Meningitis Caused by Bifidobacterium in an Infant

Hata, Daisuke; Yoshida, Akira; Ohkubo, Hideo; Mochizuki, Yasuhiro; Hosoki, Yoshiro; Tanaka, Ryuichiro; Azuma, Ryozo

doi:10.1097/00006454-198809000-00018

Cited by 41 publications

(12 citation statements)

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“…For instance, case reports have been published documenting Bifidobacterium breve meningitis and Pediococcus sepsis in infants with gastroschisis. 68,69 Although these cases were not associated with probiotic usage, they do highlight the concept that even presumed non-pathogenic organisms might cause infection in at-risk populations.…”

Section: Use Of Probiotics In the Critically Illmentioning

confidence: 80%

Safety assessment of probiotics for human use

et al. 2010

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The safety of probiotics is tied to their intended use, which includes consideration of potential vulnerability of the consumer or patient, dose and duration of consumption, and both the manner and frequency of administration. Unique to probiotics is that they are alive when administered, and unlike other food or drug ingredients, possess the potential for infectivity or in situ toxin production. Since numerous types of microbes are used as probiotics, safety is also intricately tied to the nature of the specific microbe being used. The presence of transferable antibiotic resistance genes, which comprises a theoretical risk of transfer to a less innocuous member of the gut microbial community, must also be considered. Genetic stability of the probiotic over time, deleterious metabolic activities, and the potential for pathogenicity or toxicogenicity must be assessed depending on the characteristics of the genus and species of the microbe being used. Immunological effects must be considered, especially in certain vulnerable populations, including infants with undeveloped immune function. A few reports about negative probiotic effects have surfaced, the significance of which would be better understood with more complete understanding of the mechanisms of probiotic interaction with the host and colonizing microbes. Use of readily available and low cost genomic sequencing technologies to assure the absence of genes of concern is advisable for candidate probiotic strains. The field of probiotic safety is characterized by the scarcity of studies specifically designed to assess safety contrasted with the long history of safe use of many of these microbes in foods.

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Section: Use Of Probiotics In the Critically Illmentioning

confidence: 80%

Safety assessment of probiotics for human use

et al. 2010

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“…However, these organisms have occasionally caused infections in people whose health is compromised in other ways. 3 4…”

Section: The Probiotic Conceptmentioning

confidence: 99%

Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health?

Macfarlane

Cummings²

1999

BMJ

275

179

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“…The reported side effects included bloating, diarrhoea, constipation, nausea and epigastric pain [35]. Occasionally probiotics can cause infections in immunocompromised individuals [36,37].…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome

2010

Clinical Governance: An Intl J

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Meningitis Caused by Bifidobacterium in an Infant

Cited by 41 publications

References 0 publications

Safety assessment of probiotics for human use

Safety assessment of probiotics for human use

Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health?

A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome

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