Meniscus repair using mesenchymal stem cells – a comprehensive review

Yu, Hana; Adesida, Adetola B; Jomha, Nadr M.

doi:10.1186/s13287-015-0077-2

Cited by 77 publications

(63 citation statements)

References 94 publications

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“…No prior study has investigated the reparative capacity of C-PCs in the meniscus, which also consists of cartilaginous and fibrous tissue. Indeed, the most investigated cell-based meniscus repair strategies involves the use of stromal cells from the bone marrow to aid in the natural meniscal healing response [22]. BM-MSCs are capable of homing in and migrating to areas of injury and promoting tissue repair [23].…”

Section: Discussionmentioning

confidence: 99%

Human Cartilage-Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears

et al. 2018

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Meniscus injuries are among the most common orthopaedic injuries. Tears in the inner one-third of the meniscus heal poorly and present a significant clinical challenge. In this study, we hypothesized that progenitor cells from healthy human articular cartilage (C-PCs) may be more suitable than bone-marrow mesenchymal stem cells (BM-MSCs) to mediate bridging and reintegration of fibrocartilage tissue tears in meniscus. C-PCs were isolated from healthy human articular cartilage based on their expression of mesenchymal stem/progenitor marker ALCAM (CD166). Our findings revealed that healthy human C-PCs are CD166+, CD90+, CD54+, CD106- cells with multi-lineage differentiation potential and elevated basal expression of chondrogenesis marker SOX-9. We show that, similar to BM-MSCs, C-PCs are responsive to the chemokine stromal cell derived factor-1 (SDF-1) and they can successfully migrate to the area of meniscal tissue damage promoting collagen bridging across inner meniscal tears. In contrast to BM-MSCs, C-PCs maintaining reduced expression of cellular hypertrophy marker collagen X in monolayer culture and in an ex-plant organ culture model of meniscus repair. Treatment of C-PCs with SDF-1/CXCR4 pathway inhibitor AMD3100 disrupted cell localization to area of injury and prevented meniscus tissue bridging thereby indicating that the SDF-1/CXCR4 axis is an important mediator of this repair process. This study suggests that C-PCs from healthy human cartilage may potentially be a useful tool for fibrocartilage tissue repair/regeneration because they resist cellular hypertrophy and mobilize in response to chemokine signaling.

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Section: Discussionmentioning

confidence: 99%

Human Cartilage-Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears

et al. 2018

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“…Cell-based therapies represent an alternative approach to repair meniscus tears (18, 19) or for engineering meniscus implants (1, 20). However, our present knowledge of heterogeneous meniscus cell populations that inhabit and maintain this complex tissue is incomplete.…”

Section: Introductionmentioning

confidence: 99%

Relevance of meniscal cell regional phenotype to tissue engineering

Grogan

Pauli

Lotz

et al. 2017

Connective Tissue Research

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Purpose Meniscus contains heterogeneous populations of cells that have not been fully characterized. Cell phenotype is often lost during culture; however, culture expansion is typically required for tissue engineering. We examined and compared cell surface molecule expression levels on human meniscus cells from the vascular and avascular regions and articular chondrocytes while documenting changes during culture-induced dedifferentiation. Materials and Methods Expression of 16 different surface molecules were examined by flow cytometry after monolayer culture for 24 h, 1 week, and 2 weeks. Menisci were also immunostained to document the spatial distributions of selected surface molecules. Results Meniscus cells and chondrocytes exhibited several similarities in surface molecule profiles with dynamic changes during culture. A greater percentage of meniscal cells were positive for CD14, CD26, CD49c, and CD49f compared to articular chondrocytes. Initially, more meniscal cells from the vascular region were positive for CD90 compared to cells from the avascular region or chondrocytes. Cells from the vascular region also expressed higher levels of CD166 and CD271 compared to cells from the avascular region. CD90, CD166, and CD271-positive cells were predominately perivascular in location. However, CD166-positive cells were also located in the superficial layer and in the adjacent synovial and adipose tissue. Conclusions These surface marker profiles provide a target phenotype for differentiation of progenitors in tissue engineering. The spatial location of progenitor cells in meniscus is consistent with higher regenerative capacity of the vascular region, while the surface progenitor subpopulations have potential to be utilized in tears created in the avascular region.

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“…It is important to note that selection of the most recent studies precludes the reader from seminal works and the progression of the fields. This relevant data and knowledge can be found elsewhere (Aryaei, Vapniarsky, Hu, & Athanasiou, 2016; Athanasiou, Responte, Brown, & Hu, 2015; Chen, Duan, Zhu, Xiong, & Wang, 2014; Goldberg, Mitchell, Soans, Kim, & Zaidi, 2017; Gugjoo, Amarpal, Sharma, Aithal, & Kinjavdekar, 2016; Kazemnejad, Khanmohammadi, Baheiraei, & Arasteh, 2017; Scotti, Hirschmann, Antinolfi, Martin, & Peretti, 2013; Yu, Adesida, & Jomha, 2015). However, none have directly compared in vitro regenerative medicine approaches for the TMJ disc to other fibrocartilages.…”

Section: Introductionmentioning

confidence: 99%

A review of in-vitro fibrocartilage tissue engineered therapies with a focus on the temporomandibular joint

Lowe

Almarza

2017

Archives of Oral Biology

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The inability of fibrocartilage, specifically the temporomandibular joint (TMJ) disc, to regenerate and remodel following injury presents a unique problem for clinicians. Tissue engineering then offers a potential regenerative therapy. In vitro testing provides a valuable screening tool for potential tissue engineered solutions. The conclusions drawn for TMJ in vitro research were compared against state of the art fibrocartilage studies in the knee meniscus, and annulus fibrosus of the intervertebral disc (IVD). For TMJ disc regeneration, in vitro tissue engineered approaches, focused on cellular therapies with fibrochondrocytes, have displayed an inability to produce enough collagen, as well as an inability to recapitulate native mechanical properties. Biomaterial approaches have recapitulated the native properties of the TMJ disc, but their in vivo efficacy has yet to be determined. By comparison, the knee meniscus field is the most progressive in the use of stem cells as a cell source. The knee meniscus field has moved away from measuring mechanical properties, and are instead more focused on biochemistry and gene expression. IVD studies mainly use electrospun scaffolds, and have produced the best success in mechanical properties. The TMJ field, in comparison to knee meniscus and IVD, needs to employ stem cell therapies, new biomaterials and manufacturing techniques, and cutting edge molecular assays, in future in vitro approaches to screen for viable technologies to move to in vivo studies.

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Meniscus repair using mesenchymal stem cells – a comprehensive review

Cited by 77 publications

References 94 publications

Human Cartilage-Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears

Human Cartilage-Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears

Relevance of meniscal cell regional phenotype to tissue engineering

A review of in-vitro fibrocartilage tissue engineered therapies with a focus on the temporomandibular joint

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