Meningite e endocardite infecciosa causada por Rhodotorula mucilaginosa em paciente imunocompetente

Loss, Sérgio Henrique; Antônio, Ana Carolina Peçanha; Roehrig, Cíntia; Castro, Priscylla Souza; Maccari, Juçara Gasparetto

doi:10.1590/s0103-507x2011000400017

Cited by 8 publications

(10 citation statements)

References 13 publications

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“…9,25 It appears that Rhodotorula meningitis should be considered a hospital infection, although there is one case of community acquired infection was reported. 19 In our case, it is very difficult to hypothesise the pathogenesis of meningitis. Our patient was a known case of abdominal Koch's with retroviral disease.…”

Section: Discussionmentioning

confidence: 67%

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Rhodotorula glutinis meningitis: a case report and review of literature

Menon

Gupta

Sequeira

et al. 2014

Mycoses

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Rhodotorula is ubiquitous saprophytic yeast belonging to phylum Basidiomycota. These encapsulated basidiomycetes are being increasingly recognised as important emerging human pathogens. There are scanty reports of meningitis caused by Rhodurorula spp in HIV infected patients. We present one such case of meningitis by Rhodutorula glutinis in HIV-infected patient. The patient also had a past history of abdominal tuberculosis. The diagnosis of Rhodotorula was confirmed by Gram staining and culture of the cerebrospinal fluid (CSF). Contamination was ruled out by repeated culturing of CSF from the same patient. Therapy with Amphotericin B showed good results. Patient was discharged from the hospital. However, in the seventh month of follow-up patient was readmitted with complaints of fever, breathlessness, altered sensorium, vomiting and succumbed to his illness. This time the CSF cultures remained negative for Rhodotorula, acid fast bacilli and other pyogenic organisms. Our last 11-year retrospective analysis of 8197 specimens received for mycological work-up showed that this is the first report of R. glutinis isolation from our institute.

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Section: Discussionmentioning

confidence: 67%

“…18 Immunocompetent individuals are also at the risk of infection by this fungus, but with low prevalence. 19 Meningitis caused by Rhodotorula species is still rare. Tuon and Costa [18] have taken a systematic review of 128 cases of Rhodotorula infections.…”

Section: Discussionmentioning

confidence: 99%

Rhodotorula glutinis meningitis: a case report and review of literature

Menon

Gupta

Sequeira

et al. 2014

Mycoses

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“…R. mucilaginosa is the most frequent species causing fungemia, which is responsible for up to 79% of infections, followed by R. glutinis (7.7%). These infections are often associated with the presence of CVCs or others implantable medical devices, and especially occur in immunocompromised individuals [6,8,12,23].…”

Section: Discussionmentioning

confidence: 99%

“…Although, endocarditis by Rhodotorula spp. has already been related to immunocompetent patients [8, 9] apparently without risk factor for opportunistic infection, invasive infections caused by this yeast are mainly associated with underlying immunosuppression. The most affected are patients with severe diseases such as leukemia, cancer or other solid tumors, lymphoproliferative disease, HIV, diabetes mellitus and submitted to various types of surgery [10–13].…”

Section: Introductionmentioning

confidence: 99%

Approaches by Rhodotorula mucilaginosa from a chronic kidney disease patient for elucidating the pathogenicity profile by this emergent species

