Memory functions and temporal-limbic morphology in schizophrenia

COLOMBO, C; Abbruzzese, Massimo; Livian, Simin; Locatelli, Marco; Bonfanti, Angelica; Scarone, Silvio

doi:10.1016/0165-1781(93)80006-q

Cited by 8 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We call particular attention to the white matter fiber tracts of the corpus callosum, because we think they strongly illustrate the power of this technique in visualizing heretofore unseen fiber tracts in vivo. Summary of MR studies seporting positive and negative findings in schizophenia (Table is updated Gur et al, 1994Gur et al, , 1998bGur et al, , 1999Jernigan et al, 1991;Nasrallah et al, 1990;Rajarethinam et al, 2000;Sanfilipo et al, 2000a;Whitworth et al, 1998] − Bilder et al, 1994;Blackwood et al, 1991;Breier et al, 1992;Buchanan et al, 1993Buchanan et al, , 1998Cannon et al, 1998;Colombo et al, 1993;Dauphinais et al, 1990Flaum et al, 1995;Goldstein et al, 1999;Harvey et al, 1993;Hazlett et al, 1999;Hirayasu et al, 1998Hirayasu et al, , 2000…”

Section: Summary Of Mri Findings and Future Directions For Researchmentioning

confidence: 99%

“…[ Colombo et al, 1993;Deicken et al, 1999;DeLisi et al, 1991;Harvey et al, 1993;Havermans et al, 1999;Marsh et al, 1997;Marsh et al, 1999;Niemann et al, 2000;Sanfilipo et al, 2000b;Staal et al, 2000;Swayze et al, 1992;Zipursky et al, 1994] STG GM 100 0 12 0 12 + [Gur et al, 2000a;Hajek et al, 1997;Hirayasu et al, 1998;Holinger et al, 1999;Keshavan et al, 1998b;Marsh et al, 1999;Menon et al, 1995;Sanfilipo et al, 2000b;Schlaepfer et al, 1994;Shenton et al, 1992;Sullivan et al, 1998;…”

mentioning

confidence: 99%

See 1 more Smart Citation

A review of MRI findings in schizophrenia

Shenton

Dickey

Frumin

et al. 2001

Schizophrenia Research

2,146

121

1,332

View full text Add to dashboard Cite

After more than 100 years of research, the neuropathology of schizophrenia remains unknown and this is despite the fact that both Kraepelin (1919/1971: Kraepelin,E., 1919/1971. Dementia praecox. Churchill Livingston Inc., New York) and Bleuler (1911/1950: Bleuler, E., 1911/1950. Dementia praecox or the group of schizophrenias. International Universities Press, New York), who first described 'dementia praecox' and the ' schizophrenias', were convinced that schizophrenia would ultimately be linked to an organic brain disorder. Alzheimer (1897: Alzheimer, A., 1897. Beitrage zur pathologischen anatomie der hirnrinde und zur anatomischen grundlage einiger psychosen. Monatsschrift fur Psychiarie und Neurologie. 2, 82-120) was the first to investigate the neuropathology of schizophrenia, though he went on to study more tractable brain diseases. The results of subsequent neuropathological studies were disappointing because of conflicting findings. Research interest thus waned and did not flourish again until 1976, following the pivotal computer assisted tomography (CT) finding of lateral ventricular enlargement in schizophrenia by Johnstone and colleagues. Since that time significant progress has been made in brain imaging, particularly with the advent of magnetic resonance imaging (MRI), beginning with the first MRI study of schizophrenia by Smith and coworkers in 1984 (Smith, R.C., Calderon, M., Ravichandran, G. K., et al. (1984). Nuclear magnetic resonance in schizophrenia: A preliminary study. Psychiatry Res. 12, 137-147). MR in vivo imaging of the brain now confirms brain abnormalities in schizophrenia.The 193 peer reviewed MRI studies reported in the current review span the period from 1988 to August, 2000. This 12 year period has witnessed a burgeoning of MRI studies and has led to more definitive findings of brain abnormalities in schizophrenia than any other time period in the history of schizophrenia research. Such progress in defining the neuropathology of schizophrenia is largely due to advances in in vivo MRI techniques. These advances have now led to the identification of a number of brain abnormalities in schizophrenia. Some of these abnormalities confirm earlier postmortem findings, and most are small and subtle, rather than large, thus necessitating more advanced and accurate measurement tools. These findings include ventricular enlargement (80% of studies reviewed) and third ventricle enlargement (73% of studies reviewed). There is also preferential involvement of medial temporal lobe structures (74% of studies reviewed), which include the amygdala, hippocampus, and parahippocampal gyrus, and neocortical temporal lobe regions (superior temporal gyrus) (100% of studies reviewed). When gray and white matter of superior temporal gyrus was combined, 67% of studies reported abnormalities. There was also moderate evidence for frontal lobe abnormalities (59% of studies reviewed), particularly prefrontal gray matter and orbitofrontal regions. Similarly, there was moderate evidence for parietal lobe ab...

