Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

Abstract

Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency and to improve reproductive health for a significant number of women worldwide.

Bone marrow mesenchymal stem cells derived from juvenile macaques reversed ovarian ageing in elderly macaques

“…In our study, a comparative analysis of the HE staining results between the elderly treatment and model groups showed that BMMSCs improved ovarian structure and promoted follicle regeneration. These results are consistent with these reported in previous studies on MSC treatment of ovarian structure destruction and functional decline [28,31,32]. Interestingly, a previous study demonstrated the presence of adult oogonial stem cells (OSCs) in the adult axolotl salamander ovary and showed that ovarian injury induces OSC activation and functional regeneration of the ovaries [33].…”

Therapeutic options for premature ovarian insufficiency: an updated review

“…Mitochondria are transferred from stem cells to adjacent cells through tunnel nanotubes, formed by pro-inflammatory cytokines that drive skeletal rearrangement in stem cells. It has also been recently reported that inflammation-driven transfer of mitochondria from stem cells to oocytes may rescue oocyte quality and embryo development [ 67 , 68 ].…”

Progress in germline stem cell transplantation in mammals and the potential usage

“…For female, the application of MSCs is also an important method that effectively improves ovarian function due to their abilities of differentiation and restoring endometrial function [ 88 ]. Besides, human endometrial MSCs can differentiate into granulosa cells and improve the renewal of GSCs [ 89 ].…”