Mesalazine Suppositories versus Hydrocortisone Foam in Patients with Distal Ulcerative Colitis:A Comparison of the Efficacy and Practicality of Two Topical Treatment Regimens

Farup, Per G.; Hovde, Øistein; Halvorsen, Fred-Arne; Raknerud, N; Brodin, Ulf

doi:10.3109/00365529509093256

Cited by 84 publications

(55 citation statements)

References 23 publications

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“…These patients usually need long-term treatment, not only to induce remission during flare-ups, but also to prevent relapses and/or further complications. Those studies in IBD patients (mainly ulcerative colitis [UC]) where compliance has been specifically assessed, have shown adherence rates of 20% and 50%, for short-and long-term treatments, respectively [3][4][5][6]; these figures are very close to those reported for other chronic diseases [7]. However, data regarding adherence in IBD patients are scarce and most studies have been addressed exclusively to maintenance treatment with aminosalicylates in inactive UC [8].…”

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confidence: 92%

Medication-Taking Behavior in a Cohort of Patients with Inflammatory Bowel Disease

et al. 2006

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Recent studies have shown a low adherence rate to maintenance treatment in patients with inflammatory bowel disease (IBD). We sought to assess the medication-taking behavior in a cohort of patients with IBD. We prospectively included IBD patients from the outpatient clinic who agreed to answer a questionnaire about prescribed treatment and adherence. Physicians registered clinical data including prescribed medications. Two hundred fourteen patients (115 Crohn's disease/99 ulcerative colitis) were included. The most prescribed medications were oral mesalazine (56.5%) and immunomodulators (41.1%). Forty-three percent of patients admitted to occasionally forgetting to take their medication but only 7.5% of them did it voluntary. Oral mesalazine and azathioprine were the drugs with the poorest compliance, with nonadherence rates of 45% and 25% of the total prescribed doses, respectively. The only factor associated with a better adherence was a more complicated course of the disease-steroid dependency, steroid refractoriness, need for infliximab treatment, hospitalization, or surgery (P=.02). Twenty percent of patients admitted to self-medicating. An important proportion of patients with IBD admit to forget some doses of the prescribed medication in the setting of a specialized unit of a referral centre.

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confidence: 92%

Medication-Taking Behavior in a Cohort of Patients with Inflammatory Bowel Disease

et al. 2006

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“…Significant early disappearance of rectal bleeding was also recognized at day 3 with mesalazine suppository. Mesalazine suppository was also significantly effective than rectal steroid in patients with ulcerative proctitis [23]. Mesalazine suppository is also a useful tool for treating pediatric ulcerative proctitis.…”

Section: Treatmentmentioning

confidence: 99%

Optimized Management of Ulcerative Proctitis: When and How to Use Mesalazine Suppository

et al. 2018

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Background: Ulcerative proctitis, one of the disease types of ulcerative colitis, is considered one of the initial manifestations of ulcerative colitis. Prevention of aggravation of ulcerative proctitis is important for improving the prognosis of ulcerative colitis. Here we reviewed the epidemiology, diagnosis, and management of ulcerative proctitis. Summary: The number of patients with ulcerative proctitis is increasing. Disease extension occurs in many patients with ulcerative proctitis. Differential diagnosis from other chronic proctitis is important and should be performed based on the clinical history and endoscopical and histological features. Mesalazine suppository has been the first-line therapy for patients with ulcerative proctitis because of its high effectiveness and safety. Topical treatment of ulcerative proctitis, particularly using mesalazine suppository has been underused in clinical practice. Key Messages: Mesalazine suppositories are more effective than dose intensification of oral mesalazine for relapsed patients with maintenance dose of oral mesalazine. However, low adherence to rectal mesalazine has hindered remission in patients with ulcerative proctitis.

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“…Data on nonpregnant patients with UC, however, have demonstrated much variation in nonadherence rates of maintenance therapy, ranging from 20% for shortterm to 60% for long-term therapy. 12,[15][16][17][18] Among pregnant women with Crohn's disease (CD), forgetfulness and fear for fertility and/or the fetus have been suggested as predictors for nonadherence prior to and during pregnancy. 19 Yet it is unclear whether these factors may be associated with adherence to medical treatment among pregnant women with UC.…”

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Self-reported adherence to medical treatment prior to and during pregnancy among women with ulcerative colitis

Julsgaard

Nørgaard

Hvas

et al. 2011

Inflammatory Bowel Diseases

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Mesalazine Suppositories versus Hydrocortisone Foam in Patients with Distal Ulcerative Colitis:A Comparison of the Efficacy and Practicality of Two Topical Treatment Regimens

Abstract: Both treatment regimens are effective; mesalazine suppositories seem to be the preferred alternative.

Cited by 84 publications

References 23 publications

Medication-Taking Behavior in a Cohort of Patients with Inflammatory Bowel Disease

Medication-Taking Behavior in a Cohort of Patients with Inflammatory Bowel Disease

Optimized Management of Ulcerative Proctitis: When and How to Use Mesalazine Suppository

Self-reported adherence to medical treatment prior to and during pregnancy among women with ulcerative colitis

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