Mercury and Lead Content in Fish Species From the River Gomti, Lucknow, India, as Biomarkers of Contamination

Agarwal, Renu; Kumar, Rakesh; Behari, Jai Raj

doi:10.1007/s00128-007-9035-8

Cited by 62 publications

(20 citation statements)

References 9 publications

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“…Our findings showed that both NAC and DMSA ameliorated the decrease in serum and mRNA expression of antioxidants. These findings were confirmed in previous reports for both LA and HgCl 2 using curcumin and selenium, respectively (Agarwal et al, 2007;Ahn et al, 2002; Abu El-Saad et al, 2016). NAC interacts most powerfully with the free radicals, it exerts an indirect effect on antioxidant status, since it restores catalase and is a precursor for synthesis of GSH, (Arakawa & Ito, 2007) thus providing enhanced defense against toxin-induced oxidative insult (Abu El-Saad & Elgerbed, 2010).…”

Section: Discussionsupporting

confidence: 90%

“…It causes degradation in proteins, lipids, and DNA (Halliwell & Gutteridge, 1990). Like kidney, liver is one of the targets for lead and mercury; it reacts by increasing the activity of transaminases (Mehana et al, 2012;Agarwal et al, 2007) in acute intoxication. Here, in chronic study both LA and HgCl 2 attenuated antioxidants levels and expression and increased liver transaminases.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

Baiomy¹,

Soliman²,

Saad³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Heavy metals that normally cause problems are mercury (HgCl 2 ) and lead acetate (LA). Chelating and inhibitor agents are the target to treat and overcome metal toxicity. The current study has been carried out to evaluate the protective effects of N-acetyl cysteine (NAC) and meso 2,3 dimercaptosuccinic acid (DMSA) against HgCl 2 and LA toxicity. Materials and Methods: Ninety male Wistar rats were divided into nine equal groups. The groups were administered NAC and/or DMSA in presence or absence of LA (LA; 0.2% in drinking water) or HgCl 2 (2 mg/kg BW) for 2 consecutive months. Serum and organs were collected for biochemical, genetic and histopathological changes. Results: Biochemical results revealed that LA and HgCl 2 significantly increased the levels of liver and kidney biomarkers. Administration of NAC and DMSA considerably improved these altered changes. LA and HgCl 2 decreased serum levels of antioxidants and were ameliorated in NAC and DMSA administered rats. LA and HgCl 2 administration upregulated expression of IL-1β and IL-8 that were normalized by NAC and DMSA. Kidneys of LA and HgCl 2 groups showed intraluminal hyaline casts. Kidneys of DMSA-administrated rats showed mild hydropic degeneration of renal tubular epithelium in LA and HgCl 2 groups. Kidneys of NAC administrated rats showed atrophy of capillary tufts. Kidneys of LA and HgCl 2 administered rats which received DMSA and NAC showed normal glomerular structure. Liver histopathology showed sever changes that were ameliorated by NAC and DMSA. Conclusion: Taken together, usage of NAC and DMSA provide significant protection against LA and HgCl 2 -induced hepatotoxicity and nephrotoxicity in male Wistar rats.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

Baiomy¹,

Soliman²,

Saad³

et al. 2017

Afr J Tradit Complement Altern Med

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“…Moreover, biological factors of the fish such as age and body size could play a role in the bioavailability of metals (Peakall and Burger 2003). The use of wild and cultured food fishes as biomonitors of metal pollution in aquatic ecosystems is becoming popular throughout the world (Norrgren et al 2000;Mansour and Sidky 2002;Bervoets and Blust 2003;Marcovecchio 2004;Begum et al 2005;Demirak et al 2005;Storelli et al 2006;Agarwal et al 2007;Ploetz et al 2007). However, only a few studies have been carried out to monitor metal pollution in food fish species in Sri Lanka.…”

Section: Introductionmentioning

confidence: 99%

Heavy metal levels in two food fish species from Negombo estuary, Sri Lanka: Relationships with the body size

Indrajith¹,

Pathiratne

2010

Sri Lanka J. Aquat.

