Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair

Huang, Sha; Lü, Gang; Wu, Yan; Jirigala, Enhe; Xu, Yongan; Ma, Kui; Fu, Xiaobing

doi:10.1016/j.jdermsci.2012.02.002

Cited by 86 publications

(49 citation statements)

References 32 publications

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“…The most promising current technologies, as outlined in several clinical trials cited in this review, include basic fibrin mesh scaffolds in gel form for seeding of MSCs; however, technologies for improving MSC efficiency in wound healing continue to emerge, such as recent studies for microsphere delivery in wound gel. 114 MSC therapy also holds promise in improving wound healing outcomes in other wound care settings, such as surgical wounds or burns. 115,116 Ongoing studies into MSC immunomodulation and wound support in other wound models (myocardial infarction, brain, long bone defects, and others) may continue support advanced wound care research with insights into novel biomaterials and beneficial properties of MSCs in cell therapy.…”

Section: Discussionmentioning

confidence: 99%

Activity of mesenchymal stem cells in therapies for chronic skin wound healing

2013

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Section: Discussionmentioning

confidence: 99%

Activity of mesenchymal stem cells in therapies for chronic skin wound healing

2013

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“…1 There is also evidence of increased wound tensile strength, reduced scarring, and regeneration of epidermal appendages such as sweat glands, sebaceous glands, and hair follicles. 1,11,12 In addition, MSCs also have the potential to restore the structural integrity of the skin by producing extracellular matrix proteins. For example, exogenous MSCs have been shown to provide collagen VII to restore the damaged epidermal-dermal junction in the blistering disorder dystrophic epidermolysis bullosa.…”

Section: Background Bone Marrow-derived Mscs Improve Wound Healingmentioning

confidence: 99%

The Role of Chemokines in Mesenchymal Stem Cell Homing to Wounds

Hocking

2015

Advances in Wound Care

151

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Significance: Mesenchymal stem cells (MSCs) are being administered to cutaneous wounds with the goal of accelerating wound closure and promoting regeneration instead of scar formation. An ongoing challenge for cell-based therapies is achieving effective and optimal targeted delivery and engraftment at the site of injury. Contributing to this challenge is our incomplete understanding of endogenous MSC homing to sites of injury. Recent Advances: Chemokines and their receptors are now recognized as important mediators of stem cell homing. To date, the most studied chemokinechemokine receptor axis in MSC homing to wounds is CXCL12-CXCR4 but recent work suggests that CCL27-CCR10 and CCL21-CCR7 may also be involved. Critical Issues: Strategies to enhance chemokine-mediated MSC homing to wounds are using a variety of approaches to amplify the chemokine signal at the wound site and/or overexpress specific chemokine receptors on the surface of the MSC. Future Directions: Harnessing chemokine signaling may enhance the therapeutic effects of stem cell therapy by increasing the number of both exogenous and endogenous stem cells recruited to the site of injury. Alternatively, chemokine-based therapies directly targeting endogenous stem cells may circumvent the need for the time-consuming and costly isolation and expansion of autologous stem cells prior to therapeutic administration. SCOPE AND SIGNIFICANCEMesenchymal stem cells (MSCs) are being administered to cutaneous wounds with the goal of accelerating wound closure and promoting regeneration instead of scar formation.1 An ongoing challenge for cell-based therapies is achieving effective and optimal targeted delivery and engraftment at the site of injury. Contributing to this challenge is our incomplete understanding of endogenous MSC homing to sites of injury.2 This review will summarize our current knowledge about the role of chemokines in MSC recruitment to wounds. TRANSLATIONAL RELEVANCEThe translational relevance for research defining the chemokines responsible for stem cell homing is significant with a direct impact on stem cell therapy. Harnessing chemokine signaling may enhance the therapeutic effects of stem cell therapy by increasing the number of both exogenous and endogenous stem cells recruited to the site of injury. Alternatively, chemokine-based therapies directly targeting endogenous stem cells may circumvent the need for the time-consuming and costly isolation and expansion of autologous stem cells prior to therapeutic administration. CLINICAL RELEVANCEOngoing clinical trials are investigating the safety and efficacy of MSC therapy for the treatment of

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“…MSC delivery on fi brin microbeads improved wound tensile strength in a radiation-induced impaired wound healing model [ 145 ]. Microsphere cell carriers have also been used to facilitate large-scale clonal expansion of MSCs in bioreactors under xeno-free conditions [ 146 ] and improve stem cell function in skin substitutes [ 147 ].…”

Section: Micro-and Nanofabrication Technologiesmentioning

confidence: 99%