Mesenteric lymph duct ligation after hemorrhagic shock enhances the ATP level and ATPase activity in rat kidneys

Zhang, Limin; Jiang, Lu; Zhao, Zi‐Gang; Niu, Chun‐Yu

doi:10.3109/0886022x.2014.882183

Cited by 9 publications

(5 citation statements)

References 23 publications

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“…GIRI caused damage to distant organs, but both of these interventions need to block the GLS. [19,30] The GLS, as a supplement to the SRC system, plays an important role in maintaining body uid balance and nutrient metabolism. However, GLD and GLL are "anti-physiological" treatment methods, which are di cult to apply in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the gut is thought to be the origin of in ammation and the mediator of MODS. [15][16][17][18][19] However, both GLD and GLL, as "anti-physiological" therapies are unfavorable for application in clinical practice. [20,21] Therefore, we theoretically constructed a therapeutic measure-GL puri cation (GLP) system to block the key link between DAMPs and MPS.…”

Section: Introductionmentioning

confidence: 99%

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Gut Lymph Purification in Rats With Acute Lung Injury Caused By Gut Ischemia Reperfusion Injury

Jin

Zhang

et al. 2021

Preprint

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Rationale: It is unclear whether removing the danger-associated molecular patterns (DAMPs) of gut lymph (GL) in the rats of gut ischemia-reperfusion injury (GIRI) model may reduce the distant organ lung injury.Objective: To determine whether oXiris gut lymph purification (GLP) may remove the DAMPs of GL in the rats’ model of acute lung injury (ALI) caused by GIRI.Methods: The experimental rats were divided into four groups: Sham group, GIRI group, GIRI + gut lymph drainage (GLD) group, and GIRI + GLP group. After successful modeling, the lung tissue samples of rats in each group were taken for hematoxylin-eosin (HE) staining and detection of expression levels of apoptotic indexes. The level of DAMPs was detected in blood and lymph. We observed its microstructure of type II alveolar epithelial cells (AECⅡ), and detected the expression level of apoptosis indexes.Measurements and Main Results: GIRI-induced destruction of alveolar structure, thickened alveolar walls, inflammatory cell infiltration emerged in the GIRI group, HMGB-1 and IL-6 levels significantly increased, and HSP70 and IL-10 levels reduced in lymph and serum. Compared with GIRI group, the lung tissue damage in GIRI + GLP group significantly improved, the expression level of HMGB-1 and IL-6 in the lymph and serum reduced, and HSP70 and IL-10 increased. The organelle structure of AECII in GIRI + GLP group was significantly improved compared with the GIRI group. Conclusions: oXiris GLP blocks the key link between DAMPs and mononuclear phagocyte system to inhibit inflammation and cell apoptosis, thereby reducing ALI induced by GIRI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gut Lymph Purification in Rats With Acute Lung Injury Caused By Gut Ischemia Reperfusion Injury

Jin

Zhang

et al. 2021

Preprint

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“…[5][6][7][8][9][10] Sufficiently draining the GLF or ligating the gut lymph vessels (GLVs or thoracic ducts) significantly reduced the risk of generator organ injury in rats. [11][12][13][14][15] These studies suggest that the GLF plays a pivotal role in MODS pathogenesis. Therefore, the gut is thought to be the origin of inflammation and the mediator of MODS.…”

Section: Introductionmentioning

confidence: 94%

Gut lymph purification regulates monocyte activity in rats with ischemia-reperfusion injury-induced sepsis

Zhang

Chen

Jin

et al. 2020

Preprint

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ObjectiveTo confirm that gut lymph purification (GLP) based on oXiris regulates monocyte activity by targeting the removal of ischemia-reperfusion injury (IRI)-induced intestinal toxic substances (ITSs) in rats. MethodsSepsis was induced by intestinal IRI in 24 adult male Sprague-Dawley rats that were randomly divided into the control, intestinal IRI, and IRI+GLP groups. The gut lymph fluid (GLF) was drained for 180 minutes.The ITSs levels and the proliferation, apoptosis and positive expression rates of MHC-II molecules of monocytes coincubated with the GLF were detected. ResultsEndotoxin, TNF-α, IL-4, IL-6 and IL-10 levels in the lymph and plasma of the IRI group were significantly higher than those of the control group (p < 0.01). Compared with the IRI group, GLP treatment significantly decreased the ITS levels (p < 0.05). Monocyte proliferation and the positive expression rate of MHCmolecules were significantly reduced after co-culturing with GLF upon IRI (p < 0.01), and the apoptotic rate was significantly increased (p < 0.01). However, culturing monocytes with GLP significantly enhanced the monocyte proliferation, increased the positive expression rate of MHC-monocytes (p < 0.01), and reduced the apoptotic rate (p < 0.01). ConclusionsGLP therapy based on oXiris effectively removed ITSs from the GLF after IRI, thereby blocking the main process of multiple organ dysfunction syndrome by regulating monocyte activity.

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“…The activation of GPER1 also protected the kidney from IRI through enhancing glomerular endothelial barrier function and regulating the content of NO in renal interlobular artery smooth muscle and endothelial cells [131,132]. Renal Na þ /K þ -ATPase is a well-recognized energy-dependent sodium pump which helps maintain the electrolyte and fluid balance via manipulating the transport of certain solutes [133,134]. Under the circumstance of renal IRI, the impaired activity of Na þ /K þ -ATPase contributed to abnormal hydroelectrolyte status [135,136].…”

Section: Estrogen and Ers In Aki Settingsmentioning

confidence: 99%

Estrogen and estrogen receptors in kidney diseases

Chen

2021

Renal Failure

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Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to global health within this century. Studies have suggested that estrogen and estrogen receptors (ERs) play important roles in many physiological processes in the kidney. For instance, they are crucial in maintaining mitochondrial homeostasis and modulating endothelin-1 (ET-1) system in the kidney. Estrogen takes part in the kidney repair and regeneration via its receptors. Estrogen also participates in the regulation of phosphorus homeostasis via its receptors in the proximal tubule. The ERa polymorphisms have been associated with the susceptibilities and outcomes of several renal diseases. As a consequence, the altered or dysregulated estrogen/ERs signaling pathways may contribute to a variety of kidney diseases, including various causes-induced AKI, diabetic kidney disease (DKD), lupus nephritis (LN), IgA nephropathy (IgAN), CKD complications, etc. Experimental and clinical studies have shown that targeting estrogen/ERs signaling pathways might have protective effects against certain renal disorders. However, many unsolved problems still exist in knowledge regarding the roles of estrogen and ERs in distinct kidney diseases. Further research is needed to shed light on this area and to enable the discovery of pathwayspecific therapies for kidney diseases.

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Mesenteric lymph duct ligation after hemorrhagic shock enhances the ATP level and ATPase activity in rat kidneys

Cited by 9 publications

References 23 publications

Gut Lymph Purification in Rats With Acute Lung Injury Caused By Gut Ischemia Reperfusion Injury

Gut Lymph Purification in Rats With Acute Lung Injury Caused By Gut Ischemia Reperfusion Injury

Gut lymph purification regulates monocyte activity in rats with ischemia-reperfusion injury-induced sepsis

Estrogen and estrogen receptors in kidney diseases

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