2022
DOI: 10.1016/j.arr.2022.101763
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Mesencephalic astrocyte-derived neurotrophic factor (MANF): Structure, functions and therapeutic potential

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Cited by 18 publications
(11 citation statements)
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“…We hypothesized that the consumption of MANF could be sufficient, as supplementation with MANF showed protective effects in liver injury models. 29 Previous studies also showed that MANF may serve as a biomarker for ER stress-mediated kidney disease. 30,31 MANF provided protective effects in lipopolysaccharide-induced acute kidney injury.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…We hypothesized that the consumption of MANF could be sufficient, as supplementation with MANF showed protective effects in liver injury models. 29 Previous studies also showed that MANF may serve as a biomarker for ER stress-mediated kidney disease. 30,31 MANF provided protective effects in lipopolysaccharide-induced acute kidney injury.…”
Section: Discussionmentioning
confidence: 99%
“…However, the MANF concentrations significantly decreased when ALP and γ ‐GT levels were above the upper limit of normal in our study. We hypothesized that the consumption of MANF could be sufficient, as supplementation with MANF showed protective effects in liver injury models 29 …”
Section: Discussionmentioning
confidence: 99%
“…Neurotrophic factors are critical for neuronal survival as they promote neuronal proliferation, survival, and differentiation [ 117 ]. Neurotrophic factors regulate a variety of neurological activities in ischemic stroke, including neuroprotection [ 118 ], neuroplasticity [ 119 ], and vascular remodeling [ 120 ]. Several studies have shown that neurotrophic factors can be a treatment option for ischemic stroke [ 121 , 122 , 123 ].…”
Section: Applications Of Plga-based Nanostructures In Drug Delivery A...mentioning
confidence: 99%
“…The mesencephalic astrocyte‐derived neurotrophic factor (MANF), originating from midbrain astrocytes, also exerts a significant effect on the regulation of neuroinflammatory responses after TBI. MANF is a secreted protein with highly conserved genes, which belongs to the neurotrophic factor superfamily together with neurotrophins 38 . It not only functions as a secreted neurotrophic factor but also is an intracellular protein.…”
Section: Mechanism Of Neurotrophins In Tbimentioning
confidence: 99%
“…MANF is a secreted protein with highly conserved genes, which belongs to the neurotrophic factor superfamily together with neurotrophins. 38 It not only functions as a secreted neurotrophic factor but also is an intracellular protein. Increasing evidence reveals that it can inhibit the necrosis/apoptosis of cerebral cortex cells and protect neurons from cerebral ischemia.…”
Section: Mechanism Of Neurotrophins In Tbimentioning
confidence: 99%