Memory for Pain? A Comparison of Nonexperiential Estimates and Patients’ Reports of the Quality and Intensity of Postoperative Pain

Terry, Rohini; Niven, Catherine A.; Brodie, Eric E.; Jones, Ray; Prowse, Morag

doi:10.1016/j.jpain.2007.11.008

Cited by 18 publications

(16 citation statements)

References 24 publications

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“…Studying pain by questionnaires, especially when retrospective, is challenging. The memory of pain is subjective and depends on actual circumstances, as it may vary according to the actual state of mind or environmental issues …”

Section: Discussionmentioning

confidence: 99%

Postoperative hyperalgesia does not predict persistent post‐sternotomy pain; observational study based on clinical examination

Setälä

Kalliomäki

Järvelä

et al. 2015

Acta Anaesthesiol Scand

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Section: Discussionmentioning

confidence: 99%

Postoperative hyperalgesia does not predict persistent post‐sternotomy pain; observational study based on clinical examination

Setälä

Kalliomäki

Järvelä

et al. 2015

Acta Anaesthesiol Scand

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“…Persistent pain caused by inflammation, surgical wounds, and other injuries is a very common phenomenon. Patients who suffer from nociceptive pain for a long time may feel persistent pain even after recovery of the initial cause of pain [ 1 , 2 ]. Animal studies also reported that nociceptive hyperalgesia could recur far away from the primary injured region after repeated carrageen-induced inflammation [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture alleviates retrieval of pain memory and its effect on phosphorylation of cAMP response element-binding protein in anterior cingulate cortex in rats

et al. 2015

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BackgroundRecent evidence suggests that persistent pain and recurrent pain are due to the pain memory which is related to the phosphorylation of cAMP response element-binding protein (p-CREB) in anterior cingulate cortex (ACC). Eletroacupuncture (EA), as a complementary Chinese medical procedure, has a significant impact on the treatment of pain and is now considered as a mind-body therapy.MethodsThe rat model of pain memory was induced by two injections of carrageenan into the paws, which was administered separately by a 14-day interval, and treated with EA therapy. The paw withdrawal thresholds (PWTs) of animals were measured and p-CREB expressions in ACC were detected by using immunofluorescence (IF) and electrophoretic mobility shift assay (EMSA). Statistical comparisons among different groups were made by one-way, repeated-measures analysis of variance (ANOVA).ResultsThe second injection of carrageenan caused the decrease of PWTs in the non-injected hind paw. EA stimulation applied prior to the second injection, increased the values of PWTs. In ACC, the numbers of p-CREB positive cells were significantly increased in pain memory model rats, which were significantly reduced by EA. EMSA results showed EA also down-regulated the combining capacity of p-CREB with its DNA. Furthermore, the co-expression of p-CREB with GFAP, OX-42, or NeuN in ACC was strengthened in the pain memory model rats. EA inhibited the co-expression of p-CREB with GFAP or OX-42, but not NeuN in ACC.ConclusionsThe present results suggest the retrieval of pain memory could be alleviated by the pre-treatment of EA, which is at least partially attributed to the down-regulated expression and combining capacity of p-CREB and the decreased expression of p-CREB in astrocytes and microglia cells.

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“…In clinic, physicians have found that pain memory is accompanied by complex regional pain syndrome [6], phantom pain [30], postoperative pain [31], and long histories of chronic pain [32]. To explore the effective therapy and the potential mechanisms of pain memory, affective-motivational and evaluative-cognitive pain have increasingly gained researchers' attentions [2, 3, 26, 28, 33].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model

et al. 2016

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Pain memory is considered as endopathic factor underlying stubborn chronic pain. Our previous study demonstrated that electroacupuncture (EA) can alleviate retrieval of pain memory. This study was designed to observe the different effects between EA and indomethacin (a kind of nonsteroid anti-inflammatory drugs, NSAIDs) in a rat pain memory model. To explore the critical role of protein kinase A (PKA) in pain memory, a PKA inhibitor was microinjected into anterior cingulate cortex (ACC) in model rats. We further investigated the roles of the cyclic adenosine monophosphate (cAMP), PKA, cAMP response element-binding protein (CREB), and cAMP/PKA/CREB pathway in pain memory to explore the potential molecular mechanism. The results showed that EA alleviates the retrieval of pain memory while indomethacin failed. Intra-ACC microinjection of a PKA inhibitor blocked the occurrence of pain memory. EA reduced the activation of cAMP, PKA, and CREB and the coexpression levels of cAMP/PKA and PKA/CREB in the ACC of pain memory model rats, but indomethacin failed. The present findings identified a critical role of PKA in ACC in retrieval of pain memory. We propose that the proper mechanism of EA on pain memory is possibly due to the partial inhibition of cAMP/PKA/CREB signaling pathway by EA.

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Memory for Pain? A Comparison of Nonexperiential Estimates and Patients’ Reports of the Quality and Intensity of Postoperative Pain

Cited by 18 publications

References 24 publications

Postoperative hyperalgesia does not predict persistent post‐sternotomy pain; observational study based on clinical examination

Postoperative hyperalgesia does not predict persistent post‐sternotomy pain; observational study based on clinical examination

Electroacupuncture alleviates retrieval of pain memory and its effect on phosphorylation of cAMP response element-binding protein in anterior cingulate cortex in rats

Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model

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