Mesenchymal Stem Cell-Derived Exosomes as Drug Carriers for Delivering miRNA-29b to Ameliorate Inflammation in Corneal Injury Via Activating Autophagy

Liu, Jinghua; Gao, Juan; Lu, Ping; Wang, Yuchuan; Xing, Shulei; Yan, Yarong; Han, Ruifang; Hao, Peng; Li, Xuan

doi:10.1167/iovs.65.6.16

Invest. Ophthalmol. Vis. Sci.

2024

DOI: 10.1167/iovs.65.6.16

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Mesenchymal Stem Cell-Derived Exosomes as Drug Carriers for Delivering miRNA-29b to Ameliorate Inflammation in Corneal Injury Via Activating Autophagy

Jinghua Liu,

Juan Gao,

Ping Lu

et al.

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2024

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Cited by 3 publications

References 66 publications

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Downregulation of microRNA-29b in cancer and fibrosis: molecular insights and clinical implications

Shinde,

Chitkara,

Mittal

2024

Drug Discovery Today

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Downregulation of microRNA-29b in cancer and fibrosis: molecular insights and clinical implications

Shinde,

Chitkara,

Mittal

2024

Drug Discovery Today

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Healing the Cornea: Exploring the Therapeutic Solutions Offered by MSCs and MSC-derived EVs

Jammes,

Tabasi,

Bach

et al. 2024

Progress in Retinal and Eye Research

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Corneal Treatment, Repair, and Regeneration: Exosomes at Rescue

Robbins,

Montreuil,

Kundu

et al. 2024

Pharmaceutics

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Exosomes are extracellular vesicles within the nanosized range that play roles in intercellular communication and thus have certain biological activities. The secretory signaling communication mechanism is an efficient way of exchanging information between cells and has been investigated as nature’s therapeutic drug carriers. This review will summarize the potential of exosomes as therapeutic tools and drug delivery vehicles for corneal pathologies. The cornea is an avascular ocular tissue, and its healing is a complex process including cell death and migration, cell proliferation and differentiation, and extracellular matrix remodeling. Here, we discussed the structure, barrier, phases, and healing cascade of cornea. We briefly reviewed the immunogenicity and toxicity of exosomes and role of exosomes in preserving cornea. Additionally, we provided combining exosome strategies with hydrogels, gene and stem cells therapy focused on corneal treatment, repair, and regeneration.

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Mesenchymal Stem Cell-Derived Exosomes as Drug Carriers for Delivering miRNA-29b to Ameliorate Inflammation in Corneal Injury Via Activating Autophagy

Cited by 3 publications

References 66 publications

Downregulation of microRNA-29b in cancer and fibrosis: molecular insights and clinical implications

Downregulation of microRNA-29b in cancer and fibrosis: molecular insights and clinical implications

Healing the Cornea: Exploring the Therapeutic Solutions Offered by MSCs and MSC-derived EVs

Corneal Treatment, Repair, and Regeneration: Exosomes at Rescue

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