Meningitis Caused by Streptococcus suis in Humans

Arends, Jan P.; Zanen, H. C.

doi:10.1093/clinids/10.1.131

Cited by 400 publications

(339 citation statements)

References 26 publications

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“…Das 51 amostras isoladas, 30 pertenciam ao sorotipo 2 (50,8%) , 11 amostras (21,5%) ao sorotipo 3 , sete amostras (13,7%) pertenciam ao sorotipo 7, duas amostras (3,9%) ao sorotipo 1, e uma amostra (1,9%) ao sorotipo 14. Vale ressaltar a importância do isolamento de uma amostra pertencente ao sorotipo 14, pelo aspecto zoonótico já que foi descrito anteriormente por Arends & Zanen (1988) e por Zanen & Engel (1975) como agente etiológico de meningite em humanos.…”

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“…A identificação correta deste patógeno é importante, bem como a sua respectiva classificação sorológica, haja vista a conotação já mencionada de alguns sorotipos com meningites e ou septicemia em suínos, como também a importância de alguns deles causando enfermidade em humanos, mormente meningite (Zanen & Engel 1975, Arends & Zanen 1988, Gottschalk et al 1989.…”

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Sorotipagem de amostras de Streptococcus suis isoladas de suínos em granjas dos Estados de São Paulo, Minas Gerais e Paraná

et al. 2002

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Sorotipagem de amostras de Streptococcus suis isoladas de suínos em granjas dos Estados de São Paulo, Minas Gerais e Paraná

et al. 2002

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“…It can also cause meningitis in man (Arends & Zanen, 1988). Attempts to control the disease are still hampered by the lack of sufficient knowledge about the pathogenesis of the disease, and the lack of effective vaccines and sensitive diagnostic methods.…”

Section: Introductionmentioning

confidence: 99%

Environmentally regulated genes of Streptococcus suis: identification by the use of iron-restricted conditions in vitro and by experimental infection of piglets The GenBank accession numbers for the sequences determined in this work are AF302190–AF302207 (iri genes) and AF303226–303247 (ivs genes).

Smith¹,

Buijs²,

Vries³

et al. 2001

Microbiology

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The identification of environmentally regulated genes of Streptococcus suis by the use of iron-restricted conditions in vitro and by experimental infection of piglets is described. Eighteen unique iron-restriction-induced (iri) genes and 22 unique in-vivo-selected (ivs) genes of Strep. suis were found. None of the ivs genes was exclusively expressed in vivo. Four iri genes were identical to four clones selected in piglets. Two ivs genes were similar to genes for putative virulence factors. One of these ivs genes was identical to the epf gene of virulent Strep. suis serotype 2 strains and the other showed homology to a gene encoding a fibronectin-binding protein of Streptococcus gordonii. Two additional ivs genes showed homology to environmentally regulated genes previously identified by using an in vivo expression technology (IVET) selection system in other bacterial species. One of these showed similarity to the agrA gene of Staphylococcus aureus, a key locus involved in the regulation of numerous virulence proteins. The promoter selection system described in this paper has been successfully used for the identification of many environmentally regulated genes potentially involved in the pathogenesis of Strep. suis infections in piglets.

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“…Healthy carrier pigs harbouring the bacteria in nasal cavities or in tonsils also play an important role in the epidemiology and transmission of the infection [2,6,22]. Moreover, S. suis is a zoonotic agent [1,17,29].…”

Section: Introductionmentioning

confidence: 99%

Production of Muraminidase-Released Protein (MRP), Extracellular Factor (EF) and Suilysin by field isolates of Streptococcus suis capsular types 2, 1/2, 9, 7 and 3 isolated from swine in France

Berthelot-Hérault

Morvan²,

Keribin³

et al. 2000

Vet. Res.

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-A total of 323 isolates of Streptococcus suis recovered from diseased or healthy pigs in France were serotyped. The presence of virulence-related proteins, Muraminidase-Released Protein (MRP), Extracellular Factor (EF) and Suilysin was also studied in 122 isolates of capsular types 2, 1/2, 9, 7 and 3 to evaluate their implication in virulence of S. suis. Capsular types 2, 1/2, 9, 7 and 3 were the most frequently detected (93%), with 69% for the capsular type 2 alone. Capsular types 2, 1/2, 9, 7, 3, 1, 4, 8, 18, 10 and 12 were isolated from diseased pigs, whereas types 2, 7, 9, 1/2, and 3 originated from the nasal cavities or tonsils of healthy animals. Most of the S. suis type 2 isolates recovered from diseased pigs carried MRP+ EF-Suilysin-(46%) or MRP+ EF+ Suilysin+ (28%) phenotypes. The MRP+ EF-Suilysin-phenotype was also detected in 67% of S. suis type 2 strains isolated from healthy pigs. The production of the virulence-related proteins was less frequently found in S. suis types 1/2, 9, 7 and 3 recovered either from diseased or healthy pigs. In this study, all the capsular type 1/2 strains were MRP+ EF-Suilysin-and all the S. suis type 7 harboured an MRP-EF-Suilysin-phenotype. The MRP-EF-Suilysin-phenotype was found in S. suis types 2, 3, 7 and 9 isolated from septicaemia, meningitis, pneumonia, and pleurisy. These results suggest that the presence of these proteins should not be used as a single condition for classifying the virulence of a field isolate in France. Streptococcus suis / capsular type / virulence / swine

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Meningitis Caused by Streptococcus suis in Humans

Cited by 400 publications

References 26 publications

Sorotipagem de amostras de Streptococcus suis isoladas de suínos em granjas dos Estados de São Paulo, Minas Gerais e Paraná

Sorotipagem de amostras de Streptococcus suis isoladas de suínos em granjas dos Estados de São Paulo, Minas Gerais e Paraná

Production of Muraminidase-Released Protein (MRP), Extracellular Factor (EF) and Suilysin by field isolates of Streptococcus suis capsular types 2, 1/2, 9, 7 and 3 isolated from swine in France

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