Merkel cell distribution in the human eyelid

May, Christian Albrecht; Osterland, I.

doi:10.4081/ejh.2013.e33

Cited by 10 publications

(6 citation statements)

References 14 publications

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“…Studies indicate that the presence of neuropeptides, accumulated near the nerve fibre junction, signifies their action in the expression of voltage gated ion channels which are essential for synaptic transmission. However, conflicting evidence, using histochemical markers, suggests a paracrine function of Merkel cells [ 12 ].…”

Section: Merkel Cell Carcinomamentioning

confidence: 99%

Merkel Cell Polyomavirus: Molecular Insights into the Most Recently Discovered Human Tumour Virus

Stakaitytė

Wood

Knight

et al. 2014

Cancers

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A fifth of worldwide cancer cases have an infectious origin, with viral infection being the foremost. One such cancer is Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy. In 2008, Merkel cell polyomavirus (MCPyV) was discovered as the causative agent of MCC. It is found clonally integrated into the majority of MCC tumours, which require MCPyV oncoproteins to survive. Since its discovery, research has begun to reveal the molecular virology of MCPyV, as well as how it induces tumourigenesis. It is thought to be a common skin commensal, found at low levels in healthy individuals. Upon loss of immunosurveillance, MCPyV reactivates, and a heavy viral load is associated with MCC pathogenesis. Although MCPyV is in many ways similar to classical oncogenic polyomaviruses, such as SV40, subtle differences are beginning to emerge. These unique features highlight the singular position MCPyV has as the only human oncogenic polyomavirus, and open up new avenues for therapies against MCC.

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Section: Merkel Cell Carcinomamentioning

confidence: 99%

Merkel Cell Polyomavirus: Molecular Insights into the Most Recently Discovered Human Tumour Virus

Stakaitytė

Wood

Knight

et al. 2014

Cancers

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“…The posterior lamella, including the mucocutaneous junction and lid wiper areas, contain simple and Meissner corpuscles [176]. Mechano-nociceptors, such as Merkel's disks and Meissner corpuscles, respond to hair movement and light touch, respectively, but are rare in the eyelid, occurring around the cilia roots and being more prevalent in the central compared to the outer eyelid margin [192]. The eyelid margin is more sensitive than other conjunctival areas, but less sensitive than the cornea [175,193].…”

Section: Eyelid Neuroanatomymentioning

confidence: 99%

BCLA CLEAR - Anatomy and physiology of the anterior eye

Downie

Bandlitz

Bergmanson

et al. 2021

Contact Lens and Anterior Eye

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A key element of contact lens practice involves clinical evaluation of anterior eye health, including the cornea and limbus, conjunctiva and sclera, eyelids and eyelashes, lacrimal system and tear film. This report reviews the fundamental anatomy and physiology of these structures, including the vascular supply, venous drainage, lymphatic drainage, sensory innervation, physiology and function. This is the foundation for considering the potential interactions with, and effects of, contact lens wear on the anterior eye. This information is not consistently published as academic research and this report provides a synthesis from all available sources. With respect to terminology, the report aims to promote the consistent use of nomenclature in the field, and generally adopts anatomical terms recommended by the Federative Committee for Anatomical Terminology. Techniques for the examination of the ocular surface are also discussed.

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“…Mostly they are concentrated in the palms of hands, predominantly in the finger pads, also in the soles and toes than in any other parts of the body [7]. They are also present in the lips, hard palate, gingiva [4], oesophagus [8], and human eyelid [9]. Concentration of MCs in the external genitalia has not been studied, but Cold and Taylor [10] detected some MCs in the male prepuce and in the female clitoris.…”

Section: Merkel Cellsmentioning

confidence: 99%

Merkel Cells and Merkel Cell Carcinoma of Genitourinary System Tumor with Aggressive Behavior and Poor Prognosis

Polakovičová¹,

Polák²

2017

Anat Physiol

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Human Merkel cells (MCs) were first described by Friedrich S. Merkel in 1875 and named "Tastzellen" (touch cells). Merkel cells are primarily localized in the basal layer of the epidermis and concentrated in touch-sensitive areas. Their density varies among each anatomical site. Mostly they are concentrated in the palms of hands, predominantly in the finger pads, also in the soles and toes than in any other parts of the body. Concentration of MC in the external genitalia has not been studied, but some researchers detected some MCs in the male prepuce and in the female clitoris. Last year they were first described in the labia minora. Functionally they can be classified into some subpopulations with different functions: mechanoreceptive, endocrine, chemo sensitive. They belong to mechanoreceptors detecting tissue deformations and release various neurotransmitters to nerve endings. Tumor arising from Merkel cells called Merkel cell carcinoma (MCC). This highly aggressive malignancy occurs most often in the elderly white peoples on the skin of the head, neck and extremities. Its incidence is generally higher in men than in women. The rate of mortality is higher than in patients with melanoma and prognosis is rather poor. MCC of the genitourinary system are very rare, aggressive and may be misinterpreted with other cancers of genitourinary system. Most cases of MCC reported in the English literature in the women are in the vulva. In general MCC have an aggresive behavior, but those in the vulva are virulent with a 100% rate of inguinal node and also distant metastases. Prognosis of this carcinoma is very poor than prognosis of the MCC arising in other parts of the body.

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Merkel cell distribution in the human eyelid

Cited by 10 publications

References 14 publications

Merkel Cell Polyomavirus: Molecular Insights into the Most Recently Discovered Human Tumour Virus

Merkel Cell Polyomavirus: Molecular Insights into the Most Recently Discovered Human Tumour Virus

BCLA CLEAR - Anatomy and physiology of the anterior eye

Merkel Cells and Merkel Cell Carcinoma of Genitourinary System Tumor with Aggressive Behavior and Poor Prognosis

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