Mesenchymal Stem Cell Differentiation Properties and Available Microenvironment

Gugjoo, Mudasir Bashir; Pal, Aruna

doi:10.1007/978-981-15-6037-8_5

Cited by 4 publications

(1 citation statement)

References 118 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the widely accepted definition of 'tissue engineering' that was proposed by Robert Nerem in 1988, MSCs can be regarded as an inherent component of the modern regenerative medicine, since they can readily be used for the generation of different cell lineages. The growing success of today's regenerative medicine stems from the pluripotent nature of MSCs that renders them capable of transforming into other cell types with regards to their microenvironment, which consists of non-coding RNAs, among others [303]. A strikingly high proportion of studies have focused on identification of ncRNAs that facilitate or impair the differentiation of MSCs.…”

Section: Signalling Pathways Governing Msc Functionmentioning

confidence: 99%

Unveiling Mesenchymal Stem Cells’ Regenerative Potential in Clinical Applications: Insights in miRNA and lncRNA Implications

Jankowski,

Farzaneh,

Ghaedrahmati

et al. 2023

Cells

View full text Add to dashboard Cite

It is now widely recognized that mesenchymal stem cells (MSCs) possess the capacity to differentiate into a wide array of cell types. Numerous studies have identified the role of lncRNA in the regulation of MSC differentiation. It is important to elucidate the role and interplay of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the regulation of signalling pathways that govern MSC function. Furthermore, miRNAs and lncRNAs are important clinical for innovative strategies aimed at addressing a wide spectrum of existing and emerging disease. Hence it is important to consider their impact on MSC function and differentiation. Examining the data available in public databases, we have collected the literature containing the latest discoveries pertaining to human stem cells and their potential in both fundamental research and clinical applications. Furthermore, we have compiled completed clinical studies that revolve around the application of MSCs, shedding light on the opportunities presented by harnessing the regulatory potential of miRNAs and lncRNAs. This exploration of the therapeutic possibilities offered by miRNAs and lncRNAs within MSCs unveils exciting prospects for the development of precision therapies and personalized treatment approaches. Ultimately, these advancements promise to augment the efficacy of regenerative strategies and produce positive outcomes for patients. As research in this field continues to evolve, it is imperative to explore and exploit the vast potential of miRNAs and lncRNAs as therapeutic agents. The findings provide a solid basis for ongoing investigations, fuelling the quest to fully unlock the regenerative potential of MSCs.

show abstract

Section: Signalling Pathways Governing Msc Functionmentioning

confidence: 99%

Unveiling Mesenchymal Stem Cells’ Regenerative Potential in Clinical Applications: Insights in miRNA and lncRNA Implications

Jankowski,

Farzaneh,

Ghaedrahmati

et al. 2023

Cells

View full text Add to dashboard Cite

show abstract

Mesenchymal Stem Cells Therapeutic Applications in Integumentary System Disorders

Gugjoo

2022

Therapeutic Applications of Mesenchymal Stem Cells in Veterinary Medicine

View full text Add to dashboard Cite

Clinical applications of adipose-derived stromal vascular fraction in veterinary practice

Sharun

Jambagi

Kumar

et al. 2022

Veterinary Quarterly

View full text Add to dashboard Cite

Adipose tissue-derived stromal vascular fraction (AdSVF) comprises a heterogeneous cell population, including the multipotent mesenchymal stem cells, hematopoietic stem cells, immune cells, endothelial cells, fibroblasts, and pericytes. As such, multipotent adipose tissue-derived mesenchymal stem cells (AdMSCs), are one of the important components of AdSVF. Commonly used techniques to harvest AdSVF involve enzymatic or non-enzymatic methods. The enzymatic method is considered to be the gold standard technique due to its higher yield. The cellular components of AdSVF can be resuspended in normal saline, platelet-rich plasma, or phosphate-buffered saline to produce a ready-to-use solution. Freshly isolated AdSVF has exhibited promising osteogenic and vasculogenic capacity. AdSVF has already been proven to possess therapeutic potential for osteoarthritis management. It is also an attractive therapeutic option for enhancing wound healing. In addition, the combined use of AdSVF and platelet-rich plasma has an additive stimulatory effect in accelerating wound healing and can be considered an alternative to AdMSC treatment. It is also widely used for managing various orthopaedic conditions in clinical settings and has the potential for regenerating bone, cartilage, and tendons. Autologous AdSVF cells are used along with bone substitutes and other biological factors as an alternative to conventional bone grafting techniques owing to their promising osteogenic and vasculogenic capacity. It can also be used for treating osteonecrosis, meniscus tear, chondromalacia, and tendon injuries in veterinary practice. It has several advantages over in vitro expanded AdMSC, including precluding the need for culturing, reduced risk of cell contamination, and cost-effectiveness, making it ideal for clinical use.

show abstract

Mesenchymal Stem Cell Differentiation Properties and Available Microenvironment

Cited by 4 publications

References 118 publications

Unveiling Mesenchymal Stem Cells’ Regenerative Potential in Clinical Applications: Insights in miRNA and lncRNA Implications

Unveiling Mesenchymal Stem Cells’ Regenerative Potential in Clinical Applications: Insights in miRNA and lncRNA Implications

Mesenchymal Stem Cells Therapeutic Applications in Integumentary System Disorders

Clinical applications of adipose-derived stromal vascular fraction in veterinary practice

Contact Info

Product

Resources

About