Men with oligozoospermia had lower level of seminal plasma pyridoxine compared to normozoospermic men

Banihani, Saleem Ali; Aljabali, Shefa’ M.

doi:10.1016/j.heliyon.2022.e11983

Cited by 4 publications

(1 citation statement)

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“…In the multiple regression analysis, the results indicate that oligozoospermia, OAT, and hypospermia exhibited higher semen volume compared to normozoospermia among male infertility cases. Our findings were in similar line with earlier studies [ 40 , 41 ]. This study also detected the aging process has a substantial influence on sperm quantity and quality, similar to previous research reports [ 42 , 43 ].…”

Section: Discussionsupporting

confidence: 94%

Male Infertility: Causes and Management at a Tertiary Care Center in India

Choudhary,

Mishra,

Kumari

et al. 2023

Cureus

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BackgroundInfertility and problems of impaired fecundity have been a concern through the ages and are also considerable clinical problems today, affecting many couples worldwide. Most infertility cases are primarily attributed to male factors, which play a significant role. Additionally, a substantial number of these patients exhibit suboptimal sperm parameters. The study is mainly designed for individual intervention and outcome. We aim to evaluate the demographics, etiology, utilization of treatments, and outcomes of males undergoing infertility treatment. MethodologyWe retrospectively enrolled infertile couples from January 2021 to March 2023, covering the past two years. All patients were evaluated and investigated per the study protocol to identify the cause of infertility. ResultsTwo thousand three hundred forty-eight males were enrolled in the study, of whom 1,484 (63%) were found to have a standard semen analysis. A total of 868 (37%) had abnormal semen parameters. Two hundred and seventy-two (12%) patients completed the evaluation. All parameters, except for hypospermia, displayed lower percentages of motility compared to normozospermia. All semen parameters, except for hypospermia, showed a significantly lower normal morphology in comparison to normozospermia. This reduction increased by 10% for each year of age increment. ConclusionsThe study concluded by following a protocol for evaluating male patients. If an abnormal sperm parameter is identified before considering intracytoplasmic sperm injection (ICSI), it is recommended to conduct at least karyotyping and microdeletion analysis on the Y-chromosome's q arm.

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Section: Discussionsupporting

confidence: 94%

Male Infertility: Causes and Management at a Tertiary Care Center in India

Choudhary,

Mishra,

Kumari

et al. 2023

Cureus

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Role of pyridoxine and oxidative stress in asthenozoospermia

Bdeir,

Aljabali,

Banihani

2024

Heliyon

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Morphological and Molecular Bases of Male Infertility: A Closer Look at Sperm Flagellum

Pereira

Sousa

2023

Genes

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Infertility is a major health problem worldwide without an effective therapy or cure. It is estimated to affect 8–12% of couples in the reproductive age group, equally affecting both genders. There is no single cause of infertility, and its knowledge is still far from complete, with about 30% of infertile couples having no cause identified (named idiopathic infertility). Among male causes of infertility, asthenozoospermia (i.e., reduced sperm motility) is one of the most observed, being estimated that more than 20% of infertile men have this condition. In recent years, many researchers have focused on possible factors leading to asthenozoospermia, revealing the existence of many cellular and molecular players. So far, more than 4000 genes are thought to be involved in sperm production and as regulators of different aspects of sperm development, maturation, and function, and all can potentially cause male infertility if mutated. In this review, we aim to give a brief overview of the typical sperm flagellum morphology and compile some of the most relevant information regarding the genetic factors involved in male infertility, with a focus on sperm immotility and on genes related to sperm flagellum development, structure, or function.

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Men with oligozoospermia had lower level of seminal plasma pyridoxine compared to normozoospermic men

Cited by 4 publications

References 59 publications

Male Infertility: Causes and Management at a Tertiary Care Center in India

Male Infertility: Causes and Management at a Tertiary Care Center in India

Role of pyridoxine and oxidative stress in asthenozoospermia

Morphological and Molecular Bases of Male Infertility: A Closer Look at Sperm Flagellum

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