Menthacarin, a Proprietary Peppermint Oil and Caraway Oil Combination, Improves Multiple Complaints in Patients with Functional Gastrointestinal Disorders: A Systematic Review and Meta-Analysis

Madisch, Ahmed; Frieling, Thomas; Zimmermann, Andrea; Hollenz, Margrit; Labenz, Joachim; Stracke, B; Miehlke, Stephan

doi:10.1159/000528553

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…However, more recently, the trial PERSUADE assessing small-intestinal release or ileocolonic release of peppermint oil showed that using the strict FDA and EMA endpoints, no significant reduction in overall symptom relief or abdominal pain was noted for both the preparations 96 . Recently, other formulations of essential oils were tested for IBS with promising results 97,98 . Otilonium bromide is a calcium channel blocker acting on the smooth muscle cells thus exerting a spasmolytic action.…”

Section: Abdominal Painmentioning

confidence: 99%

“…96 Recently, other formulations of essential oils were tested for IBS with promising results. 97,98 Otilonium bromide is a calcium channel blocker acting on the smooth muscle cells thus exerting a spasmolytic action. In a pooled analysis, otilonium bromide was more effective than placebo in improving abdominal pain in patients with IBS with a significant therapeutic effect after 10 weeks of treatment and a maximal effect after 15 weeks.…”

Section: Abdominal Pain Antispasmodicsmentioning

confidence: 99%

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Management of Irritable Bowel Syndrome With Diarrhea

Marasco,

Cremon,

Barbaro

et al. 2024

Journal of Clinical Gastroenterology

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Irritable bowel syndrome (IBS) with diarrhea (IBS-D) affects ~1% of the general population and is characterized by abdominal pain associated with diarrhea. IBS-D symptoms significantly impact the quality of life of patients. Major uncertainties remain regarding the optimal management of these patients. Several therapies have been investigated over the years for the treatment of IBS-D. In the initial management, commonly prescribed approaches with an effect on global IBS symptoms include a low Fermentable Oligo-, Di-, Mono-Saccharides and Polyols diet and probiotics, while antispasmodics are used for targeting abdominal pain and loperamide for diarrhea only. Additional therapeutic options for the relief of global IBS symptoms include rifaximin, 5-HT3 antagonists, gut-directed psychological therapies, and eluxadoline, while tricyclic antidepressants can target abdominal pain and bile acid sequestrants diarrhea. Promising evidence exists for the use of mesalazine and fecal microbiota transplantation in IBS-D, although further evidence is needed for definitive conclusions regarding their efficacy.

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Section: Abdominal Painmentioning

confidence: 99%

Section: Abdominal Pain Antispasmodicsmentioning

confidence: 99%

Management of Irritable Bowel Syndrome With Diarrhea

Marasco,

Cremon,

Barbaro

et al. 2024

Journal of Clinical Gastroenterology

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“…Peppermint extract contains several bioactive components, including menthol, menthone, and rosmarinic acid. Menthol has potent anti-H. pylori activity [61]. The dosage of peppermint extract varies depending on the specific product and the condition being treated.…”

Section: Peppermintmentioning

confidence: 99%

Recent Advances in Diagnosing and Treating Helicobacter pylori through Botanical Extracts and Advanced Technologies

Addissouky,

Ali,

El Tantawy El Sayed

et al. 2023

Arch Pharmacol Ther

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Helicobacter pylori (H. pylori) infection is a major global health concern, with an estimated 50% of the world's population infected. The bacterium colonizes the stomach and is associated with a range of gastrointestinal diseases, including chronic gastritis, peptic ulcers, and gastric cancer. The current standard of care for H. pylori infection involves a combination of antibiotics and proton pump inhibitors (PPIs), but the widespread use of antibiotics has led to the development of antibiotic-resistant strains of H. pylori, making treatment more difficult. Recent advances in diagnostic strategies include the use of non-invasive tests and serological biomarkers. While the use of antibiotics and PPIs remains the primary treatment approach, there is a growing interest in alternative therapies, including botanical extracts, natural products, and traditional medicines. Recent research has also explored the potential of probiotics, phage therapy, and novel antibiotics, such as rifabutin and furazolidone, in the treatment of H. pylori infection. Recent studies have also explored the potential of artificial intelligence (AI) in the diagnosis and management of H. pylori infection. AI-assisted screening methods have identified novel botanical extracts and natural products with anti-H. pylori activity, providing new avenues for therapeutic development. Additionally, AI can improve diagnostic accuracy and treatment outcomes. Although these alternative approaches show promise, further research is needed to confirm their efficacy, safety, and optimal dosing. Novel therapies such as phage therapy and new antibiotics may provide an alternative to traditional treatments and help overcome antimicrobial resistance.

