Mesenteric venous thrombosis

Harward, Timothy R.S.; Green, David; Bergan, John J.; Rizzo, Robert J.; Yao, James S.T.

doi:10.1016/0741-5214(89)90053-0

Cited by 153 publications

(95 citation statements)

References 22 publications

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, acute MVTis a life-threatening condition if left untreated (1)(2)(3)(4). Although diagnosis of MVTis sometimes difficult because of nonspecific abdominal symptoms, early diagnosis and the immediate use of anticoagulation are the mainstay of therapy (2)(3)(4)(5)(6). Recently, as a result of the increased awareness of disorders predisposing to MVT,some cases of MVTwere explained as some hypercoagulable disorders, such as deficiency of antithrombin III, protein S, or protein C (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

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Mesenteric Venous Thrombosis in Hereditary Protein C Deficiency with the Mutation at Arg169 (CGG.RAR.TGG).

et al. 2003

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A 39-year-old man with no significant medical history was admitted to our hospital with severe abdominal pain and melena. Computed tomographic (CT) scans demonstrated superior mesenteric venous thrombosis. Although thrombolysis and anticoagulant therapy was started immediately, symptoms of strangulation ileus developed.Laparotomy was therefore performed and revealed necrotic stenosis of the ileum. The patient, his father and sisters showed low protein C levels. Direct sequencing analysis of their protein C gene revealed a heterozygous mutation at codon 169 corresponding to the cleavage site of the activation peptide, which was referred to as protein C Tochigi. (Internal Medicine 42: 110-116, 2003)

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mesenteric Venous Thrombosis in Hereditary Protein C Deficiency with the Mutation at Arg169 (CGG.RAR.TGG).

et al. 2003

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“…The most important finding is pain disproportionate to physical examination findings. Depending on the type of mesenteric ischemia, patients may present with a variety of signs and symptoms (Zakhour et al 1987;Harward et al 1989;Grieshop et al 1991;Gennaro et al 1993;Lobo Martíez et al 1993;Rhee et al1994;Brandt et al 2000;Ağaoğlu et al 2005;Huang et al 2005). Acute arterial mesenteric ischemia typically has the most abrupt and painful presentation of all types.…”

Section: Presentation and Clinical Featuresmentioning

confidence: 99%

“…Other predisposingconditions include hypotension from cardiac heart failure, myocardial infarction, sepsis, aortic insufficiency, severe liver or renal disease, or recent major cardiac or abdominal surgery and the use of digitalis (Endress et al 1992;Bassiouny 1997;Sudhakar et al 1997;Cappell 1998;Liu et al 2000;Schoots et al 2004). Mesenteric venous thrombosis occurs in patients, who are found to have the following pre-disposing conditions: hypercoagulability (protein C and S or antithrombin III deficiency,) hematologic conditions (polycythemia vera) pregnancy, oral contraceptive use, malignancy, infections, portal hypertension, venous trauma (Zakhour et al 1987;Harward et al 1989;Grieshop et al 1991;Gennaro et al 1993;Cappell 1998;Liu et al 2000;Ağaoğlu et al 2005). The consequences of vascular occlusion depend on the vessels involved and the status of collateral channels (Brandt et al 2000).…”

Section: Pathogenesismentioning

confidence: 99%

Mesenteric Ischemia: Still a Deadly Puzzle for the Medical Community

Stamatakos

Stefanaki

Mastrokalos

et al. 2008

Tohoku J. Exp. Med.

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The main goal of this article is to update etiology, epidemiology, diagnosis, treatment and outcome of the various causes of mesenteric ischemia in order to elucidate its labyrinthine clinical riddle, by reviewing the current English medical literature. Mesenteric ischemia is a quite uncommon disorder, observed in the emergency department. It is a lifethreatening vascular emergency that requires early diagnosis and intervention to restore mesenteric blood flow and to prevent bowel necrosis and patient death. Consequently, it is a vital diagnosis to make because of its high mortality rate and its thorny complications. The underlying causes vary, and the prognosis depends on the specific findings during clinical examination. Vague and nonspecific clinical findings and limitations of diagnostic studies make the diagnosis a significant challenge. The prognosis of acute mesenteric ischemia of any type is grave. The complications following this medical jigsaw puzzle are also severe. Patients in whom the diagnosis is missed until infarction occurs have a mortality rate of 90%. Even with good treatment, up to 50-80% of patients die. Survivors of extensive bowel resection face lifelong disability. Despite the progress in understanding the pathogenesis of mesenteric ischemia and the development of treatment modalities, the entity remains a diagnostic challenge for clinicians. Delay in diagnosis contributes to a high mortality rate. Early diagnosis and adequate treatment can improve the clinical outcome. Even if diagnostic modalities have improved since the first successful attempts to confront effectively this clinical entity, mesenteric ischemia still remains a lethal diagnostic enigma for the medical community.Mesenteric Ischemia; thrombosis; bowel infarction; atherosclerosis; mesenteric venous thrombosis; mesenteric thromboendarterectomy.Tohoku

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“…Previously, the diagnosis was made only at laparotomy or autopsy, but now imaging techniques allow it to be recognised during life [1]. Aetiology of this condition is usually a hypercoagulable state [2,3]. So far this complication has never been described due to stay at high or extreme altitude.…”

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confidence: 99%

Pain Abdomen at Extreme Altitudes: Sinister Implications

Anand

Saha²,

Sharma³

et al. 2001

Medical Journal Armed Forces India

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2 cases of portal, splenic and superior mesenteric vein thromboses related to prolonged stay at high altitude are presented. Both presented initiaUy with innocuous appearing vague pain in abdomen with no physical signs. Later hepatosplenomegaly, and pleural effusion (left) was also detected. Diagnosis was based on CT scan and colour Doppler study showing thrombosed veins and porto-systemic coUateral. 1 patient developed a large splenic haernatoma requiring splenectomy. Both were managed with early anticoagulation and have done well in the short follow up. MJAFI 2001; 57: 158-160

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Mesenteric venous thrombosis

Cited by 153 publications

References 22 publications

Mesenteric Venous Thrombosis in Hereditary Protein C Deficiency with the Mutation at Arg169 (CGG.RAR.TGG).

Mesenteric Venous Thrombosis in Hereditary Protein C Deficiency with the Mutation at Arg169 (CGG.RAR.TGG).

Mesenteric Ischemia: Still a Deadly Puzzle for the Medical Community

Pain Abdomen at Extreme Altitudes: Sinister Implications

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