Mesenchymal Stem Cell Therapy for Apoptosis After Spinal Cord Injury

Dasari, Venkata Ramesh; Veeravalli, Krishna Kumar; Rao, Jasti S.; Fassett, Dan; Dinh, Dzung H.

doi:10.5772/29332

Cited by 1 publication

(1 citation statement)

References 227 publications

(243 reference statements)

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“…Mesenchymal stem cells are ideally suited to address many pathophysiological consequences of SCI [3] . The major goals for the therapeutic use of stem cells is regeneration of axons, prevention of apoptosis and replacement of lost cells, particularly oligodendrocytes, in order to facilitate the remyelination of spared axons [31] . In this review, we touch upon the therapeutic applications of MSCs after SCI.…”

Section: Msc Therapy After Scimentioning

confidence: 99%

Mesenchymal stem cells in the treatment of spinal cord injuries: A review

Dasari

Veeravalli

Dinh

2014

WJSC

184

144

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With technological advances in basic research, the intricate mechanism of secondary delayed spinal cord injury (SCI) continues to unravel at a rapid pace. However, despite our deeper understanding of the molecular changes occurring after initial insult to the spinal cord, the cure for paralysis remains elusive. Current treatment of SCI is limited to early administration of high dose steroids to mitigate the harmful effect of cord edema that occurs after SCI and to reduce the cascade of secondary delayed SCI. R ecent evident-based clinical studies have cast doubt on the clinical benefit of steroids in SCI and intense focus on stem cell-based therapy has yielded some encouraging results. An array of mesenchymal stem cells (MSCs) from various sources with novel and promising strategies are being developed to improve function after SCI. In this review, we briefly discuss the pathophysiology of spinal cord injuries and characteristics and the potential sources of MSCs that can be used in the treatment of SCI. We will discuss the progress of MSCs application in research, focusing on the neuroprotective properties of MSCs. Finally, we will discuss the results from preclinical and clinical trials involving stem cell-based therapy in SCI. Core tip: Despite our deeper understanding of the molecular changes that occurs after the spinal cord injury (SCI), the cure for paralysis remains elusive. In this review, the pathophysiology of SCI and characteristics and potential sources of mesenchymal stem cells (MSCs) that can be used in the treatment of SCI were discussed. We also discussed the progress of application of MSCs in research focusing on the neuroprotective properties of MSCs. Finally, we discussed the results from preclinical and clinical trials involving stem cell-based therapy in SCI.

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Section: Msc Therapy After Scimentioning

confidence: 99%