Jarros¹,

Veiga²,

Corrêa³

et al. 2019

Preprint

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26Background: Traditionally known as a common contaminant, Rhodotorula mucilaginosa is 27 among the leading causes of invasive fungal infections by non-candida yeasts. They affect 28 mainly immunocompromised individuals, often mimicking the cryptococcosis infection, 29 despite invasive infections by Rhodotorula are still not well explained. Thus, here we aimed to 30 characterize microbiologically clinical isolates of R. mucilaginosa isolated from colonization 31 of a patient with chronic renal disease (CKD), as well as to evaluate their phylogeny, antifungal 32 susceptibility, virulence, and pathogenicity in order to infer the potential to become a possible 33 infection. 34 Methodology/Principal Findings: For this study, two isolates of R. mucilaginosa from oral 35 colonization of a CKD patient were isolated, identified and characterized by classical 36 (genotypic and phenotypic) methods. Susceptibility to conventional antifungals was evaluated, 37 followed by biofilm production, measured by different techniques (total biomass, metabolic 38 activity, colony forming units and extracellular matrix quantification). Finally, the 39 pathogenicity of yeast was evaluated by infection of Tenebrio molitor larvae. 40All isolates were resistant to azole and sensitive to polyenes and they were able to adhere and 41 form biofilm on the abiotic surface of polystyrene. In general, similar profiles among isolates 42 were observed over the observed periods (2, 24, 48 and 72 hours). Regarding extracellular 43 matrix components of biofilms at different maturation ages, R. mucilaginosa was able to 44 produce eDNA, eRNA, proteins, and polysaccharides that varied according to time and the 45 strain. The death curve in vivo model showed a large reduction in the survival percentage of 46 the larvae was observed in the first 24 hours, with only 40% survival at the end of the 47 Conclusions/Significance: We infer that colonization of chronic renal patients by R. 49 mucilaginosa offers a high risk of serious infection. And also emphasize that the correct 50 identification of yeast is the main means for an efficient treatment. 51 52 53 3 Author Summary 54The genus Rhodotorula is known to be a common contaminant, however, it has been 55 increasing in the last years, reports of different forms infections by this yeast, reaching mainly 56 individuals with secondary diseases or with low immunity. However, very little is known about 57 the mechanism that triggers the disease. Thus, this study aims to characterize microbiologically 58 clinical isolates of R. mucilaginosa isolated from a patient with chronic renal disease, as well 59 as to evaluate their phylogeny, antifungal susceptibility, virulence, and pathogenicity in order 60 to infer the potential to become a possible infection. It was possible to characterize in general 61 the clinical isolates, to determine that they are resistant to an important class of the antifungal 62 agents which are the azoles. In addition, they are able to adhere and to form biofilm on abiotic 63 surfaces, t...

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“…Although it has been previously considered as a nonpathogenic microorganism, this agent is currently recognized as potentially harmful to health, especially in immunocompromised patients, often being directly associated with catheters, prostheses and grafts, endocarditis, peritonitis, and meningitis. More recently, this microorganism has been implicated as the causal agent of onychomycosis (LOSS et al, 2011).…”

Section: Among the Yeasts Identii Ed To The Species Levelmentioning

confidence: 99%

Detection and identification of medically important microorganisms isolated from pigeon excreta collected in a university in a newly industrialized country

Xavier¹,

Lf²,

Brito³

et al. 2019

Biotemas

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A exposição humana a fezes de animais contaminados com microrganismos patogênicos representa um risco para a saúde. A presença de fungos e leveduras em ambientes está relacionada a efeitos adversos na saúde respiratória. A abordagem objetiva para a mitigação de possíveis efeitos à saúde devido à exposição a fungos e leveduras em ambientes fechados é difícil devido à falta de diretrizes. O objetivo deste trabalho foi conhecer as condições higiênico-sanitárias, identificar e caracterizar organismos de importância médica isolados de fezes de pombos coletadas na laje de um telhado de um prédio público. Para tais pontos, a coleta de excrementos foi estabelecida e os microrganismos foram identificados por métodos bioquímicos e microbiológicos padronizados, seguidos da abordagem proteômica de MALDI-TOF para a identificação do nível de espécie. Os resultados da identificação microbiana revelaram a presença de microrganismos de importância médica nas amostras analisadas, a saber: Candida krusei, Candida rugosa, Aspergillus spp., Cryptococcus neoformans, Klebsiella pneumoniae e Trichosporon asahii. Os resultados encontrados revelam a necessidade do desenvolvimento de metodologias que permitam mitigar os riscos à saúde humana devido à exposição a agentes patogênicos no ambiente examinado.

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Meningite e endocardite infecciosa causada por Rhodotorula mucilaginosa em paciente imunocompetente

Cited by 8 publications

References 13 publications

Rhodotorula glutinis meningitis: a case report and review of literature

Rhodotorula glutinis meningitis: a case report and review of literature

Approaches by Rhodotorula mucilaginosa from a chronic kidney disease patient for elucidating the pathogenicity profile by this emergent species

Detection and identification of medically important microorganisms isolated from pigeon excreta collected in a university in a newly industrialized country

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