Mesenchymal stem cell-based angiotensin-converting enzyme 2 in treatment of acute lung injury rat induced by bleomycin

Abstract

This research provided clues for the development of effective therapeutic methods to ALI using stem cell transplantation and gene therapy.

Mesenchymal Stromal Cells in Animal Bleomycin Pulmonary Fibrosis Models: A Systematic Review

“…Lung TNF‐α mRNA level was also decreased by umbilical cord MSCs in the other Moodley et al study [24]. In the Gao et al study, MSC therapy increased TNF‐α protein level when measured 13 days after MSC administration but not at earlier time points [14]. There was no change in TNF‐α protein level in the Min et al study [25].…”

“…Improvement in fibrosis was reported in six studies [11, 12, 18, 20, 22, 23], and a decrease in inflammation was reported in five studies [15, 16, 18, 24]. The Gao et al study reported less improvement with MSCs alone than with MSCs transfected with ACE2 [14]. Thus, substantial improvement was seen in 11 of 12 studies.…”

“…BAL neutrophil count was assessed in four studies, all of which found it to be decreased by MSC therapy [12, 14, 15, 18]. In the Kumamoto et al study, there was a significant effect both with 9‐day‐cultured MSCs and 2‐hour‐adherent MSCs [12].…”

“…Survival was assessed and was found to be improved by MSC therapy in four studies [11, 12, 14, 15]. It was significantly improved in the Kumamoto et al study [12] by 2‐hour‐adherent MSCs but not by 9‐day‐cultured MSCs.…”

“…In some cases, we performed analyses on individual study data. Survival data from two studies [14, 15], analyzed with the Kaplan‐Meier method, were compared between groups using the log‐rank test. Lung matrix metalloproteinase‐2 (MMP‐2) and MMP‐13 were compared between groups using Student's t test in one study [16].…”