Mesenchymal Stem Cell-injected Omental Patch More Effective Promoting Wound Healing in Bowel Perforation Animal Model

Ekasaputra, Vito Mahendra; Putra, Agung; Muhar, Adi Muradi; Varessa, Jherin; Cikita, Rafeni Bunga; Ns., S.Agung Wijaya, , S.Kep.; Nazar, Mohammad Ariq

doi:10.5455/medarh.2020.74.332-336

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…Moreover, further in vivo results showed that IOSE80 cells displayed robust migration dynamics and self-organization ability. Immunofluorescence revealed that GFP-carrying IOSE80 cells formed a corpus luteum-like structure on day 7 after transplantation, which resembled a “patch” after wound healing [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

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Identification and characterization of multipotential stem cells in immortalized normal ovarian surface epithelial cells

Hou,

Hong,

Cao

et al. 2024

ABBS

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The ovarian surface epithelium (OSE) is a single layer of squamous-to-cuboidal epithelial cells that experience repetitive ovulatory rupture and subsequent repair. However, the characteristics of human immortalized ovarian surface epithelial cells (IOSE80) remain elusive. This study aims to determine whether IOSE80 cells have the characteristics of stem cell proliferation and multilineage differentiation and their application in regenerative medicine. IOSE80 cells are sequenced by high-throughput transcriptome analysis, and 5 sets of public data are used to compare the differences between IOSE80 cells and bone marrow mesenchymal stem cells, pluripotent stem cells, and oocytes in transcriptome profiling. The IOSE80 cells present a cobblestone-like monolayer and express the epithelial cell marker KRT18; the stem cell markers IFITM3, ALDH1A1, and VIM; lowly express stem cell marker LGR5 and germ cell markers DDX4 and DAZL. In addition, the GO terms “regulation of stem cell proliferation”, “epithelial cell proliferation”, etc ., are significantly enriched ( P <0.05). IOSE80 cells have the potential to act as mesenchymal stem cells to differentiate into adipocytes with lipid droplets, osteoblasts, and chondroblasts in vitro . IOSE80 cells express pluripotent stem cell markers, including OCT4, SSEA4, TRA-1-60, and TRA-1-81, and they can be induced into three germ layers in vitro . IOSE80 cells also form oocyte-like cells in vitro and in vivo . In addition, IOSE80 cells exhibit robust proliferation, migration, and ovarian repair functions after in vivo transplantation. This study demonstrates that IOSE80 cells have the characteristics of pluripotent/multipotent stem cells, indicating their important role in tissue engineering and regenerative medicine.

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Section: Discussionmentioning

confidence: 99%

“…The pluripotency of immortalized normal ovarian surface epithelial cells luteum-like structure on day 7 after transplantation, which resembled a "patch" after wound healing [41,42].…”

mentioning

confidence: 99%

Identification and characterization of multipotential stem cells in immortalized normal ovarian surface epithelial cells

Hou,

Hong,

Cao

et al. 2024

ABBS

View full text Add to dashboard Cite

show abstract

“…Mesenchymal Stem Cells (MSCs) have the capability to differentiate into multiple cells lineage and release various anti-inflammatory cytokines and growth factors to promote wound healing [ [4] , [5] , [6] , [7] ]. Multiple studies had reported its ability to improve various organ injuries with promising results [ [8] , [9] , [10] , [11] ].…”

Section: Introductionmentioning

confidence: 99%

Locally injected Mesenchymal Stem Cells optimize angiogenesis by regulating VEGF and CD31 expression in duodenal perforation

Setiawan

Purwanto

Wasita

et al. 2022

Annals of Medicine &Amp; Surgery

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Mesenchymal Stem Cell-injected Omental Patch More Effective Promoting Wound Healing in Bowel Perforation Animal Model

Cited by 2 publications

References 28 publications

Identification and characterization of multipotential stem cells in immortalized normal ovarian surface epithelial cells

Identification and characterization of multipotential stem cells in immortalized normal ovarian surface epithelial cells

Locally injected Mesenchymal Stem Cells optimize angiogenesis by regulating VEGF and CD31 expression in duodenal perforation

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