Abstract:All women undergo the menopause transition (MT) in their lifetime, yet little is known of how this process impacts the human brain. The MT occurs in stages characterized by unique endocrine properties that impact aging trajectories of multiple organ systems including brain. This multi-modality neuroimaging study indicates that MT stages (pre-menopause, peri-menopause, and post-menopause) are associated with substantial differences in brain structure, connectivity, and energy metabolism in regions subserving hi… Show more
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