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“…Herbal remedies exert a broad spectrum of pharmacological actions (multi-target approach) combined with proven good tolerability [ 8 ] . Some herbal compounds exert prokinetic or anti-infl ammatory actions; volatile essential oils like peppermint oil [ 9 ] or caraway oil have strong carminative eff ects due to defoaming and spasmolytic activities [ 10 ] . Other herbal compounds seem to in-fl uence the microbiome by antibacterial and antifungal eff ects.…”

Section: Introductionmentioning

confidence: 99%

Grapefruit Seed Extract Reduces Gastrointestinal Symptoms

Uehleke,

Storr,

Hörning

2024

Zeitschrift für Phytotherapie

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In this explorative longitudinal survey, self-reported data was collected from persons suffering from chronic gastrointestinal symptoms, who were seeking relief employing self-medication with a grapefruit seed extract (GKE). This is not a clinical trial nor a non-interventional study, but an explorative longitudinal survey with self-reports. The data was collected online and there were no personal contacts with a physician or a study nurse. Participants followed their own decision to use GKE and to provide their data to a data retrieval system, following informed consent according to existing national regulations on data protection. The test product was provided by the sponsor to make sure that the correct product was used for the intended observation period.Drop in criteria were chronic gastrointestinal symptoms, including those of functional dyspepsia (FD, resp. non-ulcer dyspepsia NUD) and/or irritable bowel syndrome (IBS) for more than 4 weeks, resulting in a score of an expanded Nepean Index (‘total gastrointestinal score’) higher than 20. Symptoms were documented 4–12 days (VA) prior to GKE use on day 1 and then on day 1, days 28, 42 and 56 of continuous oral use. New symptoms, predominating symptoms, stool habits, amount of oral intake and global status was retrieved every day during the observation period. On day 56 some global assessments were additionally recorded.The evaluation cohort was intended to be at least 100, and within the survey cohort we were able to evaluate 100 subjects (15 m and 85 f). Total gastrointestinal symptom score decreased from a mean (±SD) of 78.7±36.9 points by 26.4% on day 14, by 53.1% on day 28, by 58.7% on day 42, and by 49.9% on day 56, when compared to day 1. Upper gastrointestinal symptoms like heartburn improved better compared to lower GI symptoms (by 57.9% versus 47.3% on day 56). Overall complaints were rated as “very strongly improved” by 30%, “strongly improved” by 42%, “somewhat improved” or “unchanged” by 20% and as “deteriorated” by 1%. GKE was tolerated well. Minor adverse events reported were judged as most probably unrelated by the authors. More than half of the participants rated the intake as “very pleasant” or “pleasant” and intended to continue GKE beyond the observation period.In this prospective uncontrolled survey, GKE seemed to improve GI-symptoms, based on users reports. These results need to be confirmed in controlled clinical trials proofing efficacy and tolerance of GKE in functional GI-diseases. Data collected from participants without any personal contact bear a high risk of bias. Evaluation of self-treatment as presented here is clearly restricted to marketed products and may report interesting details of self-treatment outside prescription settings.

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Menthacarin, a Proprietary Peppermint Oil and Caraway Oil Combination, Improves Multiple Complaints in Patients with Functional Gastrointestinal Disorders: A Systematic Review and Meta-Analysis

Cited by 7 publications

References 41 publications

Management of Irritable Bowel Syndrome With Diarrhea

Management of Irritable Bowel Syndrome With Diarrhea

Recent Advances in Diagnosing and Treating Helicobacter pylori through Botanical Extracts and Advanced Technologies

Grapefruit Seed Extract Reduces Gastrointestinal Symptoms

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