Mesenchymal stromal cells for the treatment of autoimmune diseases

New ex vivo model of corneal endothelial phacoemulsification injury and rescue therapy with mesenchymal stromal cell secretome

“…Tumor necrosis factor-α stimulated gene/protein is among these secreted factors. 33,34 It is released by mesenchymal stromal cells in response to inflammation and has the beneficial effects of mesenchymal stromal cells in the treatment of heart, 35 cornea, 36 brain, 37 and lung diseases. 38 Specifically, it has been shown that TSG-6 protects corneal endothelial cells from transcorneal cryoinjury through suppression of inflammation.…”

“…Stanniocalcin-1 (STC-1) is another important factor secreted by mesenchymal stromal cells. 33,34 It has also been shown to protect cells from oxidative damage and is a well-known antiapoptotic agent. 40,41 Stanniocalcin-1 is known to be released by mesenchymal stromal cells in response to apoptotic cells' signals.…”