Menopause, skin and common dermatoses. Part 2: skin disorders

Abstract

In this second part of a four‐part review, we examine the effect of menopause on the skin. Menopause and the associated hypo‐oestrogenic state have implications for the structure and function of the skin. We performed a literature review to investigate the impact of the menopause on common dermatoses. There is evidence that oestrogen is implicated in transepidermal water loss and reduction in dermal collagen. There are associations with menopause and multiple common dermatoses, including xerosis and pruritus, hidradenitis suppurativa and psoriasis. Menopause has a clear impact on the skin and common dermatological conditions. Further research to understand the mechanisms and explore therapeutic options is needed.

Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology

“…In an explant model of fetal rat skin development, estrogen was shown to increase filaggrin expression 136 . Conversely, estrogen deficiency during menopause is associated with adverse skin changes such as loss of collagen, skin dryness and atrophy 137 , 138 . Overall, molecular alterations observed in the space flown mice and astronaut skin data show similarities with molecular effects associated with drugs like tretinoin and tamoxifen 123 , such as FLG and CASP14 downregulation, while symptoms reported in astronauts including dry skin and dermatitis also resemble side effects associated with drugs like tretinoin and tamoxifen 106 (Fig.…”

Psychometric properties of a Persian version of the Vulvovaginal Symptoms Questionnaire for measuring vulvovaginal symptoms in postmenopausal women

“…Because of the low level of estrogen, physiological and physical changes result in changes in the function and appearance of the genitourinary system, especially the vulva 21 . Some dermatologic conditions, such as xerosis and pruritus, psoriasis, and hidradenitis suppurativa, are associated with postmenopausal status 22 …”

“…21 Some dermatologic conditions, such as xerosis and pruritus, psoriasis, and hidradenitis suppurativa, are associated with postmenopausal status. 22 Few studies have evaluated the psychometric properties of the VSQ. A Spanish version of the VSQ showed acceptable validity, with a total Cronbach α coefficient of 0.871; this is in line with our results.…”

Unveiling the Nuances of Adult Female Acne: A Comprehensive Exploration of Epidemiology, Treatment Modalities, Dermocosmetics, and the Menopausal Influence

“…This low-estrogen state exerts a major impact on both skin structure and function. 101 Estrogen receptors are found throughout the skin, with their highest density seen in the face, genital area, and legs. 102 During menopause, dermal collagen is quickly lost, with around one-third collagen lost during the first five post-menopausal years.…”