Mesenchymal Stem Cells and Psoriasis: Systematic Review

Diotallevi, Federico; Vincenzo, Mariangela Di; Martina, Emanuela; Radi, Giulia; Lariccia, Vincenzo; Offidani, Annamaria; Orciani, Monia; Campanati, Anna

doi:10.3390/ijms232315080

Cited by 9 publications

(2 citation statements)

References 63 publications

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“…MSCs have been successfully isolated from various adult and neonatal tissues, including bone marrow, skin, dental, adipose tissue, umbilical cord, Wharton’s jelly, and placenta [ 38 , 41 , 42 , 43 , 44 ]. Dental pulp tissue-derived MSCs, notably, offer distinct advantages over other MSC sources, such as bone marrow, adipose tissue, peripheral blood, and umbilical cord blood, due to their ease of accessibility, good proliferation potential, neurogenic differentiation and neurotrophic capabilities, and negligible ethical issues and minimal invasiveness [ 45 ].…”

Section: The Neurodegenerative Potential Of Dental Stem Cellsmentioning

confidence: 99%

Advancements in Spinal Cord Injury Repair: Insights from Dental-Derived Stem Cells

Wen,

Jiang,

et al. 2024

Biomedicines

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Spinal cord injury (SCI), a prevalent and disabling neurological condition, prompts a growing interest in stem cell therapy as a promising avenue for treatment. Dental-derived stem cells, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHED), stem cells from the apical papilla (SCAP), dental follicle stem cells (DFSCs), are of interest due to their accessibility, minimally invasive extraction, and robust differentiating capabilities. Research indicates their potential to differentiate into neural cells and promote SCI repair in animal models at both tissue and functional levels. This review explores the potential applications of dental-derived stem cells in SCI neural repair, covering stem cell transplantation, conditioned culture medium injection, bioengineered delivery systems, exosomes, extracellular vesicle treatments, and combined therapies. Assessing the clinical effectiveness of dental-derived stem cells in the treatment of SCI, further research is necessary. This includes investigating potential biological mechanisms and conducting Large-animal studies and clinical trials. It is also important to undertake more comprehensive comparisons, optimize the selection of dental-derived stem cell types, and implement a functionalized delivery system. These efforts will enhance the therapeutic potential of dental-derived stem cells for repairing SCI.

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Section: The Neurodegenerative Potential Of Dental Stem Cellsmentioning

confidence: 99%

Advancements in Spinal Cord Injury Repair: Insights from Dental-Derived Stem Cells

Wen,

Jiang,

et al. 2024

Biomedicines

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“…The bone marrow microenvironment plays a critical role in the development and differentiation of hematopoietic cells, and mesenchymal stem cells (MSCs) are considered the central cells in maintaining microenvironmental homeostasis [11,12,13,14]. However, in AA, mesenchymal stem cells exhibit abnormal behavior by preferentially differentiating into adipocytes, which results in bone marrow adipogenesis [15].…”

Section: Introductionmentioning

confidence: 99%

Deciphering the Role of the MST1/2-YAP Axis in Irisin-Treated Aplastic Anemia: Implications for Mesenchymal Stem Cell Function

Liu,

Li,

Guan

et al. 2024

Preprint

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Aplastic anemia (AA) is a debilitating hematological disorder characterized by bone marrow failure. Recent advancements in mesenchymal stem cell (MSC) research have highlighted potential therapeutic avenues, particularly through the modulation of cellular pathways influenced by novel agents like Irisin. This study investigates Irisin's effects on MSCs in the context of AA using advanced techniques such as single-cell sequencing and spatial transcriptomics. Irisin administration in AA model mice significantly altered gene expression in MSCs, particularly affecting 935 genes associated with the Hippo signaling pathway, notably the MST1/2-YAP axis. These changes were linked to decreased adipogenic differentiation and enhanced mitochondrial membrane system homeostasis. In vitro experiments supported these findings, showing Irisin's capability to inhibit the MST1/2-YAP signaling pathway and suppress adipogenesis in bone marrow stem cells (BMSCs). Corresponding in vivo studies demonstrated that Irisin treatment not only downregulated Mst1 and Mst2 but also upregulated Yap expression. Importantly, these molecular alterations led to reduced bone marrow adiposity and improved hematopoietic function in AA mice, showcasing Irisin's potential as an effective treatment option. The study underscores the critical role of the MST1/2-YAP pathway in mediating Irisin's therapeutic effects, suggesting promising strategies for AA management through targeted MSC pathway modulation.

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Mesenchymal stem cell-derived exosomes decrease Hyperplasia in Psoriasis by inducing transforming growth factor β2 (TGF-β2)

Abed,

Arianejad,

Azizi

2024

Mol Biol Rep

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Mesenchymal Stem Cells and Psoriasis: Systematic Review

Cited by 9 publications

References 63 publications

Advancements in Spinal Cord Injury Repair: Insights from Dental-Derived Stem Cells

Advancements in Spinal Cord Injury Repair: Insights from Dental-Derived Stem Cells

Deciphering the Role of the MST1/2-YAP Axis in Irisin-Treated Aplastic Anemia: Implications for Mesenchymal Stem Cell Function

Mesenchymal stem cell-derived exosomes decrease Hyperplasia in Psoriasis by inducing transforming growth factor β2 (TGF-β2)

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