylcholinesterase enzymes by as much as 55% and 90%, respectively ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Piper nigrum fruit and Cinnamum zeylanicum bark alcoholic extracts, alone and in combination, on scopolamine-induced memory impairment in mice

Teymuori

Yegdaneh

Rabbani

2021

Research in Pharmaceutical Sciences

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Background and purpose: Alzheimer’s disease is a progressive brain disorder that is thought to be triggered via disruption of cholinergic neurons and enhanced oxidative stress. Therefore, antioxidant phytochemicals with the ability to fortify cholinergic function should help in preventing the progress of the disease. This study aimed at evaluating the combinational effects of two popular herbs one with anticholinesterase activity namely Piper nigrum and the other with antioxidant capacity, Cinnamomum zeylanicum . Experimental approach: In this study, P. nigrum extract (PN) (50, 100 mg/kg, ip) and C. zeylanicum extract (CZ) (100, 200, 400 mg/kg, ip) and their combinations were administered for 8 days before the injection of scopolamine (1 mg/kg, ip). Mice were then tested for their memory using two behavioral models, namely the object recognition test and the passive avoidance task. Findings/Results: Administration of scopolamine significantly impaired memory performance in both memory paradigms. In the passive avoidance test (PAT) model, PN at doses up to 100 mg/kg and CZ at doses up to 400 mg/kg did not significantly alter the memory impairment induced by scopolamine. The combination of these two plant extracts did not change the PAT parameters. In the object recognition test (ORT) model, however, administration of 100 mg/kg CZ alone and a combination of PN (50 mg/kg) with CZ (400 mg/kg), significantly increased the recognition index ( P < 0.05). Conclusion and implications: Two plant extracts when administered alone or in combinations affected the memory performance differently in two memory paradigms. In the PAT model, the extracts did not show any memory improvement, in ORT, however, some improvements were observed after plant extracts.

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“…Thus, the inhibition Alkaloids are the main class produced by the shikimic acid pathway present in black pepper, especially the piperamides [94]. These metabolites are present in the fruits and seeds of black pepper, and have wide pharmacological applicability, such as in antimetastatic, antidepressant, hepatoprotective and antitumor activities, and they also have neuroprotective effects [95,96]. Alkaloid concentrations and their biological properties are directly related to PAL activity in the plant [97,98].…”

Section: Homology Modeling and Molecular Docking To Fusariummentioning

confidence: 99%

Secondary Metabolic Profile as a Tool for Distinction and Characterization of Cultivars of Black Pepper (Piper nigrum L.) Cultivated in Pará State, Brazil

Barata

Andrade

Ramos

et al. 2021

IJMS

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This study evaluated the chemical compositions of the leaves and fruits of eight black pepper cultivars cultivated in Pará State (Amazon, Brazil). Hydrodistillation and gas chromatography–mass spectrometry were employed to extract and analyze the volatile compounds, respectively. Sesquiterpene hydrocarbons were predominant (58.5–90.9%) in the cultivars “Cingapura”, “Equador”, “Guajarina”, “Iaçará”, and “Kottanadan”, and “Bragantina”, “Clonada”, and “Uthirankota” displayed oxygenated sesquiterpenoids (50.6–75.0%). The multivariate statistical analysis applied using volatile composition grouped the samples into four groups: γ-Elemene, curzerene, and δ-elemene (“Equador”/“Guajarina”, I); δ-elemene (“Iaçará”/“Kottanadan”/“Cingapura”, II); elemol (“Clonada”/“Uthirankota”, III) and α-muurolol, bicyclogermacrene, and cubebol (“Bragantina”, IV). The major compounds in all fruit samples were monoterpene hydrocarbons such as α-pinene, β-pinene, and limonene. Among the cultivar leaves, phenolics content (44.75–140.53 mg GAE·g−1 FW), the enzymatic activity of phenylalanine-ammonia lyase (20.19–57.22 µU·mL−1), and carotenoids (0.21–2.31 µg·mL−1) displayed significant variations. Due to black pepper’s susceptibility to Fusarium infection, a molecular docking analysis was carried out on Fusarium protein targets using each cultivar’s volatile components. F. oxysporum endoglucanase was identified as the preferential protein target of the compounds. These results can be used to identify chemical markers related to the susceptibility degree of black pepper cultivars to plant diseases prevalent in Pará State.

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Memory Enhancing Effect of Black Pepper in the AlCl3 Induced Neurotoxicity Mouse Model is Mediated Through Its Active Component Chavicine

Abstract: The study revealed that BP improves memory and chavicine is a lead compound producing pharmacological effects of BP.

Cited by 25 publications

References 0 publications

Prophylactic Effect of A Probiotic Strain Lactobacillus Rhamnosus Against Aluminum Chloride-Induced Intoxication in Wistar Rats: Neurobehavioral and Hematobiochemical Studies

Prophylactic Effect of A Probiotic Strain Lactobacillus Rhamnosus Against Aluminum Chloride-Induced Intoxication in Wistar Rats: Neurobehavioral and Hematobiochemical Studies

Effects of Piper nigrum fruit and Cinnamum zeylanicum bark alcoholic extracts, alone and in combination, on scopolamine-induced memory impairment in mice

Secondary Metabolic Profile as a Tool for Distinction and Characterization of Cultivars of Black Pepper (Piper nigrum L.) Cultivated in Pará State, Brazil

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