Memristive Biosensors for PSA-IgM Detection

Tzouvadaki, Ioulia; Parrozzani, Chiara; Gallotta, Andrea; Micheli, Giovanni De; Carrara, Sandro

doi:10.1007/s12668-015-0179-4

Cited by 15 publications

(10 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carrara et al have been working for a while on the fabrication of memristors with silicon nanowires [84] and their further implementation for biosensing purposes [85,86]. A combination of the Complementary Metal Oxide Semiconductor (CMOS) processing technique and photolithography was used to develop poly-crystalline silicon nanowires that exhibited memristive behaviour.…”

Section: Utilisation Of Silicon For Biomedical Applicationsmentioning

confidence: 99%

Silicon-Based Sensors for Biomedical Applications: A Review

Kundu

et al. 2019

Sensors

111

View full text Add to dashboard Cite

The paper highlights some of the significant works done in the field of medical and biomedical sensing using silicon-based technology. The use of silicon sensors is one of the pivotal and prolonged techniques employed in a range of healthcare, industrial and environmental applications by virtue of its distinct advantages over other counterparts in Microelectromechanical systems (MEMS) technology. Among them, the sensors for biomedical applications are one of the most significant ones, which not only assist in improving the quality of human life but also help in the field of microfabrication by imparting knowledge about how to develop enhanced multifunctional sensing prototypes. The paper emphasises the use of silicon, in different forms, to fabricate electrodes and substrates for the sensors that are to be used for biomedical sensing. The electrical conductivity and the mechanical flexibility of silicon vary to a large extent depending on its use in developing prototypes. The article also explains some of the bottlenecks that need to be dealt with in the current scenario, along with some possible remedies. Finally, a brief market survey is given to estimate a probable increase in the usage of silicon in developing a variety of biomedical prototypes in the upcoming years.

show abstract

Section: Utilisation Of Silicon For Biomedical Applicationsmentioning

confidence: 99%

Silicon-Based Sensors for Biomedical Applications: A Review

Kundu

et al. 2019

Sensors

111

View full text Add to dashboard Cite

show abstract

“…Memristive silicon-wire devices are fabricated for this work through a top-down fabrication process utilizing Electron Beam (E-Beam) lithography and Deep Reactive Ion Etching (DRIE) processes [30]. Fig.…”

Section: Memristive Sensormentioning

confidence: 99%

“…The (1 × 1) cm 2 chip consisting of memristive devices, is thereafter wire-bonded on a specially designed chip-holder that can be easily plugged using board-to-board connectors to the main PCB allowing a flexible and robust sensing procedure. Further details are present in [30], [25].…”

Section: Memristive Sensormentioning

confidence: 99%

New Approach for Making Standard the Development of Biosensing Devices by a Modular Multi-Purpose Design

Tuoheti

Aiassa

Criscuolo

et al. 2020

IEEE Trans.on Nanobioscience

View full text Add to dashboard Cite

The fast widening of biosensing applications, such as healthcare, drug delivery, food, and military industries, is increasing the need for generality and compatibility among different sensors. To address this challenge, we present here an innovative approach for the fast development of new electronic biosensing systems, linking a custom-designed front-end with a multipurpose system. We envision an open tool to help designers to focus on the target molecule and related detection method instead of designing each time a dedicated electronic device. The architecture of the proposed system is based on a modular approach, where only the front-end and the software need to be custom redesigned according to the application. Considering current research and applying a rigorous definition of the technical requirements, the core of the system is designed to fit the highest number of biosensing methods. The flexibility of this approach is successfully demonstrated with three different types of biosensors, i.e., amperometric, ion-sensitive, and memristive.

show abstract

“…Memristive Si-NW devices were obtained through a top-down nanofabrication process as described by Tzouvadaki et al 21 The 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 12 incubated overnight in 2 μM of biotinylated anti-PSA DNA aptamer solution in PBS at 4 °C in a humidity chamber. Prior to use, biotinylated DNA aptamers were activated at 95 °C for 10 min before being gradually cooled to room temperature for 30 min 23 .…”

Section: Surface Modificationmentioning

confidence: 99%

Label-Free Ultrasensitive Memristive Aptasensor

et al. 2016

View full text Add to dashboard Cite

We present the very first worldwide ever-reported electrochemical biosensor based on a memristive effect and DNA aptamers. This novel device is developed to propose a completely new approach in cancer diagnostics. In this study, an affinity-based technique is presented for the detection of the prostate specific antigen (PSA) using DNA aptamers. The hysteretic properties of memristive silicon nanowires functionalized with these DNA aptamers provide a label-free and ultrasensitive biodetection technique. The ultrasensitive detection is hereby demonstrated for PSA with a limit of detection down to 23 aM, best ever published value for electrochemical biosensors in PSA detection. The effect of polyelectrolytes on our memristive devices is also reported to further show how positive or negative charges affect the memristive hysteresis. With such an approach, combining memristive nanowires and aptamers, memristive aptamer-based biosensors can be proposed to detect a wide range of cancer markers with unprecedent ultrasensitivities to also address the issue of an early detection of cancer.

show abstract

Memristive Biosensors for PSA-IgM Detection

Cited by 15 publications

References 26 publications

Silicon-Based Sensors for Biomedical Applications: A Review

Silicon-Based Sensors for Biomedical Applications: A Review

New Approach for Making Standard the Development of Biosensing Devices by a Modular Multi-Purpose Design

Label-Free Ultrasensitive Memristive Aptasensor

Contact Info

Product

Resources

About