show abstract

Section: Summary Of Mri Findings and Future Directions For Researchmentioning

confidence: 99%

mentioning

confidence: 99%

A review of MRI findings in schizophrenia

Shenton

Dickey

Frumin

et al. 2001

Schizophrenia Research

2,146

121

1,332

View full text Add to dashboard Cite

show abstract

“…Others have failed to find any evidence of smaller hippocampi in patients with schizophrenia, compared to controls. 52,[259][260][261][262][263][264][265][266][267][268][269][270] Meta analysis of hippocampal volumetric studies in schizophrenia concluded that schizophrenia was associated with bilateral hippocampal volume loss. 271 Lately new techniques, such as hippocampal shape analysis in schizophrenia patients are providing some interesting results.…”

Section: Schizophreniamentioning

confidence: 99%

MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders

2004

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) has opened a new window to the brain. Measuring hippocampal volume with MRI has provided important information about several neuropsychiatric disorders. We reviewed the literature and selected all English-language, human subject, data-driven papers on hippocampal volumetry, yielding a database of 423 records. Smaller hippocampal volumes have been reported in epilepsy, Alzheimer's disease, dementia, mild cognitive impairment, the aged, traumatic brain injury, cardiac arrest, Parkinson's disease, Huntington's disease, Cushing's disease, herpes simplex encephalitis, Turner's syndrome, Down's syndrome, survivors of low birth weight, schizophrenia, major depression, posttraumatic stress disorder, chronic alcoholism, borderline personality disorder, obsessive-compulsive disorder, and antisocial personality disorder. Significantly larger hippocampal volumes have been correlated with autism and children with fragile X syndrome. Preservation of hippocampal volume has been reported in congenital hyperplasia, children with fetal alcohol syndrome, anorexia nervosa, attention-deficit and hyperactivity disorder, bipolar disorder, and panic disorder. Possible mechanisms of hippocampal volume loss in neuropsychiatric disorders are discussed.

show abstract

“…For example, smaller bilateral hippocampi in patients with schizophrenia have been found by a large number of research groups, [22][23][24][25][26][27] but not by others. [28][29][30][31] Similarly, several groups found smaller bilateral hippocampi in patients with PTSD, 32,33 whereas others were unable to find significantly smaller hippocampi in PTSD. [34][35][36] In MD, significantly smaller bilateral hippocampal volumes have been reported by some, 11,37,38 but not by others.…”

mentioning

confidence: 99%

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

2004

View full text Add to dashboard Cite

The advance of neuroimaging techniques has resulted in a burgeoning of studies reporting abnormalities in brain structure and function in a number of neuropsychiatric disorders. Measurement of hippocampal volume has developed as a useful tool in the study of neuropsychiatric disorders. We reviewed the literature and selected all English-language, human subject, data-driven papers on hippocampal volumetry, yielding a database of 423 records. From this database, the methodology of all original manual tracing protocols were studied. These protocols differed in a number of important factors for accurate hippocampal volume determination including magnetic field strength, the number of slices assessed and the thickness of slices, hippocampal orientation correction, volumetric correction, software used, inter-rater reliability, and anatomical boundaries of the hippocampus. The findings are discussed in relation to optimizing determination of hippocampal volume.

show abstract

Memory functions and temporal-limbic morphology in schizophrenia

Cited by 8 publications

References 0 publications

A review of MRI findings in schizophrenia

A review of MRI findings in schizophrenia

MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

Contact Info

Product

Resources

About