Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization

Wang, Jiangmei; Xia, Jie; Huang, Ruoqiong; Hu, Yinan; Fan, Jiajie; Shu, Qiang; Xu, Jianguo

doi:10.1186/s13287-020-01937-8

Cited by 82 publications

(56 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From our systematic review, we found that MSCs induce M2 macrophages, consistent with findings in previous studies. With the increasing relevance of cell therapy, the anti-inflammatory and immunomodulatory nature of MSCs through M2 macrophages makes MSCs an attractive therapeutic option for many diseases [69]. MSC-mediated macrophage polarization has been shown to be beneficial in a myriad of conditions ranging from traumatic spinal cord injury to tendon rupture to dilated cardiomyopathy [70].…”

Section: Discussionmentioning

confidence: 99%

The Crosstalk between Mesenchymal Stem Cells and Macrophages in Bone Regeneration: A Systematic Review

Shin

Lee

Shen

et al. 2021

Stem Cells International

View full text Add to dashboard Cite

Bone regeneration is a complex and well-coordinated process that involves crosstalk between immune cells and resident cells in the injury site. Transplantation of mesenchymal stem cells (MSCs) is a promising strategy to enhance bone regeneration. Growing evidence suggests that macrophages have a significant impact on osteogenesis during bone regeneration. However, the precise mechanisms by which macrophage subtypes influence bone regeneration and how MSCs communicate with macrophages have not yet been fully elucidated. In this systematic literature review, we gathered evidence regarding the crosstalk between MSCs and macrophages during bone regeneration. According to the PRISMA protocol, we extracted literature from PubMed and Embase databases by using “mesenchymal stem cells” and “macrophages” and “bone regeneration” as keywords. Thirty-three studies were selected for this review. MSCs isolated from both bone marrow and adipose tissue and both primary macrophages and macrophage cell lines were used in the selected studies. In conclusion, anti-inflammatory macrophages (M2) have significantly more potential to strengthen bone regeneration compared with naïve (M0) and classically activated macrophages (M1). Transplantation of MSCs induced M1-to-M2 transition and transformed the skeletal microenvironment to facilitate bone regeneration in bone fracture and bone defect models. This review highlights the complexity between MSCs and macrophages, providing more insight into the polarized macrophage behavior in this evolving field of osteoimmunology. The results may serve as a useful reference for definite success in MSC-based therapy based on the critical interaction with macrophages.

show abstract

Section: Discussionmentioning

confidence: 99%

The Crosstalk between Mesenchymal Stem Cells and Macrophages in Bone Regeneration: A Systematic Review

Shin

Lee

Shen

et al. 2021

Stem Cells International

View full text Add to dashboard Cite

show abstract

“…Administration of MSCs has been shown to induce M2 polarization through various pathways [ 106 , 151 , 152 , 153 , 154 , 155 , 156 , 157 ]. MSC exosomes contain miR-322, which suppresses the expression of pknox1, a protein that encourages the M1 phenotype, thus promoting M2 [ 157 ].…”

Section: Effect Of Msc Derived Extracellular Vesicles On Neuro-vascular Unit After Strokementioning

confidence: 99%

“…MSC-EVs have been reported to provide beneficial effect on neurons through various mechanisms. miR-210, which can be delivered via MSC-EVs, show various effects on neurogenesis following brain injury, possibly due to differences in time of administration [ 151 , 159 , 160 , 161 ]. Inflammatory factors IL-6 and TNF-α secreted by microglia after injury have been shown to decrease the survival of Doublecortin-positive (Dcx+) cells in vitro [ 159 ].…”

Section: Effect Of Msc Derived Extracellular Vesicles On Neuro-vascular Unit After Strokementioning

confidence: 99%

Mesenchymal Stem Cell Derived Extracellular Vesicles for Repairing the Neurovascular Unit after Ischemic Stroke

Davis

Savitz

Satani

2021

Cells

View full text Add to dashboard Cite

Ischemic stroke is a debilitating disease and one of the leading causes of long-term disability. During the early phase after ischemic stroke, the blood-brain barrier (BBB) exhibits increased permeability and disruption, leading to an influx of immune cells and inflammatory molecules that exacerbate the damage to the brain tissue. Mesenchymal stem cells have been investigated as a promising therapy to improve the recovery after ischemic stroke. The therapeutic effects imparted by MSCs are mostly paracrine. Recently, the role of extracellular vesicles released by these MSCs have been studied as possible carriers of information to the brain. This review focuses on the potential of MSC derived EVs to repair the components of the neurovascular unit (NVU) controlling the BBB, in order to promote overall recovery from stroke. Here, we review the techniques for increasing the effectiveness of MSC-based therapeutics, such as improved homing capabilities, bioengineering protein expression, modified culture conditions, and customizing the contents of EVs. Combining multiple techniques targeting NVU repair may provide the basis for improved future stroke treatment paradigms.

show abstract

“…However, the parallel investigation of EVs secreted by MSCs of different origin emphasized the heterogeneity of their effects. For example, EV regulation can make prominent both the innate and adaptive immune reactions; the EVinduced altered effects can appear in several immune cells, not only various lymphocytes but also natural killer cells, dendritic cells and especially macrophages; MSC-EVs can govern immune-modulatory effectors or transmit active signal molecules, thus participating in various distinct processes such as differentiation, activation, proliferation and also suppression of immune cells [11][12][13][14]. Moreover, MSC-EVs from different tissues (bone marrow, adipose tissue, and umbilical cord) exhibit different cargo proteins [15].…”

Section: Innovative Role 0f Msc-evmentioning

confidence: 99%

News About the Extracellular Vesicles from Mesenchymal Stem Cells: Functions, Therapy and Protection from COVID-19

Meldolesi

2021

Journal of Experimental Pathology

View full text Add to dashboard Cite

This is a Commentary of a review about extracellular vesicles of immune cells published two years ago in Clinical and Experimental Immunology, a prestigious journal of the field. The aim is to establish whether, and to what extent, results in scientific area of the review have been extended and strengthened by innovative findings of considerable interest. The analysis of the recently published results has revealed that in various areas of the review developments have occurred. However, innovative findings have been only about the extracellular vesicles secreted by mesenchymal stem cells, usually indicated as MSC-EVs. Based on these findings, the Commentary has been focused on recent MSC-EVs findings presented in three Sections dealing with 1. recently appeared, relevant functions of the latter vesicles; 2. therapeutic processes developed according well known criteria, however innovative in many respects; and 3. protection of COVID-19 disease patients from organ lesions induced by the specific virus, SARS-CoV-2, during the disease. As everybody knows, the COVID-19 pandemic started at the end of 2019, thus after the publication of the aforementioned review. Data of Section 3 are therefore innovative, of great potential interest also at the clinical level, applied by translational medicine to various organs, from lung to brain, heart, kidney, immune and other cells. In view of its relevance, the author expects that research and medical use of MSC-EV, active at present, will be further developed, acquiring additional relevance in the near future.

show abstract

Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization

Cited by 82 publications

References 113 publications

The Crosstalk between Mesenchymal Stem Cells and Macrophages in Bone Regeneration: A Systematic Review

The Crosstalk between Mesenchymal Stem Cells and Macrophages in Bone Regeneration: A Systematic Review

Mesenchymal Stem Cell Derived Extracellular Vesicles for Repairing the Neurovascular Unit after Ischemic Stroke

News About the Extracellular Vesicles from Mesenchymal Stem Cells: Functions, Therapy and Protection from COVID-19

Contact Info

Product

Resources

About