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The present study was carried out to assess the levels of eight metals viz. Pb, Cu, Cd, Ni, Cr, Mn, Hg and Zn in two species of food fish, Etroplus suratensis and Ambassis commersoni from Negombo estuary. The levels of Hg were analyzed by cold vapour atomic absorption spectrometry whereas the other metals were analyzed by flame/graphite furnace atomic absorption spectrometry. Total metal levels in muscle, gill and liver tissues of the fish showed a wide range. Accumulation of most metals in the tissues of the fish followed the increasing order, muscle < gills ≤ liver. Of the different metal levels detected in the fish, only the level of Cd in liver tissue of 6% of E. suratensis and 12% of A. commersoni exceeded the level specified for human consumption by European Union. Interspecies comparisons revealed that mean level of Zn in the muscle tissue of A. commersoni was two fold higher than that of E. suratensis. The levels of metals in the muscle tissue of both fish species were positively correlated with the body weight or body length of the fish. Based on the levels of Hg, Pb, and Cd in the fish, edible muscle of both fish species collected from the estuary was found to be safe for human consumption. However, heavy consumption of bigger size fish may pose a health risk to the consumers as there were strong positive correlations between body weight or body length and metal levels in muscle tissues of both species of fish. H.A.P. Indrajith et al./ Sri Lanka J. Aquat. Sci. 13 (2008): 63-81

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“…The significant decrease in the packed cell volume (PCV) in this study could be attributed to kidney damage and or impaired osmoregulation causing anaemia and haemodilution [43]. The increase in white blood cell could be associated with an increase in antibody production in response to the extracts which help in long survival of the mice exposed [44]. Changes in haematological values occur in relation to physiological stress, diseases and toxic environmental conditions [40].…”

Section: Haematological Analysis and Histopathologymentioning

confidence: 76%

The effect of heavy metal air pollution arising from local metallurgical activities on albino rat

Ugya¹,

Imam²

2017

Am J Prev Med Public Health

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Introduction:The ecological equilibrium of the earth is endangered by the chemical process industries as most industries continue to spew chemical toxicants into the environment. Since local metallurgical activity is inevitable in Nigeria. Aim: This research is aimed at assessing the effect of heavy metals air pollution arising from local metallurgical activities on Albino rat. Methods: Particular matter samples were collected for 24h at four different sites twice a month using a high volume air sampler. Point A is Bakin Dogo Market, Point B is Old Panteka market, Point C is new Panteka market and Point D is U/Ma'azu. All the collected samples were analyzed for heavy metals using standard laboratory procedures. Six hundred newly born male albino rats were collected from National Institution for Trypanosomiasis Research (NITR) and were exposed to the sampling points twenty four hours daily via out the experimental period. Mortality, haematological and histological parameters were investigated. The rat tissues were also digested for the determination of Bioconcentration factor (BCF).Result: The result obtained shows high Concentration of heavy metals (Pb, Cd, Cu and Ni) above the recommended limit by European commission (EC), World health organization (WHO) and NEPM (National Environmental Protection Measures). Higher BCF was obtained for all the heavy metals (Pb, Ni, Cu and Cd) which was attributed to the higher changes in Mortality, haematological and histological parameters if compare to the control. Conclusion:The studies shows how heavy metal air pollution could cause Mortality and also bring about changes in haematological and histological parameters, which resulted due to high BCF. It is thereby recommended that local metallurgical activities should be closely monitored by environmental agencies such as Kaduna state environmental protection agencies (KEPA) and Federal environmental protection agencies (FEPA). The government should also make regulations that will mandate the paying of environmental degradation tax owing to the daily multiplication of vehicles and other automobile materials. ARTICLE HISTORY

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Mercury and Lead Content in Fish Species From the River Gomti, Lucknow, India, as Biomarkers of Contamination

Cited by 62 publications

References 9 publications

Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

Heavy metal levels in two food fish species from Negombo estuary, Sri Lanka: Relationships with the body size

The effect of heavy metal air pollution arising from local metallurgical activities on albino rat

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