Mesenchymal Stem Cell Therapy in Acute Liver Failure

Wang, Yong-Hong; Chen, En‐Qiang

doi:10.5009/gnl220417

Cited by 12 publications

(2 citation statements)

References 94 publications

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“…Stem-cell therapy has great promise and has been revealed as a therapeutic option for ALF [ 21 , 22 ]. After investigating different types of stem cells, researchers have determined that human umbilical cord-derived mesenchymal stem cells (H-uc MSCs) are an appropriate treatment option, as these cells can be easily obtained and are characterized by their high quality, purity, and abundance.…”

Section: Introductionmentioning

confidence: 99%

Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading

Cheng,

Shi,

et al. 2024

ABBS

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Acute liver failure (ALF) is a significant global issue with elevated morbidity and mortality rates. There is an urgent and pressing need for secure and effective treatments. Ferroptosis, a novel iron-dependent regulation of cell death, plays a significant role in multiple pathological processes associated with liver diseases, including ALF. Several studies have demonstrated that mesenchymal stem cells (MSCs) have promising therapeutic potential in the treatment of ALF. This study aims to investigate the positive effects of MSCs against ferroptosis in an ALF model and explore the underlying molecular mechanisms of their therapeutic function. Our results show that intravenously injected MSCs protect against ferroptosis in ALF mouse models. MSCs decrease iron deposition in the liver of ALF mice by downregulating hepcidin level and upregulating FPN1 level. MSCs labelled with Dil are mainly observed in the hepatic sinusoid and exhibit colocalization with the macrophage marker CD11b fluorescence. ELISA demonstrates a high level of IGF1 in the CCL 4 +MSC group. Suppressing the IGF1 effect by the PPP blocks the therapeutic effect of MSCs against ferroptosis in ALF mice. Furthermore, disruption of IGF1 function results in iron deposition in the liver tissue due to impaired inhibitory effects of MSCs on hepcidin level. Our findings suggest that MSCs alleviate ferroptosis induced by disorders of iron metabolism in ALF mice by elevating IGF1 level. Moreover, MSCs are identified as a promising cell source for ferroptosis treatment in ALF mice.

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Section: Introductionmentioning

confidence: 99%

Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading

Cheng,

Shi,

et al. 2024

ABBS

View full text Add to dashboard Cite

show abstract

“…Stem cells can exert paracrine effects by secreting factors, such as cytokines and inflammatory factors, and immunomodulatory effects by interacting with immune cells. Their low immunogenicity makes them immune to rejection at the time of transplantation ( 3 ). In some cases, inflammatory stimuli cause MSCs to suppress or enhance the ability of the immune response to localize to the site of inflammation, thus exerting an anti-inflammatory effect ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Latest progress in low-intensity pulsed ultrasound for studying exosomes derived from stem/progenitor cells

He,

Wang,

Deng

et al. 2023

Front. Endocrinol.

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Stem cells have self-renewal, replication, and multidirectional differentiation potential, while progenitor cells are undifferentiated, pluripotent or specialized stem cells. Stem/progenitor cells secrete various factors, such as cytokines, exosomes, non-coding RNAs, and proteins, and have a wide range of applications in regenerative medicine. However, therapies based on stem cells and their secreted exosomes present limitations, such as insufficient source materials, mature differentiation, and low transplantation success rates, and methods addressing these problems are urgently required. Ultrasound is gaining increasing attention as an emerging technology. Low-intensity pulsed ultrasound (LIPUS) has mechanical, thermal, and cavitation effects and produces vibrational stimuli that can lead to a series of biochemical changes in organs, tissues, and cells, such as the release of extracellular bodies, cytokines, and other signals. These changes can alter the cellular microenvironment and affect biological behaviors, such as cell differentiation and proliferation. Here, we discuss the effects of LIPUS on the biological functions of stem/progenitor cells, exosomes, and non-coding RNAs, alterations involved in related pathways, various emerging applications, and future perspectives. We review the roles and mechanisms of LIPUS in stem/progenitor cells and exosomes with the aim of providing a deeper understanding of LIPUS and promoting research and development in this field.

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Multiple Dimensions of using Mesenchymal Stem Cells for Treating Liver Diseases: From Bench to Beside

Chen

Zhang

Huang

et al. 2023

Stem Cell Rev and Rep

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Mesenchymal Stem Cell Therapy in Acute Liver Failure

Cited by 12 publications

References 94 publications

Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading

Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading

Latest progress in low-intensity pulsed ultrasound for studying exosomes derived from stem/progenitor cells

Multiple Dimensions of using Mesenchymal Stem Cells for Treating Liver Diseases: From Bench to Beside

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