Mesenchymal Stromal Cell-Like Cells Set the Balance of Stimulatory and Inhibitory Signals in Monocyte-Derived Dendritic Cells

Bacskai, Ildiko; Mázló, Anett; Kis-Tóth, Katalin; Szabó, Attila; Panyi, György; Sarkadi, Balázs; Apáti, Ágota; Rajnavölgyi, Éva

doi:10.1089/scd.2014.0509

Cited by 8 publications

(5 citation statements)

References 61 publications

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“… 28 In addition, MSCs can affect the dendritic cell (DCs) phenotype, cytokine release, differentiation and maturation, and weaken their antigen presentation ability. 29 Activated DCs produce a variety of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-12) and express high levels of co-stimulatory molecules (CD40, CD80, and CD86), thereby promoting the development of inflammation. Previous studies have noted the importance of DC maturation and activation in the progression of inflammation.…”

Section: Mechanism Of Mscs and Msc-exos In The Treatment Of Inflammat...mentioning

confidence: 99%

Targeted Therapy for Inflammatory Diseases with Mesenchymal Stem Cells and Their Derived Exosomes: From Basic to Clinics

Wang¹,

Lei²,

Zhang³

et al. 2022

IJN

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Inflammation is a beneficial and physiological process, but there are a number of inflammatory diseases which have detrimental effects on the body. In addition, the drugs used to treat inflammation have toxic side effects when used over a long period of time. Mesenchymal stem cells (MSCs) are pluripotent stem cells that can be isolated from a variety of tissues and can be differentiate into diverse cell types under appropriate conditions. They also exhibit noteworthy anti-inflammatory properties, providing new options for the treatment of inflammatory diseases. The therapeutic potential of MSCs is currently being investigated for various inflammatory diseases, such as kidney injury, lung injury, osteoarthritis (OA), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). MSCs can perform multiple functions, including immunomodulation, homing, and differentiation, to enable damaged tissues to form a balanced inflammatory and regenerative microenvironment under severe inflammatory conditions. In addition, accumulated evidence indicates that exosomes from extracellular vesicles of MSCs (MSC-Exos) play an extraordinary role, mainly by transferring their components to recipient cells. In this review, we summarize the mechanism and clinical trials of MSCs and MSC-Exos in various inflammatory diseases in detail, with a view to contributing to the treatment of MSCs and MSC-Exos in inflammatory diseases.

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Section: Mechanism Of Mscs and Msc-exos In The Treatment Of Inflammat...mentioning

confidence: 99%

Targeted Therapy for Inflammatory Diseases with Mesenchymal Stem Cells and Their Derived Exosomes: From Basic to Clinics

Wang¹,

Lei²,

Zhang³

et al. 2022

IJN

View full text Add to dashboard Cite

show abstract

“…Recent evidence has suggested that adipose-derived MSCs may also have a more potent immunosuppressive effect in vitro than their bone marrow-derived counterparts IDO, PGE2, M-CSF, IL-6, IL-10, and TGF-b. IDO suppresses T and natural killer (NK) cells; PGE2 suppresses B cells and inhibits their differentiation into antibody-producing plasma cells [161], as well as prevent DC maturation in conjunction with M-CSF, IL-6, IL-10, and TGF-b [156,159,[162][163][164][165].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Exploring cell-based tolerance strategies for hand and face transplantation

Fryer

Grahammer

Khalifian

et al. 2015

Expert Review of Clinical Immunology

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Broader clinical application of reconstructive hand and face transplantation is hindered by the need for lifelong immunosuppression for allograft maintenance. In this review, we summarize various cell-based approaches to tolerance induction currently under investigation in both clinical and pre-clinical models to alleviate the need for chronic immunosuppression. These include strategies to induce mixed hematopoietic chimerism, therapy with T and B regulatory cells, regulatory macrophages, tolerogenic dendritic cells, and mesenchymal stem cells. The vascularized, intragraft bone components inherent to reconstructive transplants serve as a continuous source of donor-derived hematopoietic cells, and make hand and face transplants uniquely well suited for cell-based approaches to tolerance that may ultimately tilt the risk-benefit balance for these life-changing, but not life-saving, procedures.

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“…It is known that the MSC cell line indirectly forces the differentiation of monocytes into CD1a − DC-SIGN + CD163 low CTLA-4 + semi-matured moDCs, whereas these cells directly promote the differentiation of CD1a − DC-SIGN low CD163 high M2 macrophage-like cells in a steady state [ 23 ]. Additionally, it is widely accepted that MSCs generally silence the inflammatory features of moDCs upon viral or bacterial infection [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Cell-Free Supernatant Derived from a Lactobacillus casei BL23 Culture Modifies the Antiviral and Immunomodulatory Capacity of Mesenchymal Stromal Cells

Muzsai,

Maryanovsky,

Ander

et al. 2023

Biomedicines

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Immune responses are highly complex and intricately regulated processes involving immune and non-immune cells in close direct and indirect contact with each other. These cells are highly sensitive to environmental signals, including factors derived from microbiota. Here, we demonstrate that the human microbiota member Lactobacillus casei (L. casei)-derived cell-free supernatant (CFS) enhances the sensitivity of mesenchymal-stromal-cell-like (MSCI) cells to viral stimuli and induces the development of dendritic cells (DCs) with anti-inflammatory and antiviral properties via pretreated MSCl cells. Our results showed that the production of INFβ and CXCL10 by MSCl cells upon viral stimulation was dependent on the presence of L. casei-derived extracellular vesicles in CFS during pretreatment. Moreover, L. casei CFS and/or poly (I:C)-conditioned MSCI cells altered the differentiation process of freshly isolated monocytes, as well as the developing DCs’ phenotype and functional activities, such as cytokine and chemokine secretion. Taken together, L. casei CFS contains factors which contribute to the pronounced antiviral response of MSCI cells, avoiding the development of inflammation via the induction of differentiation of anti-inflammatory DCs that retain their antiviral properties.

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Mesenchymal Stromal Cell-Like Cells Set the Balance of Stimulatory and Inhibitory Signals in Monocyte-Derived Dendritic Cells

Cited by 8 publications

References 61 publications

Targeted Therapy for Inflammatory Diseases with Mesenchymal Stem Cells and Their Derived Exosomes: From Basic to Clinics

Targeted Therapy for Inflammatory Diseases with Mesenchymal Stem Cells and Their Derived Exosomes: From Basic to Clinics

Exploring cell-based tolerance strategies for hand and face transplantation

Cell-Free Supernatant Derived from a Lactobacillus casei BL23 Culture Modifies the Antiviral and Immunomodulatory Capacity of Mesenchymal Stromal Cells

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